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Biomedical subjects

J A Page

Publications and source records attributed to J A Page.

16 recordsLinked to original sources
PubMed1991

'Gobsmacking grins'.

Over the past decade, marked reductions have been recorded in dental caries levels for teenage children in Somerset. These have been documented in BASCD Regional Surveys and reflect a national picture of improving dental health. Nevertheless, over the same period of time, the level of gingival health for Somerset teenagers has remained relatively static.

Adolescent↗
PubMed1991

Evaluation of a mass media community smoking cessation campaign.

The effectiveness of a smoking cessation campaign that included both printed and televised materials was evaluated in registrant and randomly acquired samples of smokers during the first month postcampaign and again at 3 months. Registrant and random samples differed on several sociodemographic variables. Registrants had much higher rates of abstinence at both times compared to the randomly acquired group. Nicotine gum replacement was used more frequently among the registrant group. Fifteen percent of registrants who had not attempted to quit at Time 1 were abstinent 3 months postcampaign. Registering to participate in print and televised cessation programs may be related to a change in smoking behavior.

Adolescent↗
PubMed1983

Gas-liquid chromatographic determination of salsolinol in the striatum of rat brain during the calcium carbimide--ethanol interaction.

An assay has been developed for the measurement of salsolinol in brain tissue that involves tissue homogenization in dilute hydrochloric acid, purification of the supernatant by cation-exchange chromatography, derivatization of the eluate with heptafluorobutyric anhydride, and analysis by gas-liquid chromatography with electron capture detection using p-tyramine as the internal standard. The lower limit of quantitative sensitivity, using aqueous standards, is 2.5 ng salsolinol per brain sample. This assay was used to study salsolinol formation in rat brain during the calcium carbimide-ethanol interaction. Rats were administered ethanol (1.0 g/kg) by oral intubation 3 h after intraperitoneal administration of calcium carbimide (7.0 mg/kg). Salsolinol was measured in the striatum over a 270-min period after ethanol administration. Salsolinol concentration appeared to be maximal (275 ng/g) at 90 min and then declined with an apparent elimination half-life of 39.8 min.

Animals↗
PubMedDate not supplied

Doxorubicin-associated flare reactions.

An analysis was made of 539 cases of venous flare reactions associated with the administration of doxorubicin. These reactions always were nondebilitating and generally were transient with complete resolution occurring within 45 minutes of onset in 462 patients (86%). Local urticaria occurred in 133 patients (25%), and 35 patients (6%) reported either vein pain or a stinging sensation. In 20 cases (4%), erythema in the region immediately surrounding the infusion site accompanied the primary manifestation of erythema along the course of the vein proximal to the infusion site. The incidence of initial flare reactions peaked in the autumn months. These reactions frequently occurred at clinical sites in sporadic clusters. Clinical features are described that differentiate flare reactions from early extravasations of doxorubicin. Procedures for minimizing the possibility of the occurrence or reappearance of flare reactions are suggested.

Adolescent↗