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Biomedical subjects

J A Olsen

Publications and source records attributed to J A Olsen.

41 records · Page 3Linked to original sources
PubMedDate not supplied

Aiding priority setting in health care: is there a role for the contingent valuation method?

The paper discusses some methodological and measurement aspects with the contingent valuation (CV) method which appear to create problems when eliciting preferences for the relative social valuation of alternative health care programmes. After pointing to biases which tend to exaggerate the true valuations, emphasis is placed on framing issues when applied to health care. Thereafter the paper discusses the extent to which preferences elicited through one's willingness to pay can be used to infer how the respondent would prioritize between the health care programmes in question. New empirical evidence is presented which suggest discrepancies between a CV ranking and the ranking expressed when making a direct ordinal comparison.

Bias↗
PubMedDate not supplied

Persons vs years: two ways of eliciting implicit weights.

The paper presents two methods for eliciting individuals' implicit weights to be attached to health benefits which extend over time. The first is a person-trade-off type which implies that social weights are attached to years with improved health when these are distributed between different groups of people. The second method is based on time-trade-off which yields private weights to succeeding years with improved health for oneself. Emphasis is placed on methodological issues, but some preliminary results obtained from small samples are also presented.

Humans↗
PubMedDate not supplied

Combinatorial solid-phase synthesis of hapalosin mimetics.

The solid-phase synthesis of a small library of mimetics of the cyclic depsipeptide hapalosin is described. 3-Amino-4-hydroxy-5-nitrobenzoic acid was anchored through the anilino moiety to a backbone amide linker (BAL) handle support. Using chemoselective reactions and without the need for protecting group manipulations, the benzoic acid group was first amidated, then the aniline nitrogen was acylated, and finally the nitro group was reduced to an amine and acylated or reductively alkylated, to generate a 12-member library.

Alkylation↗