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Biomedical subjects

J A Morgan

Publications and source records attributed to J A Morgan.

97 records · Page 6Linked to original sources
PubMedDate not supplied

Parallel synthesis and biocatalytic amplification of a cross-conjugated cyclopentenone library.

A combination of parallel chemical synthesis and biocatalysis has been used to prepare and amplify a library of cross-conjugated cyclopentenones. A number of marine and terrestrial natural products with antibiotic activity are known to incorporate this pharmacophore. The library was screened for anticancer, antimycobacterial, antifungal, and antibacterial activity. The positive results from the screens provide an indication of the structural features that are associated with activity in the various assays and suggest promising avenues for further inquiry.

Biotransformation↗
PubMedDate not supplied

Functional CT imaging of the acute hyperemic response to radiation therapy of the prostate gland: early experience.

PURPOSE: Functional CT can measure perfusion and permeability. We hypothesized that acute changes could be measured in these indexes following radiation therapy (RT) to the prostate gland. METHOD: Twenty-two patients with prostatic cancer were studied before and 1-2 and 6-12 weeks after RT. A single section through the prostate was repeatedly scanned after contrast medium bolus injection. Contrast agent clearance per unit volume (alpha/V) and fractional vascular volume (fvv) were calculated using Patlak graphical analysis. Perfusion was calculated as the ratio between maximal rate of tissue enhancement and peak arterial enhancement. RESULTS: Significant increases in all indexes occurred after RT. Mean perfusion rose from 0.122 to 0.263 ml/min/ml at 1-2 weeks, mean alpha/V increased from 0.0012 to 0.0016 ml/min/ml at 1-2 weeks, and mean fvv increased from 13.7 to 21% at 1-2 weeks. All three indexes remained elevated at 6-12 weeks after the start of RT. CONCLUSION: Functional CT demonstrated an acute hyperemic response following RT to the prostate gland.

Acute Disease↗
PubMedDate not supplied

Creative discharge planning using the electronic medical record.

A multidisciplinary continuous quality improvement (CQI) team at the authors' facility was commissioned and empowered to study and improve communication among the disciplines involved in discharge planning. CQI methods and tools were applied to analyze the process and determine the improvement. The authors of this article describe the use of a customized electronic medical record system to deliver accurate, rapid technology (DART) at their facility. DART was programmed to improve communication among the disciplines by assisting with the referral process. In addition, users are systematically prompted throughout the discharge process to ensure that all aspects are considered and documented.

Aftercare↗