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Biomedical subjects

J A Moore

Publications and source records attributed to J A Moore.

At least 127 records · Page 7Linked to original sources
PubMed1987

Problems facing the decision-maker in the risk assessment process.

This paper presents an overview of the U.S. Environmental Protection Agency's risk assessment process, describes problems that the Agency faces in conducting risk assessment, in general, and identifies some specific problems that the Agency confronts when conducting risk assessments on suspected developmental toxicants. As noted by the NAS (National Research Council: "Risk Assessment in the Federal Government: Managing the Process." Washington, DC: National Academy Press, 1983, pp 17-83), improving the quality and comprehensiveness of knowledge is the most effective way to improve risk assessment, but some limitations are inherent and may remain unresolvable. Therefore, inferences will always be required. The Agency's challenge is to ensure that these inferences are as soundly based as possible.

Dose-Response Relationship, Drug↗
PubMed1987

The effect on healing of the application of citric acid during replaced flap surgery.

The aim of this double-blind controlled clinical trial was to assess the effect on healing following conditioning the root surface with citric acid during replaced flap surgery. Healing was assessed in 18 pairs of sites in 12 patients before surgery and after 3 months; healing was also assessed in 13 pairs of these sites in 10 of the patients after 9 months. During surgery, the root surface at 1 site from each pair was treated with citric acid pH 0.6 for 3 min and the contralateral site was exposed to sterile saline. Healing was assessed by measuring attachment levels, probing depths and recession; in addition, gingival crevicular fluid flow was measured, as was the degree of bleeding on probing. The mean gain of attachment (mm) in the acid and control groups were 1.0 and 1.2, respectively, at 3 months and 1.1 and 0.9 respectively, at 9 months. The results of this study indicate, both clinically and statistically, that the difference in healing between the acid and the non-acid sites is not significant. Thus no additional benefit is shown by using citric acid in conjunction with replaced flap surgery on anterior teeth.

Adult↗
PubMed1987

The properties of recombinant chicken growth hormone and its effects on growth, body composition, feed efficiency, and other factors in broiler chickens.

Recombinant chicken GH (rcGH) was produced and characterized. Comparison of protein sequence, amino acid composition, mol wt, purity, and immunocross-reactivity showed that except for the N-terminal methionyl group arising from the bacterial expression system, the recombinant and pituitary-derived cGHs were identical. When tested in a hypophysectomized rat growth assay, the recombinant and pituitary materials had the same specific bioactivity. Within 60 min after sc injection of rcGH (480-960 micrograms/kg) in chickens, plasma GH levels increased 4- to 6-fold and remained significantly elevated for at least 5 h. Thrice-daily injections from age 2-24 days had little effect on growth or feed consumption in either male or female broiler chicks. Plasma levels of insulin and triglycerides were significantly elevated by rcGH in 24-day-old females, but not in males. Injection of rcGH counteracted a reduction of tibia length observed in saline-injected controls. The rcGH had no effect on carcass protein, ash content, or nitrogen retention. It is important to note that exogenous GH can be a productivity-enhancing factor in other commercially important species. Administration of bovine GH to cows has been shown to induce a significant increase in milk production (28). This study shows that administration of rcGH to chickens can lead to some significant metabolic effects. However, it is the conclusion of this report that the level of circulating GH is not the limiting factor in the growth of this highly selected species.

Amino Acid Sequence↗
PubMed1987

Recurrent cavitary nodules secondary to Hodgkin's disease.

A patient with nodular sclerosing Hodgkin's disease had at least three episodes of lung involvement consisting of an infiltrate on one occasion and multiple cavitating nodules on the other two. The cytologic and histologic studies of the lung specimens disclosed the presence of Reed-Sternberg cells on each occasion without any evidence for infection. This represents the first time in which recurrent cavitating nodules have been reported with Hodgkin's disease.

Adult↗
PubMed1987

Regional changes in myocyte size and number in propranolol-treated hyperthyroid rats.

The effects of beta-adrenergic blockade and hyperthyroidism on cardiac myocyte structure was examined. Isolated myocytes were prepared from controls and rats treated for 10 weeks with desiccated thyroid hormone (T), propranolol, and desiccated thyroid hormone plus propranolol (TP). Cells were collected from the right and left ventricle. Cell volume was measured with a Coulter Channelyzer system. Cell length was measured directly using a phase microscope. Myocyte cross-sectional area was calculated from cell volume/length. In addition, hearts from animals in each group were perfusion-fixed and myocyte volume percent was determined morphometrically from tissue sections. The number of right and left ventricular myocytes was calculated using data from isolated cells and whole-sectioned tissue. Propranolol normalized heart rate in hyperthyroid rats. Heart weight to body weight ratios were elevated to a similar extent in both T and TP groups. Compared with controls, myocyte volume was increased (p less than 0.01) in each region of T and TP. Right ventricles had a greater degree of myocyte hypertrophy than left ventricles in both rat groups treated with thyroid hormones. Cell length was increased (p less than 0.01) in T and TP. Most of the myocyte hypertrophy, however, was due to an increase in cross-sectional area. Although volume was unchanged with propranolol treatment alone, myocytes from each region had an increase in length (p less than 0.01) and a reduction in cross-sectional area (N.S.). Myocyte number was slightly reduced in each treatment group, but changes were not statistically significant. In conclusion, thyroid hormones stimulate myocyte hypertrophy by increasing both length and cross-sectional area. Propranolol modifies myocyte dimensions in both euthyroid and hyperthyroid rats, but does not prevent thyroid hormone induced cardiac hypertrophy.

Animals↗
PubMed1987

Jarisch-Herxheimer reaction in Lyme disease.

The Jarisch-Herxheimer reaction includes the accentuation of symptoms during antibiotic therapy. More commonly associated with the treatment of syphilis, it can also occur in patients treated for Lyme disease caused by the spirochete Borrelia burgdorferi.

Adult↗
PubMed1986

Regional differences in myocyte size in normal rat heart.

Three independent methods were evaluated in an effort to obtain reliable values for myocyte size in adult Sprague-Dawley rats. Cell volume was determined from isolated myocytes by a Coulter Channelyzer system. Cell volume was also determined from the product of length and cross-sectional area of isolated myocytes. Additionally, myocyte cross-sectional area was measured morphometrically from electron micrographs of whole perfusion-fixed tissue. A major goal was to determine if anatomical methods used to measure cell volume produce values comparable to the more expeditious and objective Coulter Channelyzer method. The results of these experiments showed that myocyte dimensions obtained from all three techniques were similar. The second major objective was to use the above-mentioned techniques to evaluate regional differences in myocyte size. Myocyte cross-sectional area and volume were significantly larger in the endomyocardium than in the epimyocardium of the left ventricle. Right ventricle myocytes had significantly smaller volumes and cross-sectional areas than did left ventricle myocytes. There were no regional differences in cell lengths. We conclude that the Coulter Channelyzer system gives values for isolated myocyte volume that are similar to values obtained with histometric techniques; values for isolated myocyte cross-sectional area were representative of values obtained from myocytes in whole-sectioned tissue; significant regional differences in myocyte size are present in adult rat hearts; and regional variations in myocyte size are due to differences in myocyte cross-sectional area rather than cell length.

Analysis of Variance↗
PubMed1986

Effects of whole cottonseed, cottonseed oil or animal fat on digestibility of wheat straw diets by steers.

Two completely random digestion trials were conducted, each with 12 beef steers (325 kg initial weight), to measure changes in digestibilities of fat and of forage components when fat was added to diets containing 62 to 76% wheat straw. Trial 1 diets contained either no added fat or 6.3% added fat from whole cottonseed (30% of the diet), cottonseed oil or animal fat; diets were formulated to contain equal levels of cottonseed hulls and cottonseed meal. Trial 2 diets contained 0, 2, 4 or 8% added animal fat. In all forms and at all levels, added fat increased apparent digestibility of dietary lipid (P less than .05). However, estimated true digestibility of lipid decreased (from 94 to 71%) as added fat was increased from 0 to 8% (P less than .05). Up to 6.3% added fat increased digestible energy (DE) content of the diet. Fat additions of 2 and 4% increased daily DE intake (P less than .05) and did not depress digestibility of diet components (P greater than .05). Fat additions of 6.3% or greater, either as free fats or as whole cottonseed, reduced (P less than .05) mean acid detergent fiber digestibility from 40 to 28%. In addition to depressing fiber digestibility, 8% added fat reduced (P less than .05) digestibilities of dry matter (from 54 to 47%), organic matter (60 to 52%) and gross energy (60 to 51%). Oil fed as whole cottonseed caused digestibility depressions similar to free fat addition at the same level.(ABSTRACT TRUNCATED AT 250 WORDS)

Animal Feed↗
PubMed1985

Marginal distortion of cast restorations induced by cementation.

Eleven full veneer crowns were directly constructed on brass stylized dies. Crown marginal openings and vertical heights were measured before and after cementation with zinc phosphate cement. The following results were established. The marginal opening of complete veneer gold crowns increased during cementation. The vertical heights of well fitting crowns also increased significantly after cementation.

Crowns↗
PubMed1985

Spiro[4.5] and spiro[4.6] carboxylic acids: cyclic analogues of valproic acid. Synthesis and anticonvulsant evaluation.

Spiro[4.5]decane-2-carboxylic acid (12a), spiro[4.5]decane-2,2-dicarboxylic acid (11a), spiro[4.6]undecane-2-carboxylic acid (12b), spiro[4.6]undecane- 2,2-dicarboxylic acid (11b), and spiro[4.6]undecane-2-acetic acid (13) were synthesized by an improved method and evaluated for anticonvulsant activity. These analogues were synthesized to evaluate the role of the carboxylic acid group as an essential substituent in valproic acid (di-n-propylacetic acid, 1). Carbocyclic spiranes are known to resist metabolic alteration so that any activity elicited by these compounds would be due to the carboxylic acid function and not to any metabolic change. Spiro[4.6]undecane-2-carboxylic acid (12b) was the most active analogue tested and the pentylenetetrazol and picrotoxin evaluations of 12b compared favorably to 1. However, 12b failed to provide adequate protection against maximal electroshock seizures, bicuculline, or strychnine in mice. Possible reasons for these results are discussed.

Animals↗
PubMed1985

Effect of phenobarbital on motor activity and intraventricular hemorrhage in preterm infants with respiratory disease weighing less than 1500 grams.

The use of prophylactic phenobarbital to reduce motor activity and intraventricular hemorrhage was investigated in a controlled exploratory trial with 19 low birthweight premature infants with respiratory disease. Although phenobarbital significantly suppressed movement, it was associated with an increased incidence of intraventricular hemorrhage (IVH). Phenobarbital-treated infants were over eight times more likely to experience IVH than were untreated infants. These data indicate that inhibition of motor activity by phenobarbital may not alleviate the key pathogenetic factors in IVH.

Apgar Score↗
PubMed1985

Becker's melanosis and hypoplasia of the breast and pectoralis major muscle.

Becker's melanosis can be associated with hypoplastic abnormalities. In our patient (the first case report), it occurred in association with an absent pectoralis major muscle. Although more common in males, this patient demonstrates that Becker's melanosis can occur in females and may be congenital.

Adolescent↗
PubMed1985

Simulation: an evolving methodology for health administration education.

Simulation provides a valuable addition to a university's teaching methods. Computer-assisted gaming is especially effective in teaching advanced business strategy and corporate policy when the nature and complexity of the simulation permit. The potential for using simulation techniques in postgraduate professional education and in managerial self-assessment appears to be significant over the next several years.

Education, Graduate↗
PubMed1985

Unilateral keratosis follicularis.

Unilateral keratosis follicularis is considered a localized variant of Darier's disease and should be included in the differential diagnosis of zosteriform keratotic eruptions. The authors present a case report and review the treatment; topical retinoic acid appears to be the treatment of choice.

Adult↗
PubMed1984

Teratogenicity of 2.3.7.8-tetrachlorodibenzofuran (TCDF) in mice.

Treatment of pregnant C57BL/6N mice with 2,3,7,8-tetrachlorodibenzofuran (TCDF) (0, 250, 500, and 1000 micrograms/kg on gestation day 10 or 0, 10, 30, 50, and 100 micrograms/kg on gestation days 10-13) results in dose-related increases in isolated cleft palates and hydronephrotic kidneys in the offspring. TCDF is teratogenic in 100% of the fetuses at dose levels that are not maternally toxic. The fetal kidney is the most sensitive target organ but the kidney lesions may be reversible.

Abnormalities, Drug-Induced↗
PubMed1984

Comparison of tests for the diagnosis of spontaneous encephalitozoonosis in rabbits.

The effectiveness of immunofluorescence, complement fixation, microagglutination serologic tests, intradermal skin test, and detection of histologic lesions were compared for use in diagnosis of spontaneous encephalitozoonosis in rabbits. The India ink and microbead agglutination reactions were compared with immunofluorescence and complement fixation by testing 11 single or pooled sera. Serologic tests correlated best with each other and less well with intradermal tests or presence of lesions. Immunofluorescence, India ink reaction and microbead agglutination were equally useful in detecting antibodies to Encephalitozoon cuniculi. The intradermal test correlated best with the presence of detectable lesions.

Agglutination Tests↗