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Biomedical subjects

J A Moore

Publications and source records attributed to J A Moore.

At least 181 records · Page 10Linked to original sources
PubMed1979

Distribution of egg deposits and gross lesions in nonhuman primates infected with Schistosoma haematobium (Iran).

Widespread tissue egg deposits and gross lesions were recorded in 15 species of primates subsequent to Schistosoma haematobium (Iran) infections of variable intensity and duration. Considerable extra-intestinal involvement as well as pathology in different parts of the urogenital system were observed. Transitional cell carcinoma of the urinary bladder was recorded for Cebus apella.

Animals↗
PubMed1979

A spontaneous outbreak of polycholorinated biphenyl (PCB) toxicity in rhesus monkeys (Macaca mulatta): toxicopathology.

Polychlorinated biphenyls (PCBs) were shown to be the cause of a wasting syndrome and reproductive dysfunction in a group of rhesus monkeys (Macaca mulatta). The polychlorinated biphenyls were found by gas chromatographic analysis in high amounts in the superficial layers of concrete slab floors in the housing facility. The concrete sealant was suspected as the original source although it is not known whether it contained polychlorinated biphenyls before it was applied or if it was contaminated later. Histopathologic findings for the most part were confined to epithelial tissues where squamous metaplasia of several glandular tissues was observed. A striking finding was severe hypertrophy of the glandular stomach and a similar but less severe lesion in the colon. The lesions may be related in part to impaired vitamin A metabolism, but not to a dietary deficiency.

Animals↗
PubMed1979

Haematobium schistosomiasis in the squirrel monkey (Saimiri sciureus).

The squirrel monkey (Saimiri sciureus) accommodates Schistosoma haematobium moderately well. Adults occur in the major viscera but the extent of tissue egg deposits and associated pathology is variable. Pathologic involvement of the urogenital system occurs in a large proportion of hosts exposed to moderate to heavy infections, and bladder pathology is indicative of conditions associated with bladder carcinoma.

Animals↗
PubMed1979

Toxicologic assessments of a commercial polybrominated biphenyl mixture in the rat.

A polybrominated biphenyl fire retardant (Firemaster FF-1) was responsible for the widespread environmental contamination and animal losses in Michigan during 1973 and 1974. In Fischer 344/N rats orally given 30,100,300, and 1,000 mg/kg (5 days/week, 22 total doses) for 4.5 weeks and observed for 90 days after the start of treatment, the LD50 was determined to be 65 mg/kg/day (total 1.43 g/kg) for the female rat and 149 mg/kg/day (total 3.28 g/kg) for the male. All female rats given the dosage of 100 mg/kg/day (22 doses, total 2.20 g/kg) died between 41 and 53 days after the start of treatment, whereas 38% of the males died between 50 and 73 days. Pathologic changes in treated rats were large liver, accentuation of the hepatic lobular markings, and atrophy of thymus and spleen. Microscopically, hepatic changes were characterized by congestion, fatty metamorphosis, and multifocal liquefactive necrosis. Male rats given 100 mg/kg/day and dying after 90 days had subacute to chronic hepatitis with marked focal proliferation of bile ducts. Exposure to Firemaster FF-1 may produce atypical liver nodules in the rat as early as 6 months after they were first given the preparation. Marked hepatotoxic effect persisted in surviving rats when examined after 6 months.

Administration, Oral↗
PubMed1978

The distributed response of complex branching duct networks.

We describe an efficient method for stimulating the distributed response of complex asymmetrically branching networks which satisfy requirements of network self-consistency. Individual tree links may be dispersive and lossy. As a case in point we simulate the response of the human lung, and characterize the variations in pressure with frequency, path, and position. The effects of tree asymmetry are found to be significant above 100 Hz in the air-filled lung.

Acoustics↗
PubMed1978

Effects of polybrominated biphenyls (PBB) on immune response in rodents.

Studies were performed to investigate the effects of FireMaster FF-1, a chemical fire retardant consisting of a mixture of polybrominated biphenyls (PBB), on immune functions in mice and rats. Animals received 22 daily treatments of 0.03, 0.3, 3.0, or 30 mg PBB/kg body weight in a period covering 30 days. PBB exposure severely depressed cell mediated immunity in both mice and rats at the higher dosage levels as indicated by depressed responsiveness of splenic lymphocytes to mitogenic stimulation by polyclonal T-cell activators. Additionally, humoral immunity was depressed in mice at the 30.0 ppm dosage level. Assays for humoral immune functions included antibody production, serum immunoglobulin levels, and mitogenic stimulation of splenic lymphocytes to a polyclonal B-cell activator. These studies indicate that PBB exposure can lead to suppression of both humoral and particularly cell-mediated immune responses.

Animals↗
PubMed1978

Experimental infection with Schistosoma intercalatum (Fisher, 1934) in the chimpanzee (pan troglodytes) and the gibbon (Hylobates lar).

Two young chimpanzees (Pan troglodytes) and two adult gibbons (Hylobates lar), each exposed to 1,000 cercariae of Schistosoma intercalatum (Cameroon), were examined at 79 and 82 wk and 61 and 69 wk, respectively, post-infection. Based upon worn returns and tissue egg deposits, these primates can be employed as hosts for experimental schistosomiasis intercalata. However, no histopathology was detected in the urogenital system.

Animals↗
PubMed1978

Natural history of papillary lesions of the urinary bladder in schistosomiasis.

Variable epithelial hyperplasia was observed in urinary bladder of nine capuchin monkeys (Cebus apella) when examined at cystotomy 94 to 164 weeks after infection with Schistosoma haematobium. These hosts were followed for 24 to 136 weeks postcystotomy to determine the status of bladder lesions in relation to duration of infection and to ascertain whether lesion samples removed at cystotomy reestablished themselves in autologous and heterologous transfers. There was involution of urothelial hyperplasia in eight of nine animals and no evidence for establishment of transplanted bladder lesions.

Animals↗