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Biomedical subjects

J A Monteiro

Publications and source records attributed to J A Monteiro.

5 recordsLinked to original sources

[Typhlitis].

Typhlitis, ileocecal syndrome and neutropenic enterocolitis are different terms, of what seems to be a localized infection in the cecal mucosa, caused by Clostridia species. Initially described in neutropenic patients, with leukaemias or after antineoplastic chemotherapy, typhlitis can also occur in HIV patients, as in the present case report. Their early diagnosis is not easy, becoming particularly difficult in immunodepressed patients, whom can be affected by multiple problems causing similar symptoms. Treatment, as well, can be problematic, and aggressive medical treatment should be pursued. If some patients may need surgery, others might be submitted to unnecessary surgical procedures. In the long range, medical control of this situation can be very difficult.

Enterocolitis

[Report of a case of megakaryoblastic leukemia].

We diagnosed a 20 year old young girl, with clinical and laboratorial evidence of pancytopenia, an acute megakaryoblastic leukemia. The difficulty in arriving at this conclusion was only surpassed with the help of monoclonal antibodies. With the presentation of this case we approach the problematics in obtaining the diagnostic of the megakaryoblastic leukemia. This is fundamental, owing to the possibilities of morphological presentation under undifferentiated blasts or of the type M1 or L2 (FAB).

Adult

[Three years of AIDS. Experience of the Curry Cabral Hospital with HIV infections (1985-1988)].

The AA. present a retrospective study on their experience with HIV positive patients, followed on the Infectious Diseases Department of the Hospital Curry Cabral, in Lisbon. This study was done in 90 patients seen since 1985 till March 1988. From the 90 patients, 81 were HIV--1 positive, 6 HIV--2 and 3 HIV1 + HIV2 positives. It is presented their distribution by sex (Male = 97.8%), age (mean--36.5 years), risk groups (homosexuals--64.4%, heterosexuals--21.1%, IVDA--7.7%, blood-related--5.6%), and their Walter Reed and CDC classifications. It is emphasised the increasing incidence of infected people along the years and an unexpected high rate of heterosexual males infected. It is also pointed the incidence of Kaposi (22%), Pneumocystis carinii pneumonia (55.6%), and Criptococosis (13.9%) in the WR6 group. The mortality rate was 31.3% for WR5 and 63.9% for WR6. We calculate some Relative Risks for clinical situations matched with risk groups and immunological status (meaning the T Helper lymphocitic count), and measured their statistical significance with the chi-square test. Besides the immunodeficiency, it was mentioned the associated lymphadenopathy and dermatological lesions, the HIV encephalopathy and the constitutional symptoms of the wasting syndrome.

Acquired Immunodeficiency Syndrome

[Nosocomial infections. Some aspects].

Nosocomial infection is not a recent problem. However, it presents nowadays as a serious issue, not only due to the associated morbidity and mortality but also due to the economic burden on hospitals. The increased susceptibility of patients and the increased resistance to antibiotics by bacterial agents are important factors in the present situation. Among the different nosocomial pathogens, methicillin-resistant Staphylococcus aureus and Clostridium difficile are two of the most distressing for hospitals worldwide. Knowledge of their epidemiology, pathological and clinical particularities and treatment are fundamental in the observation and control of these infections. As a result of my recent experience in two teaching hospitals in the United States of America, I have decided to write the present paper.

Bacterial Infections