Biomedical subjects

J A Mahoudeau

Publications and source records attributed to J A Mahoudeau.

44 records · Page 3Linked to original sources

PubMed1970

Dynamics of androgen metabolism in women with hirsutism.

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Adrenal Glands↗

PubMedDate not supplied

[Antiandrogenic effect of spirolactones: different mechanisms of action (author's transl)].

The spirolactones decrease the plasma testosterone levels in men. They also inhibit the specific dihydrotestosterone binding to rat prostate, and have no effect on 5 alpha-reductase. The spirolactones are antiandrogenic drugs, acting at several levels.

Androgen Antagonists↗

PubMedDate not supplied

[Study of Leydig cells and gonadotropin activity in 14-18 days old fetal mouse (author's transl)].

An organ culture system has been developed for mouse embryo testes and pituitaries at 14-18 days of gestation. The testosterone (T) production by fetal testes has been measured by RIA in the culture medium: it increases from day 14 to day 18 and may be specifically stimulated by ovine LH and hCG. Fetal pituitaries in culture release a gonadotropin activity at 16 and 18 days (not found at 14 days), which is detectable by an heterologous RIA of LH and by a significant increase in T production from age-matched testes in co-culture. The 18-days old pituitaries respond to synthetic LH-RH by an enhanced production of immunologically and biologically active LH.

Animals↗

PubMedDate not supplied