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Biomedical subjects

J A LEWIS

Publications and source records attributed to J A LEWIS.

At least 19 recordsLinked to original sources
PubMed1963

CLINICAL EVALUATION OF A NEW ANTIHYPERTENSIVE AGENT: W583 (MEBUTAMATE).

W583 (Mebutamate) was administered to nine male hypertensive patients in doses up to 2400 mg. per day in an attempt to lower the blood pressure. No other drug was used concurrently. The blood pressure was lowered in two patients only; and the drug was found to be without effect in the remaining seven patients. No postural effect or alteration in pulse was observed. Mild drowsiness was the only effect observed that might be attributable to W583. The duration of treatment varied between three days, in a patient who then developed delirium and a sudden rise in blood pressure, to five months in one other patient. This drug appears to have a very limited place in the treatment of hypertension. Lack of significant demonstrated antihypertensive effect in seven of nine patients suggested that double-blind control studies are not warranted.

Antihypertensive Agents↗
PubMed1962

A survey of cardiac infarctions: hospital experience.

A study of patients with cardiac infarction, treated in hospital between 1950 and 1954 and followed up to the present, is reported. One hundred and forty-two patients suffered 169 attacks. In 95 attacks, the patients received anticoagulant therapy, with 15 acute deaths. Fifty-six were not so treated; among these there were 21 deaths. The rate of survival was best in younger patients with their first episode of infarction, without preexisting hypertension, cardiac failure, or systolic blood pressure persistently below 100. Angina preceding infarction disappeared in one-half of the subjects after the episode; half the survivors suffered recurrent myocardial infarction within five years. Moderate hypertension had no effect upon immediate or 10-year survival. No patient received long-term anticoagulant therapy. Of the survivors of acute infarction, 16 died in the first year after the acute attack, nine in the second year, nine in the third, six in the fourth and five in the fifth. At the end of five years, 51 subjects had survived 60 episodes. At the end of 10 years, 43 living patients had sustained 45 myocardial infarctions.

Angina Pectoris↗