Biomedical subjects

J A Kruper

Publications and source records attributed to J A Kruper.

3 recordsLinked to original sources

PubMed1994

Building Internet accessible medical education software using the World Wide Web.

We describe work to enhance existing software protocols and develop a suite of new software utilities based upon a set of standards known as the World Wide Web (WWW). Specifically, we have developed an effective X-windows based WYSIWYG WWW browser/editor and a prototype for integrated wide-area authentication and authorization support for delivery and maintenance of WWW service. These software development activities, along with parallel work in content development, are empowering individuals to better use the Internet as a resource to easily author, publish, and access materials. As an illustrative application, we describe one Web-based self-instructional unit designed to increase users' knowledge of hazardous substances in the environment. This on-line monograph was adapted from a series of paper-based case studies developed by the Agency for Toxic Substances and Disease Registry of the U.S. Department of Health & Human Services. The on-line version illustrates many of the innovative features provided by the Web, and demonstrates how such materials can significantly impact medical education at all levels.

Computer Communication Networks↗

PubMed1993

The Centennial Patient Care Program: binding patient, student, and clinician-teacher in a learning triad.

The University of Chicago is building a technology-based clinical environment to provide a longitudinal experience for patients and medical students. This environment uses an open systems, computer communication and information support network to forge an interactive education and care relationship between patient, medical student, and clinical faculty mentor. The project proactively addresses some of the most important activities required to reform both the health care and medical education systems: anchoring patient care in a generalist setting; educating medical students in outpatient medicine; fostering primary care as a career choice; and using medical informatics as a tool rather than as an end in itself. Moreover, the project effectively deploys concepts such as patient-centered education, student-based learning, and mentored teaching experiences. This paper reports the curricular, pedagogical, and technological motivations and framework under which the project was designed, and describes the process that a patient-student-clinician/teacher triad will experience as participants in this program.

Ambulatory Care Facilities↗

PubMed1988

Herpes simplex virus virion host shutoff function.

Herpes simplex virus (HSV) virions contain one or more functions which mediate the shutoff of host protein synthesis and the degradation of host mRNA. HSV type 1 (HSV-1) mutants deficient in the virion shutoff of host protein synthesis (vhs mutants) were isolated and were found to be defective in their ability to degrade host mRNA. Furthermore, it was found that viral mRNAs in cells infected with the vhs 1 mutant have a significantly longer functional half-life than viral mRNAs in wild-type virus-infected cells. In the present study we have mapped the vhs1 mutation affecting the virion shutoff of host protein synthesis to a 265-base-pair NruI-XmaIII fragment spanning map coordinates 0.604 to 0.606 of the HSV-1 genome. The mutation(s) affecting the functional half-lives of host mRNA as well as the alpha (immediate-early), beta (early), and gamma (late) viral mRNAs were also mapped within this 265-base-pair fragment. Thus, the shutoff of host protein synthesis is most likely mediated by the same function which decreases the half-life of viral mRNA. The shorter half-life of infected-cell mRNAs may allow a more rapid modulation of viral gene expression in response to changes in the transcription of viral genes. Interestingly, the vhs1 mutation of HSV-1 maps within a region which overlaps the Bg/II-N sequences of HSV-2 DNA shown previously to transform cells in culture. The possible relationship between the transformation and host shutoff functions are discussed.

Animals↗