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Biomedical subjects

J A Hudson

Publications and source records attributed to J A Hudson.

71 records · Page 4Linked to original sources
PubMed1985

Successful medical treatment of pulmonary petriellidiosis.

We have reported a case with culture and serologic evidence of pulmonary infection with Petriellidium boydii treated with intravenous miconazole, resulting in dramatic symptomatic improvement, stabilization of x-ray changes, and clearing of Petriellidium on sputum culture. Although no biopsy was done to establish absolute diagnosis of invasive disease, and thus the results of this case cannot be taken as an absolute criterion for therapy, this may represent the first medical cure of pulmonary infection with this agent.

Diagnosis, Differential↗
PubMed1967

The cell surface.

Explore the source record for details and available documents.

Cell Biology↗
PubMedDate not supplied

Clinicopathologic effects of a 21-aminosteroid compound (U74389G) and high-dose methylprednisolone on spinal cord function after simulated spinal cord trauma.

A model simulating acute-compressive spinal cord trauma at the second lumbar spinal cord segment (100 g, 300 seconds) was used to evaluate the efficacy of a vehicle control, methylprednisolone sodium succinate (MPSS), and a 21-aminosteroid compound (U74389G). Dogs were allocated into one of five treatment groups (A to E) using ultrasonographic determination of spinal cord diameters to ensure even distribution of spinal cord diameters among the treatment groups. Initial dosages of the vehicle control (A), methylprednisolone (30 mg/kg of body weight) (B), or U74389G (30 mg/kg, 3 mg/kg, or 10 mg/kg of body weight) (C, D, or E, respectively) were administered intravenously 30 minutes after trauma. Dosages were reduced by one-half for 2 and 6 hour treatments. Then every 4 hours for 42 hours, dosages were reduced one-third and one-sixth from the original dose of methylprednisolone and U74389G, respectively. Neurological examinations were performed daily for 21 days. Histopathological examination of the traumatized spinal cord showed malacic and degenerative lesions. Although significant differences in some portions of the neurological and histopathologic examinations were observed, clinical efficacy for MPSS and U74389G could not be established in this model.

Acute Disease↗
PubMedDate not supplied

Color flow Doppler imaging and Doppler spectral analysis of the brain of neonatal dogs.

Doppler ultrasonography was performed on the cerebral arteries of 19 neonatal dogs. Vascular structures were identified using anatomic preparations of brains pre-injected with a radiopaque silicone rubber product and cleared using a modified tissue clearing technique. Brain sections were subsequently radiographed or examined under a stereomicroscope. Color flow Doppler imaging was used to facilitate positioning of the Doppler calipers for measurement of peak systolic velocity, minimum diastolic velocity, and resistance index. Blood flow velocities in the internal carotid and middle cerebral arteries were lower when measured in transverse images than in sagittal images. The rostral cerebral arteries could be measured using either plane but values obtained from different locations or using different methods of measurement were statistically different. Blood flow velocities generally increased during the first month after birth. Arterial signals were diphasic with flow throughout diastole. Resistance indices most often were between 0.6 and 0.7 and did not exceed 0.86.

Animals↗
PubMedDate not supplied

Low-field magnetic resonance imaging of the equine tarsus: normal anatomy.

The objective of this study was to define the normal gross anatomic appearance of the adult equine tarsus on a low-field magnetic resonance (MR) image. Six radiographically normal, adult, equine tarsal cadavers were utilized. Using a scanner with a 0.064 Tesla magnet, images were acquired in the sagittal, transverse and dorsal planes for T1-weighted and the sagittal plane for T2-weighted imaging sequences. Anatomic structures on the MR images were identified and compared with cryosections of the imaged limbs. Optimal image planes were identified for the evaluation of articular cartilage, subchondral bone, flexor and extensor tendons, tarsal ligaments, and synovial structures. MR images provide a thorough evaluation of the anatomic relationships of the structures of the equine tarsus.

Animals↗
PubMedDate not supplied

Computed tomography of the normal lumbosacral intervertebral disc in 22 dogs.

Computed tomography of the lumbosacral spine was performed on 22 purpose-bred, medium-sized hound dogs between 1 and 6 years of age. Images were evaluated to determine the degree of disc bulge. All dogs were neurologically normal. Dogs were imaged in dorsal recumbency with the pelvic limbs variably extended. Sagittal reconstructions were made from transverse images. The mean (+/-SD) width of the mid-portion of the L7-S1 intervertebral disc was 0.5 +/- 0.07 cm (range 0.33-0.62 cm). All L7-S1 intervertebral discs were dorsally convex, with the mean bulge measuring 0.25 +/- 0.07 cm (range 0.17-0.50 cm). The height of the vertebral canal at L7-S1 was 0.91 +/- 0.11 cm (range 0.68-1.15 cm). The mean percentage of the vertebral canal occupied by the bulge was 26.89 +/- 5.05% (range 20.74-43.08%). Mild bulging of the L7-S1 intervertebral disc can be present without associated neuropathy in medium-sized dogs.

Animals↗
PubMedDate not supplied

A retrospective study of canine hip dysplasia in 116 military working dogs. Part I: Angle measurements and orthopedic foundation for animals (OFA) grading.

The progression of hip dysplasia was investigated in 116 military working dogs. Serial pelvic radiographs were graded for degree of dysplasia and degenerative joint disease (DJD). Norberg angles, angles of inclination, and joint space widths were measured. There was a significant correlation between the Norberg angle and the degree of dysplasia (p less than 0.0001). Angles of inclination and joint space width measurements did not demonstrate a correlation to canine hip dysplasia. Dysplastic dogs had a significant estimated risk for development of DJD compared to normal dogs (p less than 0.0001; odds ratio of 70.2). Dogs with normal hip conformation at 24 months of age or older did not develop moderate nor severe DJD.

Animals↗
PubMedDate not supplied

A retrospective study of canine hip dysplasia in 116 military working dogs. Part II: Clinical signs and performance data.

The progression of hip dysplasia was investigated in 116 military working dogs. Medical records were reviewed for any clinical history of hind-limb lameness. Pelvic radiographs were studied for evidence and degree of hip dysplasia, degenerative joint disease, or both. The number of months each dog worked was determined. Each dog's age at termination from service and cause of death (or euthanasia) were recorded. The mean months of work for normal and dysplastic dogs were evaluated using the Student's t-test. No significant difference was found in the total number of months worked between normal and dysplastic dogs (p greater than 0.05).

Animals↗