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Biomedical subjects

J A Gruwez

Publications and source records attributed to J A Gruwez.

At least 19 recordsLinked to original sources
PubMed1999

The importance of magnetic resonance imaging in the diagnosis and treatment of diffuse lymphangioma.

In this study, we will investigate the importance of MRI in the diagnosis and treatment of diffuse lymphangioma. Twenty-nine patients with lymphangiomas were treated at the U.Z. Leuven between March 1988 and September 1997. They all underwent a total surgical excision of the lesion. A global recurrence rate of 34.45% corresponds with a recurrence rate of 30.76% found in literature. In our study, a remarkable difference in recurrence rates is noticed between cystic hygroma (5/19 patients or 26.39%) and the more diffuse types of lymphangioma (5/10 patients or 50%). On three patients, preoperative MRI was performed. All these illustrate the important role of MRI in the diagnosis of lymphangioma, namely the characteristic appearance of the lesions on T1- and T2-weighted images and the better visualization of the lymphangioma extent. In line with the high recurrence rates of diffuse lymphangiomas and the advantages of MRI of these lesions, the role of MRI in the treatment of diffuse lymphangiomas is discussed.

Adolescent↗
PubMed1999

[Hierarchical structures in European countries].

The current form of organization and structure dates from the beginning of the 20th century, but now developments show a trend toward teamwork, where work, power, and authority are evenly distributed among several persons and carried out correspondingly. According to a survey of 11 out of 16 countries in Europe, large surgical institutions are organized according to the hierarchic principle. In Austria, Belgium, and the Netherlands both types of organization exist, and only in Luxembourg, Ireland, and Great Britain does the cooperative system exist. The latter is also preferred in smaller and medium-sized hospitals, and in private institutions as well. This system appears to better correspond to the requirements of economics and specialization.

Europe↗
PubMed1998

[Current status and future prospects for specializing in surgery in united Europe].

Specialisation within surgery is unavoidable, as it is in other disciplines. Motives and drawbacks are mentioned. The current situation in Europe is confused. However, progress in training is encouraging. The UEMS, the sections, and the boards are the preferred instruments for stimulation and harmonisation of training, C. M. E., quality control and peer review and of visitation of centres. The envelope concept of surgery seems to be the best answer to the structural problem of the distinct specialties within surgery. The duration and length of the common trunk in these specialties remains a difficult issue. The future of surgery requires the implementation of a number of assignments by the ACMT, the UEMS, its sections, boards and divisions.

Career Choice↗
PubMed1996

Anal sphincter reconstruction with the gluteus maximus muscle: anatomic and physiologic considerations concerning conventional and dynamic gluteoplasty.

Myoplasties have acquired an important place in anal sphincter repair. The use of the gluteus maximus muscle for sphincterplasty was reported initially in 1902. However, in 1952, the gracilis sphincterplasty became more popular because of the accessibility of this muscle. Unfortunately, continence rates, especially after graciloplasty, remained unpredictable because of inability to maintain muscle contraction despite training programs. Training should induce a shift in muscle fiber type distribution toward a more fatigue-resistant composition, with predominance of type I fibers. In order to obtain a more pronounced adaptation in the contractile, histochemical, and metabolic properties of muscle fibers, postoperative intermittent long-term stimulation of the graciloplasty was performed. As these results and the results of dynamic cardiomyoplasty with an implantable myostimulator proved to be successful, implantable pulse generators were used after graciloplasty. Subsequently, continence rates after graciloplasties improved significantly. These data encouraged us to perform dynamic gluteoplasties for anal sphincter repair. This paper presents the results in 7 patients treated by conventional and 4 patients treated by dynamic gluteoplasty. Advantages and disadvantages of gluteoplasty were compared with those of graciloplasty. The neurovascular pedicle of the gluteoplasty underwent less traction after transposition compared with the graciloplasty based on cadaver studies. Gluteus muscle transfer far exceeded the amount of muscle tissue of a normal anal sphincter despite muscle atrophy after transposition. This guaranteed a contractile muscle cuff around the anal canal in contrast to the tendinous sling after graciloplasty. Because of the excellent vascularization of the muscle, microperforations of the rectal mucosa caused by submucosal dissection were sealed, and implantation of electrodes and a pulse generator in one surgical intervention was well tolerated. The myoplasty induced a double curvation of the anal canal in contrast to the graciloplasty, which enhanced the natural anorectal angle. Patient evaluation revealed continence for stool in 9 of the 11 patients; 7 of the 11 patients also were continent for liquids, among them all of the patients who had undergone dynamic gluteoplasties. Mean basal pressure after dynamic gluteoplasty was 49 mmHg, which is lower than the reported mean basal pressure (62 mmHg) during stimulation after dynamic graciloplasty. Squeeze pressure after gluteoplasty, with or without stimulation, proved to be similar to or higher than that obtained in dynamic graciloplasty. Comparing our results of conventional gluteoplasty with the results of graciloplasty prior to stimulation, higher pressures were obtained by the gluteoplasty, especially in squeeze pressures. In the last 5 patients intraoperative pressure measurements were used to restore the optimal resting length of the muscle after transposition. An intraluminal pressure of at least 40 mmHg during rest and 80 to 120 mmHg during stimulation should be obtained to guarantee a future continent sphincter.

Adult↗
PubMed1996

CME in Belgium.

Explore the source record for details and available documents.

Accreditation↗
PubMed1995

Neurovascular intact muscle transposition for anal sphincter repair. Experimental model and experience with dynamic pacing.

PURPOSE: To study muscle behavior for anal sphincter repair, radiologic, manometric, and histologic techniques in a dog animal model have been used. Special attention was given to the problem of resting length of the transposed muscle. METHODS: The semitendinosus muscle of the dog could be transposed successfully to create a new anal sphincter based on an intact neurovascular pedicle. The parallel-fibered muscle was split at its distal end and encircled around the anal canal. Manometry was performed intraoperatively and postoperatively. A sufficiency high basal and squeeze pressure had to be obtained intraoperatively to guarantee a final continent neosphincter. This could be realized by a progressive stretching of the muscle until maximum squeeze is reached. In one animal a pacemaker was implanted, and postoperatively a fixed sphincter stimulation protocol was started. Muscle biopsies of the normal anal sphincter and the neosphincter were taken. RESULTS: 1) Muscle transposition gave a high degree of continence in this experimental model, with a mean resting pressure of +/- 40 mmHg and a mean squeezing pressure of +/- 73 mmHg. 2) Electric stimulation of the neosphincter in one animal influenced the resting pressure but not the squeeze pressure. 3) Muscle fiber type composition changed toward a slow fiber type composition after transposition of the fast muscle and even more after stimulation. CONCLUSIONS: 1) Creation of a muscle cuff around the anal sphincter can substitute normal anal sphincter. 2) Adequate stretch of muscle fibers is essential for continence. 3) Electrical pacing helps preserve resting tension and subsequent continence.

Anal Canal↗
PubMed1995

Primary leiomyosarcoma of the diaphragm.

Primary leiomyosarcoma of the diaphragm is extremely rare and only five cases have so far been reported. In the early stages clinical signs are scarce and diagnosis is difficult. The advent of MR-imaging has helped in detecting the origin of a diaphragmatic tumour and its relationship to the adjacent tissues. The highly malignant character of this tumour accounts for the poor prognosis even when radical surgery is performed.

Diagnosis, Differential↗
PubMed1993

[Functioning of the tube stomach following esophagus resection for carcinoma].

A retrospective study was made of the functional results of the tube stomach created in 80 patients after oesophageal resection because of carcinoma to restore the continuity. The study concerned patients who had survived the operation for longer than 18 months without indications of tumour recurrence or metastases and of whom clinical and endoscopical data of 3 months and one year after the operation were available. The functional results of the tube stomach may be regarded as good because one year postoperatively 86% of the patients were classified as excellent or very good according to the modified Visick classification. Dumping (18%), a sensation of fullness (26%) and diarrhoea (28%) were frequent complaints, occurring mostly soon after the operation. After one year these complaints are almost completely gone. Three months postoperatively, 19% of the patients had a stenosis of the anastomosis that required one or more dilatations. Reflux oesophagitis is the major late complication, leading to late stricture of the anastomosis. Reflux oesophagitis was encountered in 43% of the patients with an intrathoracic anastomosis and in only 6% of those with a cervical anastomosis; the difference is statistically significant. After one year, a stenosis due to reflux was encountered in four of the 30 patients (13%) with an intrathoracic anastomosis and in only one of the 50 patients (2%) with a cervical anastomosis. These results show that from the functional point of view, as well, the stomach is a good substitution organ after oesophageal resection, provided the anastomosis is created in the neck.

Adult↗
PubMed1992

Stenosis of the small bowel after blunt abdominal trauma.

At the Catholic University of Louvain, between 1950 and 1990, two patients were treated for blunt abdominal trauma resulting in stenosis of the small bowel. One patient underwent partial resection of the small bowel 6 weeks after the trauma was sustained. The other was admitted for surgery 26 years after a blunt abdominal trauma. Surprisingly, the stenosis of the small bowel was accompanied by a ureteral obstruction due to fibrosis and terminal hydronephrosis.

Abdominal Injuries↗
PubMed1991

[Anal-perineal lesions in Crohn's disease].

Radical surgery preserving the sphincter was performed in 190 patients with anal Crohn's disease and achieved good results in 163 cases. 28 patients had a restorative sphincteroplasty. Anal Crohn's disease should be treated according to the same surgical criteria than the other localizations of the disease.

Anus Diseases↗
PubMed1991

Lymphedema of the leg associated with rheumatoid arthritis.

A 14-year-old boy with a two year history of seronegative rheumatoid arthritis developed left leg lymphedema and subsequently a severe episode of lymphangitis. The diagnosis of "rheumatoid lymphedema" was confirmed by lymphscintigraphy and conventional lymphography. Treatment consisted of bedrest and antibiotic drugs. When the signs of inflammation had subsided, therapy with corticosteroids was started with improvement of both joint pain and leg swelling. Whereas lymphedema associated with rheumatoid arthritis has been described in the upper limb of adults, to our knowledge this is the first report of the coexistent condition in the lower leg of a child.

Adolescent↗
PubMed1990

Potency and selectivity of the aromatase inhibitor R 76,713. A study in human ovarian, adipose stromal, testicular and adrenal cells.

The effects of R 76,713 on steroidogenesis were studied in primary cultures of four different human cell types, i.e. ovarian granulosa cells, adipose stromal cells, testicular cells and adrenal cells. In human granulosa cells aromatization of [1 beta, 2 beta-3H]androstenedione (as measured by the release of tritiated water) showed a Km (Michaelis constant) of 78 nM. R 76,713 competitively inhibited aromatization with a Ki (dissociation constant of the enzyme-inhibitor complex) of 1.6 nM. In human adipose stromal cells aromatization was measured by following the conversion of androstenedione to estrone and 17 beta-estradiol. In this system a Km for aromatization of androstenedione of 10.8 nM was found. R 76,713 again showed competitive kinetics with a Ki-value of 0.14 nM. In human testicular cells the synthesis of the androgens testosterone, androstenedione and dehydroepiandrosterone was only inhibited by drug concentrations exceeding 10(-6) M. At 10(-5) M of R 76,713, steroid concentrations were lowered to 56, 64 and 81% of the control for testosterone, androstenedione and dehydroepiandrosterone respectively. Concomitantly, a slight increase in the levels of pregnenolone (138% of the control) and progesterone (133% of the control) was seen. In human adrenal cells the synthesis of cortisol and aldosterone was slightly affected by R 76,713 also at concentrations exceeding 10(-6) M. At 10(-5) M of R 76,713 the concentrations of cortisol and aldosterone were lowered to respectively 59 and 51% of the control. At the same drug concentration the precursors 11-deoxycortisol and 11-deoxycorticosterone rose to 189 and 147% of the control. These results show that in primary cultures of human cells, R 76,713 is a very potent aromatase inhibitor with a selectivity of at least 1000-fold compared to other steps in steroidogenesis.

Adipose Tissue↗
PubMed1989

Sutureless large bowel anastomosis: European experience with the biofragmentable anastomosis ring.

Sutureless colonic anastomosis using a biofragmentable anastomosis ring (BAR) has been evaluated in a prospective randomized comparison with sutures and staples for elective colorectal surgery. One hundred and one patients underwent BAR anastomosis, 85 a sutured anastomosis, and 16 a stapled anastomosis. There were two anastomotic leaks in the patients undergoing BAR anastomosis, seven in patients having a sutured anastomosis, and one in a patient who had a stapled anastomosis. Wound infection occurred in ten BAR patients, ten sutured patients and no stapled patient. There was no statistically significant difference in these or in other postoperative complications between the groups. The BAR was easy to use and is a safe alternative to sutures and staples for large bowel anastomosis.

Adolescent↗