Biomedical subjects

J A Gorter

Publications and source records attributed to J A Gorter.

39 records · Page 3Linked to original sources

PubMed1989

Paradoxical sleep deprivation does not affect neuronal excitability in the rat hippocampus.

Before, during and after paradoxical sleep deprivation, field potentials, evoked in the CA1 region and in the fascia dentata of the hippocampus by means of paired pulse stimulation, were measured. Paradoxical sleep deprivation was applied for 3 days, using the platform and the pendulum technique. No changes were observed on evoked field potential amplitude, population spike or paired pulse depression during and after the deprivation period. These results suggest that the neuronal excitability in the rat hippocampus, measured with the evoked potential technique, does not change as a result of paradoxical sleep deprivation.

Action Potentials↗

PubMed1986

Kindling of the hippocampus induces spatial memory deficits in the rat.

Since kindling produces electrophysiological and morphological changes in the brain area stimulated, it may well affect behavioural functions dependent on the kindled area. Using an 8-arm maze, it was found that hippocampal kindling can induce specific memory deficits in spatial tasks. Reference (long-term) memory as well as working (short-term) memory were impaired. The largest impairment was observed during the period in which generalized convulsions occurred. Working memory but not reference memory impairment was reversible. Hippocampal kindling may be a useful experimental model for investigating behavioural deficits correlated with epileptogenesis.

Animals↗

PubMedDate not supplied

Hippocampal neuronal responsiveness to different neurotransmitters in the adult rat after neonatal interference with noradrenaline transmission.

In order to test the functional significance of noradrenergic neurotransmission for brain maturation, rat pups were injected daily with clonidine from 8-21 days of postnatal life. In adulthood, single cell responses to microiontophoretically applied neurotransmitters were studied in different layers of the hippocampus. No significant differences were found in neuronal responsiveness to glutamate, GABA, or acetylcholine in the hippocampus of clonidine-treated rats as compared with age-matched controls. However, there was a significantly stronger depression of glutamate-evoked activity of CA1 pyramidal neurons by noradrenaline in the clonidine-treated rats.

Acetylcholine↗