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Biomedical subjects

J A Fatani

Publications and source records attributed to J A Fatani.

27 records · Page 2Linked to original sources

A histochemical study on the innervation of the pancreas of the one-humped camel (Camelus dromedarius).

Autonomic innervation of the pancreas of the camel has been studied using histochemical techniques for the demonstration of adrenergic and cholinergic (acetylcholinesterase-positive) nerves. Both extrinsic and intrinsic innervation of the pancreas were found. Distinct peri-acinar, perivascular, peri-insular and periductal plexuses were found as well as both adrenergic and cholinergic ganglia. The role of the autonomic nerves in the synthesis and release of insulin, glucagon and somatostatin is discussed.

Adrenergic Fibers↗

Methotrexate neuroenteropathy--a histochemical study.

10 mg/kg Methotrexate was injected daily for 5 d a week for a total period of 3 weeks and its effect on autonomic nerve profiles of jejunum was studied using histochemical methods. Initially (after 5 doses in a week) partial degeneration of adrenergic and cholinergic nerve supply was observed. Prolonged treatment (15 does in 3 weeks) was responsible for disappearance of about 30% of adrenergic and 50% of cholinergic nerve profiles. Early degenerative changes in the cholinergic nerve cells of the intestinal plexuses was also noted.

Acetylcholinesterase↗

Parasympathetic innervation of the thymus: a histochemical and immunocytochemical study.

The presence of parasympathetic nerve supply to the thymus has been demonstrated by histochemical and immunocytochemical methods using antibodies against cholineacetyl transferase. Fine nerve fibres have been observed both in the thymic parenchyma and around the blood vessels. The role of the parasympathetic nerve supply to the thymus is briefly discussed.

Acetylcholinesterase↗

Use of glyoxylic acid in the demonstration of autonomic nerve profiles.

2% glyoxylic acid buffered to pH 7 could be used to improve the localization of cholinergic, adrenergic and nonspecific nerve profiles both in frozen sections and stretch preparations. The results are better than those obtained by conventional techniques, exhibiting the distinct reactions, with the least possible background and diffusion. The results are quickly obtained.

Animals↗

Rate of growth of lower incisor teeth in the adult white rat.

A single dose of 14C was given to adult rats and the animals were sacrified 4 days later. The thickness of dentine formed during this period was measured in radioautographs of incisor teeth. It appeared that the thickness of dentine laid down per day was 15 microns. This rate was about one seventh of the rate of growth in immature incisors. No new dentine formation was observed in molar teeth.

Animals↗

Horseshoe lung with multiple congenital anomalies. Case report and review of the literature.

A detailed radiologic and anatomic study of a 20-week-old fetus is presented. In addition to conventional radiography, various contrast medium injection techniques were used. The findings were followed up at autopsy. The fetus showed multiple congenital abnormalities comprising phocomelia, horseshoe lung, horseshoe kidney, urethral stenosis with megacystis, bilateral hydronephrosis, hydroureters, imperforate anus, and a single tracheo-esophageal tube (persistent esophago-trachea). The association of horseshoe lung with persistent esophago-trachea, microurethra, megacystis, bilateral hydroureters, hydronephrosis and phocomelia is, we believe, the first ever to have been recorded in the literature. Twenty-one cases of horseshoe lung have been reported in the literature. These cases were reviewed and a comparison with the present case is presented. The embryologic basis for these anomalies is also briefly discussed.

Abnormalities, Multiple↗

Myelographic study of the spinal cord ascent during fetal development.

To assess the length of the spinal cord relative to the vertebral column during fetal development, we performed translumbar myelograms on 340 spontaneously aborted fetuses. Of these, 146 were selected for study. There were 76 males and 70 females, with fetal age ranging from 7 to 33 weeks. Significant variation in the level of spinal cord termination was found in fetuses between 12 and 25 weeks gestational age. In fetuses between 25 and 33 weeks gestational age, the cord ended at or above the third lumbar vertebra.

Embryonic and Fetal Development↗