Biomedical subjects
J A Falk
Publications and source records attributed to J A Falk.
A study of HL-A antigen phenotype in rheumatic fever and rheumatic heart disease patients.
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The role of the mixed lymphocyte culture reaction in the stimulation of antibody production by human lymphocytes in vitro.
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Assessment of the cellular immune response to HL-A antigens in human renal allograft recipients.
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HL-A antigens in clinical transplantation.
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A study of cell-mediated immunity to transplantation antigens in human renal allograft recipients.
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Reactivity of nonsensitized thymocytes to antigen: release of specific lymphocyte-activating substances.
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Lymphocyte-activating factors released in vitro by sensitized and nonsensitized human lymphocytes.
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Mixed leukocyte reaction in rheumatoid arthritis.
The mixed leukocyte reaction (MLR) responses of 29 patients with classic rheumatoid arthritis (RA) were compared with those of 24 age- and sex-matched healthy controls. Pools of stimulating cells were selected to include the major cross-reacting HL-A specificities. In pooled human serum the MLR response of the RA lymphocytes was significantly enhanced relative to the response controls (P less than 0.05). In autologous serum there was suppression of the MLR response in patients with RA which correlated with disease activity. The data suggest the presence of an intrinsically enhanced cellular reactivity of RA lymphocytes suppressed by serologic factor(s). The mechanisms of this enhancement of suppression are discussed.