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Biomedical subjects

J A Darras

Publications and source records attributed to J A Darras.

30 records · Page 2Linked to original sources
PubMed1986

[Results of primary surgery in the treatment of oropharyngeal cancer].

A homogeneous series of 106 cases of malignant tumor of tonsillar region was treated by first intention surgery. Treatment proposed for these patients with ulcerated or infiltration tumors often extending to pillars or to tongue was transmandibular buccopharyngectomy with curettage of glands and postoperative radiotherapy. Unadjusted survival rate at 3 years was 62% (T2 and T3) and at 5 years 35%. Clinical glandular enlargement, detected in 50% of cases, resulted in poorer prognosis, which decreased from 48% at 5 years to 25% in patients with histologic metastasis in lymph nodes.

Adult↗
PubMed1985

[Nasopharyngeal fibroma. Apropos of 29 cases].

This study is based on 29 juvenile angiofibroma, treated in 16 years. The average of age is 16.3 years but 24% of patients are over 20 years old. Scanner is the best mean to known the extension to the base of the skull and pterygoïd fossa. Angiography is not yet necessary and may be dangerous. The surgical approach is transmaxillary in most cases, with a very low average of recurrence = 10% and 1 post operative death.

Adolescent↗
PubMed1984

[Laser endoscopic treatment of cysts of the larynx and laryngoceles].

Twelve patients (8 with appendicular laryngeal cysts and 4 with laryngoceles) were treated in the ENT Unit, Lille between 1980 and 1983. Therapy was by laser through endoscopic guidance, and consisted of resection of the ventricular band to allow marsupialization of the cyst or mixed laryngocele in the endolarynx. Treatment was effective in all cases with restoration of a normal larynx within 2 to 3 months, even in patients with external laryngoceles. This method is of particular interest in bilateral lesions.

Adult↗
PubMed1984

[Our experience with the pectoralis major musculocutaneous flap. Apropos of 57 cases].

One of the most important technical advances in cervicofacial plastic surgery over the last few years is undoubtedly the use of the musculocutaneous flap from pectoralis major. A review of its application in 57 cases showed the flap to be of excellent viability (5% total necrosis of flap), and to offer multiple possibilities during primary surgery or that following radiation. Indications and excision limits can be extended, particularly in buccopharyngeal surgery, providing and appreciable functional gain (particularly disappearance of pain), even though long-term carcinologic advantages are deceiving.

Adult↗
PubMed1984

[Partial surgery of laryngeal vestibule cancer].

A retrospective study was conducted of 141 cases of laryngeal vestibule cancer treated by partial surgery between 1968 and 1977. Patients underwent either subglottic laryngectomy (105 cases) or subtotal laryngectomy with cricohyoidoplexy (36 cases). Operative mortality was 6.5 p. 100. Overall survival rate was 63 p. 100 at 3 years, with lymph node invasion in 32 p. 100 of cases, and a 3 year survival rate for group N of 71 p. 100 as against 50 p. 100 for group N+.

Epiglottis↗
PubMedDate not supplied

[Use of fast neutrons in the treatment of tumors of the salivary glands: rationale, review of the literature and experience in Orleans].

If low LET radiation therapy (photons, electrons), following radical microscopically and complete surgery can improve results in term of local control from 34 to 74% for salivary gland tumors, local control is more difficult to achieve in advanced tumors and only palliative treatment is usually attempted. In this survey, all the patient series treated worldwide were reviewed. They show an overall control rate of 31% with photon vs 64% with neutron therapy. A prospective randomised trial sponsored by the RTOG and the MRC published in 1988 and reviewed in 1993 showed an overall locoregional complete tumor clearance of 67% for neutrons and 17% for photons (P < 0.005), with 68% and 25% survival at two years for neutrons and photons respectively. This study was closed for ethical reasons. In Orleans, since 1987, 59 patients have been treated. At five years the persistent local control probability was 69.5%, the five-year crude survival probability 66% and the five-year tumor free survival probability was 64.5%. This review provides evidence that surgical treatment for salivary gland tumors should be limited to patients presenting a high likelihood of negative surgical margin and a small risk of facial nerve damage. Others patients should receive neutron radiation therapy alone as definitive treatment.

Combined Modality Therapy↗