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Biomedical subjects

J A Cates

Publications and source records attributed to J A Cates.

32 records · Page 2Linked to original sources
PubMed1991

Lovastatin inhibits gallstone formation in the cholesterol-fed prairie dog.

The efficacy of lovastatin, an inhibitor of hepatic cholesterol synthesis in the prevention of cholesterol gallstone formation, was evaluated in the prairie dog model. Two groups of animals were maintained on either nonlithogenic or 1.2% cholesterol-enriched chow for 21 days. Seven of the animals in each group received lovastatin, and the remaining six received only distilled water. All of the cholesterol-fed/water-treated animals had crystals and 83% had gallstones, but none of the cholesterol-fed/lovastatin-treated animals had gallstones and only three had microscopic crystals. These data indicate that lovastatin inhibits cholesterol gallstone formation in a diet-induced model of gallstone disease.

Animals↗
PubMed1991

Systemic treatment of multiple personality: response to a chronic disorder.

Multiple Personality Disorder (MPD) is a more and more frequently diagnosed disorder. In this article, MPD is considered the result of a dissociative defense in response to severe trauma during the formative period of personality formation. As the child dissociates to defend against the trauma, the fragments of personality develop as separate entities. The traditional focus of therapy is integration, or fusion of the various fragments of personality. The current article does not dispute this therapeutic goal, but does offer an alternative treatment process. Borrowing from the theoretical concepts of the family therapy literature, the person with MPD is described as a system. Therapy, then, must attempt to maintain balance within the system as a short-term goal, as well as striving for integration as a long-term goal. This article delineates the systemic approach, first from a theoretical, then a practical perspective. The concepts of coconsciousness (or awareness by all aspects of the system) and coexistence (a state of mutual cooperation between various personalities) are described, and fitted within the systemic model. Practical aspects of life with MPD, including activities of daily living and relationships, are then outlined within this model.

Activities of Daily Living↗
PubMed1991

Personality assessment of the prelingual, profoundly deaf child or adolescent.

Personality assessment of children and adolescents experiencing an early, profound hearing loss is hampered by the lack of instruments standardized and/or developed primarily for use with deaf clients. Further compounding the problem are the relatively few psychologists trained in and/or experienced with deaf personality assessment. This article reviews the rudimentary requirements for personality assessment with the deaf and critiques the available personality tests that are either used or useable in assessing the deaf.

Adolescent↗
PubMed1991

Self-concept in hearing and prelingual, profoundly deaf students. A comparison of teachers' perceptions.

A self-concept measure was administered to a group of 68 deaf students aged 8-19 years and a comparison group of 68 hearing students. Teachers for both of the groups completed observer reports of self-concept. Although tentative, the findings indicate that hearing teachers' perceptions of students' self-concepts are in closer agreement for hearing students than they are for deaf students. At the same time, the results show that deaf students do not appear markedly different from hearing students in their own reports of self-concept.

Adolescent↗
PubMed1990

Reoperative surgery for the morbidly obese. A university experience.

Patients who undergo surgery for morbid obesity are often subjected to reoperation for a wide array of indications. To evaluate outcome following revisional procedures, we reviewed the records of 32 such patients treated at UCLA between April 1986 and May 1989. Twenty-five women (78%) and 7 men (22%) with a mean age of 44 years underwent 76 reoperations (2.4 per patient) for complications of prior obesity surgery. Indications for initial surgical revision consisted primarily of metabolic derangements (12 patients) and weight-related problems (11 patients). In contrast, indications for the patients' final surgical procedure were commonly for bowel obstruction (41%), intra-abdominal sepsis (12%), and gastrointestinal bleeding (6%). Following initial revision, 23 patients (71.8%) required further surgery for major complications and four patients died (12.5%). While initial revisions are frequently indicated for metabolic problems, final reoperations are more frequently undertaken for urgent, life-threatening complications. Revisional procedures for morbid obesity should be carefully considered, and the potential for major complications and/or death should be weighted heavily against proposed benefits.

Adult↗
PubMed1990

Ca2+ channel blockade inhibits gallbladder ion transport.

Recent studies suggest that cholesterol gallstone (GS) formation is characterized by altered gallbladder epithelial ion transport and increased gallbladder (GB) luminal Ca2+. Moreover, intracellular Ca2+ has been reported to be an important modulator of intestinal ion transport. The aim of the present study was to determine the effects of Ca2+ channel inhibition on GB ion transport. Prairie dog GBs were mounted in a Ussing chamber and bathed in warm oxygenated Ringer's solution, and short-circuit current (Isc), transepithelial potential difference (Vms), and tissue resistance (Rt) were recorded. Following stabilization, the mucosal surfaces of the GBs were exposed to 1 or 0.1 mM verapamil (VER). Effects on Isc were apparent within 10 sec with nadir values reached in 5 +/- 1 min. Profound (76%) inhibition of Isc was seen with 1 mM verapamil exposure (26 +/- 6 microA.cm-2) as compared to baseline values (170 +/- 6 microA.cm-2) (P less than 0.001). Verapamil exposure (1 mM) also led to a marked inhibition of Vms (P less than 0.001, vs baseline) and a significant increase in Rt (P less than 0.05 vs baseline). Similar trends were seen using 0.1 mM verapamil (Isc nadir 133 +/- 13 microA.cm-2). Verapamil-induced effects on gallbladder electrophysiology were largely reversible (75-90% recovery of baseline Isc after tissue washing). These data suggest that (1) verapamil induces rapid but reversible inhibition of ion transport and (2) Ca2+ channel blockade inhibits ion transport in a dose-dependent fashion. We would propose that intracellular Ca2+ may be a regulator of GB ion transport.

Animals↗
PubMed1990

Pathogenesis of gallstones.

The many developments in nonoperative methods for the treatment of gallstone disease underscore the importance of understanding the pathogenesis of these stones. Elucidation of the factors responsible for nucleation of crystals and the mechanism by which it occurs would appear to be the challenge if we are to define the cascade of events that results in gallstone formation.

Cholelithiasis↗
PubMed1987

AIDS: developing a primary health care task force.

As the number of people with AIDS increases, the number of people impacted by the AIDS crisis will also increase. Larger metropolitan areas have already responded to the crisis with various services (Deuchar, 1984); but the disease has yet to fully impact on smaller cities and towns. The formation of community service groups to cope with the AIDS crisis is a virtual necessity in health care preparation for persons with AIDS. The experience of the Fort Wayne AIDS Task Force reflects the potential of any community to utilize the existing resources in the gay and lesbian community, health and social service professions, and among family and friends of persons with AIDS. Consultation and resources are available through local and state boards of health, as well as local social service and health personnel currently dealing with the AIDS crisis.

Acquired Immunodeficiency Syndrome↗
PubMed1982

Updating reduction and flap procedures for baldness.

Corrective surgery for baldness now includes scalp reduction, hair-bearing flaps, and punch autografts. When baldness is mild to extreme in the vertex or anterior vertex, scalp reduction is usually indicated. By reducing the bald area of patient with extreme alopecia, a dense back-ground of hair is provided for implants in both the anterior vertex and frontal regions. Hair-bearing flaps are recommended for those with a marginal outline pattern of excessive baldness and for those with very fine, sparse hair who wish to attain strong and dense frontal growth. Using these advancements results in immediate or "instant" hair. All available adjuncts should be considered for adequate coverage and a natural appearance in the extremely bald patient.

Alopecia↗
PubMed1981

Contemporary techniques of hair replacement.

For the bald patient who is not satisfied with a hairpiece, various surgical techniques of hair replacement provide good results with minimal side effects. The punch autograft technique, in which hair is taken from the lateral portions of the scalp, is most widely used. If this technique is not adequate in a case of extensive baldness, it can be augmented by surgical resection of tissue from the bald site or by fashioning of flaps from hair-bearing areas. In all of these techniques, design of the frontal area to provide a natural appearance is of primary importance.

Alopecia↗
PubMedDate not supplied

Responding to the needs of the terminally ill through laughter and play.

Care for the terminally ill has greatly expanded. Humor and play, however, remain largely unexplored, surrendered to the cultural expectation of dignity and respect for the dying. This paper suggests several uses of humor and play with the dying, and the benefits of these interventions with patients, families, and care givers.

Family↗
PubMedDate not supplied

Adolescent sexuality: gay and lesbian issues.

Dynamics and interventions with adolescents who express concern regarding gay/lesbian issues are described, with a focus both intrapsychic and social. Both psychological and emotional aspects of sexual preference, and cultural and social expectations for those who identify themselves as gay or lesbian are considered.

Adolescent↗