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Biomedical subjects

J A Bogan

Publications and source records attributed to J A Bogan.

At least 73 records · Page 4Linked to original sources
PubMed1980

Pharmacokinetics of albendazole in sheep.

The concentrations of albendazole and its two major metabolites, the sulfoxide and sulfone, were measured in plasma and in ruminal and abomasal fluid of three sheep (surgically prepared with permanent ruminal and abomasal cannulae) orally given albendazole as a suspension at a dose rate of 10 mg/kg. Albendazole was not detectable in plasma at any time in one sheep (detection limit, 0.02 micrograms/ml) and in the other sheep, only transiently detectable. Albendazole sulfoxide was detectable in plasma and in abomasal fluid at mean peak concentrations of 3.2 and 26.2 micrograms/ml, respectively, 20 hours after administration. It is probable that much of the anthelmintic activity of albendazole in sheep is due to the metabolically formed sulfoxide and sulfone.

Abomasum↗
PubMed1979

Phenylbutazone toxicity in ponies.

The oral administration of phenylbutazone at a dose rate of approximately 10 mg per kg per day for seven to 14 days resulted in the development of signs of toxicity in seven of eight ponies treated. Clinical signs included anorexia, depression and abdominal oedema. Blood biochemical determinations showed a decrease in total plasma protein and calcium concentrations with an increase in urea concentration. These changes were considered indicative of water retention. Three of the ponies died during treatment following the development of shock. Shock was considered to arise from the submucosal oedema of the large intestine observed on necropsy. Oral ulceration was also found in these animals. In two ponies intravenous administration of phenylbutazone (4.0 mg per kg) for seven days was studied. In one of these ponies a marked decrease in total plasma protein concentration occurred.

Administration, Oral↗
PubMed1978

Lidocaine concentrations associated with intravenous regional anesthesia of the distal limb of cattle.

Cannulation for injection of lidocaine HCl was done in 3 distal veins in the hindlimb of 5 young Friesian cattle maintained in a light plane of general anesthesia. The local and systemic plasma and tibiotarsal joint synovial fluid concentrations of lidocaine (British lignocaine) were estimated for 60 minutes after the drug (10 ml, 2% (w/v)) was injected into the veins distal to a tourniquet. The lidocaine concentration in the distal veins was high but variable initially, and fell markedly over the 60 minutes. The systemic circulation always had a low but measurable concentration of lidocaine that became slightly higher in the 5 minutes after tourniquet release. According to the concentrations found, the risk of toxicity of lidocaine by using this technique in clinical practice would appear negligible.

Anesthesia, Conduction↗
PubMed1977

Phenytoin toxicity: a fatal case in a dog with hepatitis and jaundice.

Pheyntoin (Epanutin: Parke, Davis) is widely used for the control of chronic convulsive disorders in the dog because it exerts an anti-epileptic effect without causing general depression of the central nervous system. To our knowledge fatal cases of phenytoin sensitivity in the dog have not been reported. A case is described in which hepatitis, jaundice and death followed the administration of the drug.

Animals↗
PubMed1977

Effects of 3-methylindole in cattle.

1 Rapid intravenous injection of 3-methylindole (3-MI) was shown to induce an anaphylactoid-like reaction in calves. 2 This was suggested by the reduction in response to a repeat dose of 3-MI, by the reduction of effects in the presence of antagonists to the putative mediators of anaphylaxis in cattle and by the production of signs similar to those seen in experimentally induced bovine anaphylaxis. 3 The plasma half-life of 3-MI was short (14.4 min) and, since absorption of 3-MI from the rumen is known to be slow, the extent of formation of 3-MI from L-tryptophan in the rumen would have to be substantial if 3-MI is to be considered the causative agent of 'fog fever', an acute respiratory distress syndrome seen in cattle.

Animals↗