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Biomedical subjects

Iu V Parkhomenko

Publications and source records attributed to Iu V Parkhomenko.

7 recordsLinked to original sources

[Possible mechanisms of development of biliary diseases under the conditions of the Transbaikal region].

Eighty one patients with various biliary diseases and 36 apparently healthy individuals were examined. There were relatively elevated lipid peroxidation (LPO) products (E 232/220 and E 278/220) in biliary diskynesia and higher concentrations of LPO intermediate products in cholecystitis. In cholelithiasis, the levels of LPO products were lower than those in cholecystitis. E 232/220 and 278/220 may be used for early diagnosis of biliary dysfunctions. Selenium deficiency observed in the Transbaikal region decreases antiradical protection and increases the incidence of biliary diseases.

Bile Duct Diseases↗

[Role of the right ventricle in compensating for cardiac activity in myocardial infarct].

Changes in the phase structure of the systole and diastole of both ventricles of the heart with relation to the presence or absence of cardiac failure were studied in 68 patients with myocardial infarction. Four variants of such changes were defined. It was established that the right ventricle could be a factor of the compensation of cardiac activity in myocardial infarction. Change in the phase structure could be of prognostic value with regard to the development of cardiac failure. The appearance of the right ventricular high diastolic pressure syndrome against a background of a decrease in left ventricular contractility was shown to be an early sign of congestion in the pulmonary circulation and a prognostic criterion of the appearance of clinically marked left ventricular insufficiency in the nearest future requiring adequate therapy. Marked asynchronism in ventricular activity contributes to the development of cardiac failure in myocardial infarction.

Adaptation, Physiological↗

[Morphological fibroblastic changes in cytomegalovirus infection].

Cytomegalovirus (CMV) infection is widely spread among population. While immunocompetent patients suffer rarely from this virus, it can lead to a lethal outcome in immunocompromised patients. An electron microscopic study has detected fibroblastic morphological changes of a definite cytodestructive character. The nuclei of some fibroblasts have chromatine condensation. A clear zone arising due to vacuolization near this inclusion may reflect nuclear rearrangement leading to further CMV metamorphosis of the cell. This metamorphosis is characteristic of the changes developing in the cells of different parenchymatous organs.

Chromatin↗