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Biomedical subjects

Iu V Bukanova

Publications and source records attributed to Iu V Bukanova.

8 recordsLinked to original sources
PubMed1998

[Cyclic GMP mimicks potentiation effect of the nootropic agent vinpocetine on the high threshold A-current in the mollusk neurons].

High-threshold transient K+ current (IAht) was recorded using a two-microelectrode voltage clamp technique in isolated neurons of the land snail. Effect of the nootropic drug vinpocetine on this current was studied and compared with cyclic nucleotides. The drug either enhanced or left unaltered the IAht, and dibutyryl cyclic GMP (dcGMP) imitated the effect. These two effects were not additive. Dibutyryl cyclic AMP did not imitate, the vinpocetine effect and decreased the amplitude of the IAht. The findings suggest that the cGMP mediated the vinpocetine effect on the Iaht.

Animals↗
PubMedDate not supplied

[The nootropic agent vinpocetine blocks the delayed rectifier potassium channel more strongly than the high-conductance calcium channel].

In isolated neurons of Helix snail high-threshold Ca(2+)- and K(+)-currents were recorded using two-microelectrode voltage clamp technique. Extracellular application of nootropic drug vinpocetine rapidly and reversibly blocked both types of current. Vinpocetine effects were dose-dependent and voltage-independent. The maximal effect of Ca(2+)-current blockade was 27% during application of vinpocetine in the concentration of 600 mcM. The maximal blockade of K(+)-current was 75% when the drug was applied in the concentration of 30 mcM. Results suggest that K(+)-channels are more probable targets for vinpocetine than Ca(2+)-channels.

Animals↗