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Biomedical subjects

Iu I Pigolkin

Publications and source records attributed to Iu I Pigolkin.

At least 19 recordsLinked to original sources
PubMed2004

[Age-dependent dynamics of the rib and tibial microstructures].

The purpose of the present work was the detailed study of peculiarities of the bone tissue age changes. The samples of the bone tissue of the third left rib (taken from the zone of osseo-cartilagenous transition), as well as the distal epiphysis and diaphysis of the left tibia were used as a material for this research. The samples were obtained from 364 male cadavers of the persons aged 0 to 90 years. As a result of this study, the dynamics of bone features that were most age-dependent was described, and their quantitative characteristics were determined. The conception is formulated, according to which bone age involution should be regarded as an ultimate result of accumulation of residual phenomena of its physiological regeneration cycles, former injuries and progressing pathological processes leading to the gradual reduction of the structural orderliness of the tissue.

Adolescent↗
PubMed2003

[Age dynamics of bone tissue and its significance in forensic-medical practice in age determination].

A method was worked out designed to determine the biological age of man by using the data of quantitative histological, X-ray and X-ray-densitometry examinations of bone tissue including the technique of measuring the quantitative signs as well as a variety of mathematical model and an algorithm of their application. A new set of qualitative features was suggested, which makes it possible to attribute an individual to a certain age group; besides, an improved complex of parameters of the quantitative analysis of preparations was described, including the measurement of linear sizes and of sectional areas of microstructures in the visual field. The method is meant for determining the age at death within the forensic medical identification of personality, should it be impossible to do it by using the macroscopic features. A scheme of ontogenesis periodization is suggested for the forensic medical practice. A concept was formulated, according to which the age involution is a summarized result of the accumulation of the physiological activity cycles, endured damages and of progressing pathological processes.

Age Determination by Skeleton↗
PubMed2002

[Toxicomania in servicemen].

The authors substantiate the urgency of toxicomania among the servicemen. The circumstances of toxicomania, its morphological manifestations, toxic agents used by the toxic substance addicts were analyzed using the materials of 98 observations from medicolegal practice with lethal outcome. The measures to prevent and diagnose the toxicomania are proposed.

Adolescent↗
PubMed1999

[The medicolegal aspects of the prevention and diagnosis of drug addiction].

The article focuses on a number of medical and legal problems in the drug addiction and toxicomania elimination in the Armed Forces. It contains some new information on recent documents and publications of the Ministry of Health and the government on the subject. At the other hand, the authors make an overall assessment of the analysis' possibilities in the country and its Armed Forces.

Drug and Narcotic Control↗
PubMed1990

[Changes in the neural apparatus of the cerebral arteries in atherosclerosis].

Nervous apparatus of the brain arteries (450-60 microns in diameter) in 55-64-year-old patients with cerebral atherosclerosis was studied. Alterations in the afferent innervation were manifested in the increased sinuosity of fibers, areas of hyper- and hypoimpregnation, appearance of thickenings in the fibers. Changes in the vasomotor innervation consisted of the disturbances of the nerve network structure, an increase of nerve fibers concentration and varicosity in the cholinergic plexuses and their decrease in the adrenergic ones. Restructurings of the nerve apparatus were more pronounced in the arteries of large caliber.

Acetylcholinesterase↗
PubMed1990

[Innervation of human pia mater arteries of different diameters in arteriosclerosis].

Scanning electron microscopy, impregnation, histochemical methods with acetylcholine esterase (AChE), choline acetyltransferase and glyoxylic acid were used for studying elements of afferent and efferent (+ adrenergic and cholinergic) innervation of pial arteries 450-60 microns in diameter in persons with "preclinical" atherosclerosis. Marked changes of the nervous system were found in arteries of large calibre. Disorders were seen in afferent innervation with increased crimp in nervous fibers, alternate patches of hypo- and hyperimpregnation, thickening with a high AChE activity, reactive changes in receptors. The structure of choline- and adrenergic nervous plexuses was disordered; the concentration of nervous fibers and varicosities in particular in fluorescent plexuses was decreased, with a moderate increase in the concentration of these structures being seen in cholinergic plexuses.

Adrenergic Fibers↗
PubMed1989

[Immunochemical identification of vasopressin in neurons and in granule-containing cells of the human cerebral blood vessels].

By means of indirect immunofluorescent method vasopressin localization has been defined in neurons of the locus coeruleus, in terminals, converging to the substantia nigra cells and the sylvian aqueduct area, as well as in the granule-containing cells of the human cerebral blood vessels. The granule-containing cells are identified as melanocytes, when investigated by comparative light-optic and electron microscopical technique. The melanocytes of the cerebral vessels have various size and form in accordance to their different functional state. In some melanocytes peptide vesicles are revealed. This demonstrates a possible synthesis of vasopressin. It is supposed that local endocrine regulation of the cerebral hemocirculation is performed by cooperation of granule-containing cells, producing hormones with oppositely++ directed constrictor and dilatator action to the vessels.

Brain↗
PubMed1989

[Comparative study of the cholinergic and adrenergic innervation of the cerebral vessels in humans and various laboratory animals].

Choline- and adrenergic innervation of intracerebral branches of the middle and posterior cerebral arteries has been investigated histochemically and electron microscopically in slices, or after their preparation after W. Penfield. The vessels have been studied in the area of the fields 41, 17 of the cerebrum, trunk and spinal cord of the human being, cat and dog. When studying innervation of the intracerebral arteries (ICA), the preparation method has some advantages in comparison with investigation of these vessels in slices of the brain. Around most of the ICA from 200 up to 30 mcm in the diameter choline- and adrenergic nervous conductors are revealed. Using the method for calculating varicosities in nervous plexuses, it is demonstrated that degree of the ICA innervation is two times less than that in the arteries of similar caliber in the cerebral pia mater.

Adrenergic Fibers↗
PubMed1988

[Comparative characteristics of adrenergic innervation of the cerebrospinal arteries of vertebrates and man].

Adrenergic innervation of the cerebrospinal arteries in redeye, frog, tortoise, hen, sea-gull, guinea-pig, rabbit, cat, dog and man has been studied by means of fluorescent-histochemical method. In all the animals there is a similar principle of innervation. The nervous apparatus is revealed as continuous integral plexuses. In the process of historical development the role of the nervous factor in regulation of the cerebrospinal circulation is increasing. As the innervational degree of the spinal arteries decreases, the vertebrates make the following line: mammals, birds, reptiles, amphibia, fishes. In all the animals, besides the fishes, the greatest concentration of the nervous fibers is revealed in the areas of the spinal cord thickenings.

Animals↗
PubMed1987

[Adrenergic innervation of the arteries of different diameters in the human and animal pia mater].

The adrenergic nervous plexuses of the pial arteries from 450- to 50 micron in diameter have been studied in dogs, cats and humans from 4 age groups (22-44 years, 55-64 years, 65-74 years and 75-86 years old). It has been found that the decrease in the vessel diameter was accompanied by a marked decline in the absolute number of nervous fibers in the nervous plexuses, however the concentration of the nerve fibers has not revealed any significant differences between human arteries from 450 to 100 micron in diameter and animal arteries from 300 to 80 micron in diameter. The number of varicosities-thickness along the nerve fiber--was the greatest in 200-100 micron human arteries and in 80-60 micron animal arteries. With ageing, the number of varicosities in the adrenergic nervous plexus of human pial vessels decreased faster than in the nerve fibers.

Adrenergic Fibers↗
PubMed1983

[Cholinergic and adrenergic innervation of human intracerebral arteries in ontogenesis].

The intracerebral branches of the anterior, medial and posterior cerebral arteries in the cerebral tissue sections or revealed by means of the preparation method have been studied in cortical parts of the acoustic, optic and motor analyzers at various age periods (from the second half of pregnancy up to 86 years of age). On the intracranial arteries of all the age groups, the adrenergic and cholinergic fibers are revealed in the radial arteries and their large branches. Differences in the maturation rate and in involution of neural conductors have been stated between the cholinergic (revealed by means of reactions for acetylcholinesterase) and adrenergic (reaction with glyoxylic acid) conductors.

Acetylcholinesterase↗
PubMed1983

[Dynamics of postmortem changes in the adrenergic nerve fibers of the cerebral arteries].

The authors studied the changes in the quantity and intensity of adrenergic nerve fiber fluorescence in the rat and human brain arteries every two hours after death at varying temperatures of keeping cadavers (18-20, 10, 4 degrees C). It was established that the differences in the temperatures had an appreciable effect on the duration of complete exposure of nerve fibers as compared with control. No significant reduction in the number of fluorescent conductors was seen for the longest period of time (up to 10 h in rats and up to 8 h in man) at a temperature of 4 degrees C. The relationships are defined between postmortem changes in nerve fiber fluorescence and their number under varying temperatures.

Adolescent↗
PubMed1982

[Morphological studies of the regulatory mechanisms of intracerebral blood circulation].

The intracerebral branches of the posterior and medial cerebral arteries in the area of the grey and white substances of the parietal, occipital and temporal cerebral lobes, of the nuclei in the superior and inferior colliculi in the tectum mesencephali. as well as in the pons have been studied in 36 male corpses at the age of 5--49 years by means of Cajal, Koelle, Furness and Costa methods. Presence of sensitive neural terminals, cholinergic plexuses has been stated in the intracerebral artery walls with the diameter up to 100 mcm and more, as well as adrenergic neural network on the arteries with the diameter up to 100 mcm and more, as well as adrenergic neural network on the arteries with the diameter up to 40 mcm and more. Besides, near the cerebral substance vessels monoaminocytes situating both in the area of the sphincter torus and in the arterial walls have been revealed. A suggestion is made that the proper neural and other apparatuses of the intracerebral circulatory bed play a certain role in regulation of the local cerebral circulation.

Acetylcholinesterase↗
PubMed1982

[Age characteristics of the efferent innervation of the arteries of the human pia mater].

By means of histochemical reactions revealing acetylcholinesterase, cholinacetyl-transferase activity and using glyoxylic acid, formation and involution of cholinergic and adrenergic neural fibres have been studied in the pia mater arteries of the human brain (in the temporal, parietal and occipital areas) beginning from 12-14 weeks of the intrauterine development up to 86 years of age. The development and formation of the vascular neural apparatus goes in parallel with differentiation of the cerebral areas which they feed. Maturation of the cholinergic neural plexuses takes place earlier, and age involution--later than those of the adrenergic neural plexuses. In mature age, concentration of the neural fibres in the walls of the pia mater arteries having the same calibre but taken from different areas of the brain varies significantly.

Adolescent↗
PubMed1981

[Adrenergic innervation of the pial arteries of the human brain].

By means of glyoxylic acid adrenergic neural fibres have been studied in fetuses at the second part of pregnancy, in a 2-month-old boy, in a 18-year-old boy, in three men 30-, 34- and 40-year-old. According to the data of fluorescent microscopy, the fibres studied contain noradrenaline. In walls of the arteries 400 mkm and more in diameter there are double-layered adrenergic plexuses. In arteries of smaller diameter the adrenergic plexuses predominantly consist of longitudinal fibres. The adrenergic apparatus is situated within the external membrane; its development is more perfect in mature persons than in fetuses and in children before one year of age.

Adolescent↗
PubMedDate not supplied

[The morphological characteristics of chronic subdural hematomas].

Preparations of chronic subdural hematomas (CSH) obtained during surgery from 29 patients aged 19-50 years are studied. Histological sections were stained with hematoxylin-eosin after van Gieson. Morphological criteria of CSH variants are defined, permitting forensic medical experts to make well-based conclusions on the nature (traumatic or not) of CSH (two types of capsules) and the time when it occurred.

Adult↗