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Biomedical subjects

Iu I Borodin

Publications and source records attributed to Iu I Borodin.

At least 19 recordsLinked to original sources
PubMed2005

[Regional lymphatic drainage and lymphodetoxication].

Drainage and detoxication functions of lymphatic system at regional level are discussed. Lymphodetoxication is regarded as a unity of biophysical, biochemical and immune actions upon the lymph in lymphoid structures of an anatomical region. Regional lymphatic drainage is considered as a three-component mechanism, that includes interstitial pathways of non-vascular microcirculation, regional lymphatic vessels and lymph nodes. As a whole, this construction represents a lymphatic region, that includes, besides the pathways of vascular and non-vascular lymph circulation, other lymphoid structures, which are present in this region (individual cells, constant and temporary aggregations of lymphoid tissue).

Animals↗
PubMed2005

[Lymphatic system and water homeostasis].

Using the methods of light and electron microscopy as well as histochemistry, the complex study of structural-cellular state of the wall of small intestine and its grouped lymphoid nodules, mesenterial and iliac lymph nodes and thymus was performed in rats subjected to the changes of a type of drinking water. Tap, distilled and radon waters were used. The organism was found to respond to the changes in the type of drinking water by both non-specific (increase in sectional area of lymphatic vessels and the number of eosinophilic granulocytes in the wall of small intestine, in lymphoid nodule number containing germinal centers in lymph nodes, in proportion of thymus connective tissue component, increased lymphocyte dehydrogenase activity) and specific reactions, which were characteristic only to a given type of water. The latter, for example, included the activation of the function of protein synthesis in endothelial cells of lymphatic capillaries of the small intestine and increased numbers of plasma cells and dividing cells in lymphoid organs in rats consuming distilled water; increased proportion of blood capillaries in the wall of the small intestine, accompanied by the ultrastructural signs of reduction of plastic processes in them in animals drinking radon water. The response of the wall of the small intestine and lymphoid organs of an animal to the effect of drinking waters, different in their mineral content and radon concentrations, was subjected to general biological regularities and took place in two phases of an adaptation process, functional stress and resistivity.

Animals↗
PubMed2000

[The ultrastructural changes in the cellular lining of lymph node sinuses in organochlorine pesticide poisoning].

In conditions of exotoxicosis arising after the effect of 2,4-dichlorphenoxyacetic acid cytoplasmic cells of littoral cells of marginal and medullary sinuses undergo alike changes and their cell organelles (rough endoplasmic reticulum, Golgi complex, micropinocytotic vesicles and mitochondria) mass is reduced. These changes are more pronounced in littoral cells of marginal sinus when the dos under the effect of 4 permissible doses of the poison. Intensity of intracellular structures reaction to the toxicant action depends on the cell localization on the lymph passage insid within the lymph node (marginal or medullar sinuses). Dystrophic changes in sinus lining cells so as the speed and character of regenerative processes depend on the dose and time of action of the agent.

2,4-Dichlorophenoxyacetic Acid↗
PubMed2000

[Morphological changes of lymphatic system in patients with the lymphedema of lower extremities].

Morphological changes in inguinal lymph nodes, lymphatic collector and subcutaneous space were studied up in patients with the lower extremities lymphoedema. While the lower extremities lymphoedema occurs in inguinal lymph nodes the connective tissues spreading in two variants is observed. In the first one fibroblasts and collagen fibres appears in medullar substance (chordae medullaris and medullar sinuses) and in the second the sclerosis process begins from cortical plateau and paracortical zone. It is expedient to include the intraarterial infusion of the xenospleen preparations in complex of treatment of patients with initial stage of the lower extremities lymphoedema, especially in the absence of possibility to proceed with microsurgical intervention and the erysipelas presence in anamnesis.

Adolescent↗
PubMed1999

[The state of the lymphatic system in inflammation of the internal sexual organs].

In conditions of experimental inflammation of internal sexual organs in female rats fast and adequate reorganization of its lymphatic bed was found. In the nidus of inflammation sufficient drainage of tissues was retained. Loose and widened sinuses of ileal lymph nodes provided sufficient intranodal lymphodynamics. Formation of additional barrier composed of lymphoid cells was detected in paravaginal fat. Reduction of the speed of lymph flow within lymphangions promoted adequate conveyance of toxic lymph to nodes and its further processing. Mobilization of all links of lymphatic barrier resulted in its maximum activation and self recovery by d 14.

Animals↗
PubMed1999

[The artificial lymph node].

Adsorption of lymphocytes on the sorbents in correction of inflammatory lesions has significant clinical perspectives as the cells and active biological substances they secrete function actively in inflamed tissues acting in the site of its application: every cell adsorbs and inactivates foreign substances, every cytokin affects certain target cells. The products of these cells functioning and dissociation as well as the products of immune system reaction to them remain on the sorbent and are eliminated together with granules during bandaging or by the end of the treatment thus do not entering the organism. Lymphocytic monolayer on the sorbent does not prevent its specific action in pathologic nidus. In this case sorbent does not only drain the tissue duplicating certain primitive non specific functions of regional lymph node (barrier, filtrating, transport, draining and protective functions) but also performs certain highly specialized functions of immunocompetent organs--selective adsorption and inactivation of antigenic substances. It is reasonable to use sorbents for adsorbing lymphocytes in kapron containers which exclude the preparation leak into wounds and cavities and act as a filter preventing fast inactivation of the preparation by large fragments of tissue detritus.

Animals↗
PubMed1996

[The valves of the marginal sinus of the lymph nodes].

Popliteal lymph nodes of male Wistar rats were studied in scanning regime of electron microscope. On the base of the data obtained it is concluded that on the lymph node surface and in the thickness of a capsule afferent lymphatic vessels branch into thin rami supplied with valves from the inside of the capsule in the site of falling into marginal sinus. Valvular apparatus found obviously gives possibility to regulate lymph flow in the lymph node.

Animals↗
PubMed1995

[Lymphogenic introduction into lesser circulation of orally administered rifampicin in standard and liposomal forms].

Pharmacokinetics of water and liposomal suspensions of lipophilic antibiotic rifampicin introduced intragastrically through a tube was studied in experiments on Wistar rats. After administration of water suspension rifampicin concentration reached its peak in all the tissues in 3 hours, lung concentration being 1.6 and 1.9 times higher than blood one. After liposomal suspension administration lymphatic rifampicin concentrations were maximal in 3 hours, while in the lungs and blood they were the highest in 6 hours. It is concluded that oral liposoluble drug enter primarily chyle vessels and via thoracic lymphatic duct directly lesser circulation. Liposomal inclusion of the drug warrants its high concentration in lymphatic system and lung tissue.

Administration, Oral↗
PubMed1995

[The structural organization of the regional lymph nodes of the heart in the acute period of experimental myocardial ischemia].

Anterior mediastinal and popliteal lymph nodes were studied morphologically and cytologically in male Wistar line rats in an acute period of experimental ischemia resulting from ligation of the left coronary artery. Three stages of structural-functional changes were demonstrated. In first stage increase of cortical substance square, widening of intermediate sinuses and macrophage number increase in all lymph node zones were observed in both groups after ligation of the artery. Second stage (day III of the ischemia) is characterized with the accumulation of plasmatic series cells and reaction of blast transformation in lymph node zones. In third stage (day 7 of the ischemia) restoration of medullar sinuses square up to the control values and even certain increase of the latter were observed. Morphofunctional changes in an acute period of the experimental ischemia of myocardium depend on the lymph node functional specialization and they are greater expressed in mediastinal lymph nodes of the heart region. It was suggested that in an acute period of ischemia of myocardium lymph nodes influence the quantity and cellular content of the passing lymph.

Acute Disease↗
PubMed1994

[Healing effects of several ecological exposure factors on the lymphatic system].

The structural and functional responses of lymph nodes to environmental influences have common stereotypic features; however, they can vary with the nature of an influencing factor and the functional specialization of the lymph node. In this view, the morphological and functional status of lymph nodes can be regarded as markers of environmental impact on the lymphatic system. Approaches to correcting blood and lymph circulation have been developed via combined exposure of the body's internal environment to sorbent therapy, balneological procedures at the Siberian resorts, biological flavonoids, and derivatives of Siberian raw plant materials.

Animals↗
PubMed1993

[A method for measuring electric impedance in evaluation of the course of experimental myocardial infarction].

Electrical impedance of white rats heart muscle of wistar population was measured in different terms of experimental myocardial infarction. Results of electroimpedansometry reflect in full extent structural changes, taking place in a heart muscle. General tendency of animal and human healing processes was found and it was confirmed, that infarction affects the whole heart muscle.

Animals↗
PubMed1992

[The status of the lymphoid organs in the maternal organism as a reflection of the efficacy of correcting venous congestion during pregnancy in rats].

Under study was the influence of polyphenolic complexes of great burnet and venoruton upon the thymus, spleen, iliac lymph nodes of the uterus area in experimental phlebo-occlusion syndrome of pregnant rats. The data obtained show the changes of the drainage function of the lymphatic system under the influence of the drugs under study, certain reaction of T- and B- dependent zones of the central (thymus) and peripheral lymphoid organs. The structural-functional shifts had positive effects upon the fetus state. The action of polyphenols of great burnet is more effective as compared with venoruton.

Animals↗
PubMed1992

[Neuromediator provision of the organs of immune system in benzpyrene intoxication].

The density of adrenergic innervation and relative content of catecholamines were investigated in rat lymphoid organs under different type of benzpyrene treatment. It was found that both ante- and postnatal influence of toxicant leads to a decrease of neurotransmitter providing of the thymus, spleen, mesenterial, iliac and popliteal lymph nodes. On the contrary, when mixed ante- and postnatal benzpyrene influence has place, the adrenergic innervation density and relative content of catecholamines are increased. We suppose that benzpyrene treatment of pregnant animals has specific "training" effect for monoaminergic systems of foetus and causes the increase of neurotransmitter providing of immunocompetent organs in conditions of repeat body and toxicant meeting.

Animals↗