[Correction of metabolic shifts in preserved donor blood by using the "artificial kidney" apparatus].
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Biomedical subjects
Publications and source records attributed to Iu F Tomakh.
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The paper considers a clinical role of crystalluria and its relation to urolithiasis. Examination of 185274 cases of symptomless crystalluria in the citizens of Kharkov and Kharkov region revealed oxalic-calcic urinary crystals in 12.2%, urate crystals in 3.6% and phosphate crystals in 1.2% of the examinees. Oxalic-calcic crystalluria in urgent urinary conditions occurs significantly more frequently (25.8%). Crystalluria was studied in 372 nephrolithiasis patients. Urinary crystals were found in 44.0%. The type of the crystals corresponded to chemical composition of the urinary concrements. Oxalic-calcic nephrolithiasis was detected in a younger group of patients (aged 37.3 +/- 1.3). It is suggested to consider crystalluria as microurolithiasis indicating predisposition to lithogenesis in the urinary tract and as a preclinical manifestation of urolithiasis.
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Urolithiasis diagnosis by uroliths presence reflects insufficient knowledge of the disease pathogenesis. 42 patients with oxalocalcium nephrolithiasis and 20 healthy patients were examined for differences in the urine and plasma composition. The authors studied factors involved in regulation of mineral metabolism and urinary elimination of crystal-forming substances. The patients with urinary stones compared to the control are characterized by low total crystal-inhibiting activity, hyperosmia, hypodipsia, decreased surface free energy, high quantities of ionized calcium, low ionized magnesium in the urine, oligo- and uricosuria. Shifts in hormonal regulation in nephrolithiasis result from slight elevation of urinary cyclic adenosine monophosphate, a relative rise in the levels of aldosterone and parathyroid hormone, low blood calcitonin, all the changes being statistically significant.