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Biomedical subjects

Iu A Pytel'

Publications and source records attributed to Iu A Pytel'.

At least 19 recordsLinked to original sources
PubMed1997

[Intravenous tumor invasion in renal cancer].

Intravenous tumor invasion occurred in 84 out of 600 patients who had been operated on for carcinoma of the kidney. The inferior vena cava was thrombosed by a tumor in 54 patients. Ultrasonic examination, computed tomography, and venocavography were used in establishing the diagnosis of intravenous invasion. It is stressed that information on the upper border of the thrombus in the inferior vena cava must be obtained before the operation, and that in block on the inferior cavogram transatrial venocavography is absolutely indicated. The presence of absence of growth of intracaval tumor masses into the wall of the inferior vena cava is an important moment determining peculiarities of the operation. In the authors experience such invasion was encountered in 30% of patients. Fifty-two patients had subdiaphragmatic thrombosis of the inferior vena cava and 2 patients had supradiaphragmatic thrombosis. In addition to radical nephrectomy, 28 patients underwent resection of the lateral surface of vena cava inferior, 17--thrombectomy from vena cava inferior, and 8--resection of a segment of this vein. Postoperative lethality was 9.5%, 5-year survival was 40.8%. It was found that venous invasion without growth of the tumor into the fibrous capsule of the kidney and without lymphogenous and distant metastases has no negative effect on the prognosis if the tumor masses had been removed completely from vena cava inferior. The authors believe operations on patients with renal carcinoma and venous tumor invasion in stages T2N0M0, T3N0M0 and T2-3N1-2M0 to be advisable.

Humans↗
PubMed1996

[Comprehensive treatment with ofloxacin in pyo-inflammatory urologic diseases].

Fifteen patients with various forms of pyelonephritis and chronic cystitis were treated with ofloxacin. The drug was used in the complex antiinflammatory and detoxification therapy and in cases with indicated hemotransfusion. Ofloxacin was administered intravenously during the first days of the treatment with its later oral use. High efficacy of ofloxacin was observed in the patients with acute purulent renal affections accompanied by pyo-intoxication when the treatment was started with the drug parenteral administration.

Acute Disease↗
PubMed1991

[Use of pyelomanometry and roentgenological and television uroscopy in determining the time for nephrostomy closing].

To evaluate objectively the degree of the urodynamics recovery in patients with nephrostomy in the postoperative period and to determine the optimal times of removing the nephrostomy drainage tubes, a ++video-urodynamic study was carried out. It consisted in combined antegrade X-ray TV ++pyelo-ureteroscopy and ++trans-fistula pyelomanometry. To measure the degree of the effect of retroperitoneal pressure on urodynamics, intraperitoneal pressure was also evaluated. The volumetric rate of the perfusion of the radiographic contrast substance ranged from 1 to 7 ml/min. As many as 108 patients with nephrostomy were examined within different times after the operation. Urodynamics was regarded as recovered, if the difference between pelvic and intraperitoneal pressure did not exceed 12 cm H2O, with the volumetric rate of perfusion being different. In 76/108 patients (70.4%), adequate passage of urine in the ++upper urinary tract was determined, which allowed one to attempt nephrostomy closing. In 32/108 patients (29.6%), the results of the study were viewed as unsatisfactory which required continuation of the draining of the pelvi-calyceal system by the nephrostomic drainage tubes. Repeated investigation carried out after 5-10 days revealed the normalization of the urodynamic characteristics. No complications were recorded after the nephrostomic drainage tubes were removed.

Adolescent↗
PubMed1988

[Effect of prazosin on human prostatic adenoma tissue].

The effect of prazosin on epinephrine-induced contractions of human benign prostatic hyperplasia strips was studied. It was shown that prazosin has a pronounced adrenoblocking activity (EC50 = 5.10(-9) g/ml) but fails to affect strip contractions induced by KCL. It is suggested that prazosin can be used in the treatment of patients suffering from benign prostatic hyperplasia.

Dose-Response Relationship, Drug↗
PubMed1984

[Role of heparin in the realization of the hypoglycemic action of insulin].

The presence of reactive heparin in blood circulation is necessary for realization of the hypoglycemic action of insulin. This is confirmed by the fact that after heparin binding by protamin sulfate both endogenous and exogenous insulin do not exhibit any hypoglycemic activity. In animals with different basal concentration of heparin in the blood, the blockade of insulin action is attained by application of different doses of protamin sulfate, respectively. Based on the data obtained one can determine an approximate blood heparin concentration necessary for realization of the hypoglycemic action of insulin.

Animals↗