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Biomedical subjects

Iu A Ermakov

Publications and source records attributed to Iu A Ermakov.

15 recordsLinked to original sources
PubMed1996

[The problems in optimizing the delivery of general therapeutic care at the regional level during the transition to compulsory medical insurance].

The authors hold that perfection of local therapeutic service in present-day situation when insurance principles are introduced in medical care may be achieved through design of medico-economic standards of guaranteed minimum of medical aid for each citizen of Russian Federation. This approach allows accurate estimation of required personnel and equipment. The standards should not replace the principle of individual approach to each case.

Delivery of Health Care↗
PubMed1994

[An evaluation of the relationships between the ionic and osmotic secretory capacities of the kidneys and interstitial medullary edema in patients with chronic glomerulonephritis].

Ion- and osmoregulatory capacity of the kidneys under induced water diuresis have been investigated in 100 patients with chronic glomerulonephritis (CGN) with reference to CGN clinical and morphological variants. An independent morphologist conducted a blind assessment of the results obtained at semiquantitative light morphometry of the renal medullary interstitial edema. According to an original formula, the morphometric index of the renal medullary edema was transformed into the index of the effective medullary edema (EME). The greatest EME occurred in CGN patients with nephrotic syndrome (NS). These patients and those with CGN and isolated urinary syndrome displayed inverse nonlinear relationship between EME and clearance of endogenic creatinine (Ccr), p < 0.05. In patients with CGN and NS, CGN and secondary arterial hypertension, membranoproliferative glomerulonephritis (MPGN), membranous glomerulonephritis (MGN) with NS advancing EME demonstrated association with decreased sodium or chlorine clearance. In groups with MPGN, MGN with NS a nonlinear relationship existed between EME and urea clearance. The findings suggest an important role of renal medullary edema in promoting disorders of renal filtration and ion-secretion capacity in CGN.

Adolescent↗
PubMedDate not supplied

[Kinetics of the reaction of hemoglobin with carbon monoxide. I. Relaxation measurements during photolytic illumination].

The relaxation curves in HbCO solutions to steady 1 and equilibrium 2 states were investigated at different temperatures and photolytic illumination intensities I. It was observed that in case of low I they were of identical shape and had more than one relaxation time. Increase of I leads to changes in the "tails" of curves 1 and in the initial parts of curves 2; the shape of curves 2 becomes simpler. The latter is interpreted as a result of a slow relaxation of the Hb molecules conformation to an equilibrium ligand-free state just after HbCO photodissociation.

Carbon Monoxide↗
PubMedDate not supplied

[Kinetics of reactions between hemoglobin and carbon monoxide. II. Analysis of kinetic schemes in linear approximation].

The kinetics of hemoglobin (Hb) reactions with carbon monoxide were calculated for a number of classical schemes: with one, two, four binding sites and an allosteric scheme with T- and R-conformers. The developed theory predicts the existence of only one relaxation time for every scheme the values of which depends on the velocity constants, saturation degree and the Hb concentration.

Binding Sites↗
PubMedDate not supplied

[Boundary potentials of lipid membranes in the presence of 1-anilino-8-naphthalene sulfonate ions].

Boundary and zeta potentials induced by ANS adsorption in dioleoyl lecithin membranes were measured using three methods, namely: inner membrane field compensation, measurements of carrier-mediated membrane conductance and microelectrophoresis. The changes of boundary potentials due to ANS adsorption recorded by the first two methods were the same and did not depend on the ionic strength of aqueous solutions. On the contrary, the values of zeta potentials were smaller as compared with the boundary potentials, and depended on the ionic strength. The results obtained were described satisfactorily by means of combination of Henry, Gouy-Chapman and Boltzmann equations, when ANS ions were assumed to adsorb at a plane shifted towards the hydrophobic region of the membrane.

Anilino Naphthalenesulfonates↗
PubMedDate not supplied

[Theory of hydrophobic ion adsorption in bilayer lipid membranes taking into account their lateral interaction and charge discreteness].

A relationship was calculated between the number of adsorbed hydrophobic ions and the potential created by them in BLM and concentrations of these ions in solution, ionic strength in solution, the value of the membrane charge and the potential dipole shift on the BLM surface. It was assumed in the model under consideration that the ion adsorption plane was located at some depth inside the membrane, the discrete nature of the ions, their possible lateral interaction and existence of various adsorption centres in the membrane being taken into account.

Ions↗
PubMedDate not supplied

[Adsorption of 1-anilino-3-naphthalenesulfonate on bilayer lipid membranes].

A study has been made of the dependence of a membrane potential produced by adsorbed ANS anions on their bulk concentration, on the ionic strength of the solution, on the magnitude of charge and dipole potential drop at the bilayer surface. Measurements have been made on artificial planar membranes of various composition by the inner field compensation method. On membranes of neutral lipids the ionic strength dependence was absent, while on charged BLM an increase in ionic strength resulted in a parallel shift of the potential dependence on ANS bulk concentration. A theory previously developed has been used for the interpretation of our results. It is assumed there that the adsorption plane of ANS ions is located within the membrane and account is taken of the discrete charge effect and the non-electric interaction of ions in the adsorption plane.

Adsorption↗
PubMedDate not supplied

[Kinetics of the reaction between hemoglobin and carbon monoxide. III. Existence of conformationally unequal Hb molecules during the process of CO binding and dissociation].

The experimental data concerning CO binding to Hb in linear kinetic experiments were compared with theoretical results obtained earlier for several models. The results indicate that during the processes of CO binding and dissociation there appears Hb and HbCO molecules in out-or equilibrium conformational states. The dissociation effective rate constants for these HbCO molecules, formed from Hb molecules in equilibrium conformational state are kdiss greater than or equal to 5.5 s-1. At the same time, the equilibrium HbCO complexes after conformational relaxation have much smaller values of kdiss near to the well known literature values, i.e. 0.015 s-1.

Carbon Monoxide↗
PubMedDate not supplied

[The reaction of the kidneys and acid-base and osmotic homeostasis to moderate physical exertion in patients with chronic pyelonephritis in the pre-azotemia period].

Bicycle ergometry (BE) up to submaximal heart rate provoked moderate metabolic acidosis in 52 patients with chronic pyelonephritis (CP) in preuremic stage. Similar changes in acid-base balance following BE were noted in 14 patients with chronic glomerulonephritis (CGN). BE in CP promoted the reduction in diuresis and fraction water excretion, elevation of creatinine concentration in the urine and its concentration index in the absence of alterations in sodium and osmotic homeostasis. In CGN BE induced similar changes but an insignificant decrease in diuresis and a significant rise in serum sodium concentrations, osmolality of the urine, osmotic concentration index, absolute reabsorption of osmotically free water, fall in excreted sodium fraction. It is suggested that the above differences in the response to exercise test in CP and CGN may relate to tubulointerstitial nature of CP.

Acid-Base Equilibrium↗