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Biomedical subjects

Irina Turchin

Publications and source records attributed to Irina Turchin.

11 recordsLinked to original sources
PubMed2006

Unusual cutaneous findings of urticaria pigmentosa and telangiectasia macularis eruptiva perstans associated with marked myelofibrosis.

Mastocytosis is a heterogeneous group of disorders characterized by mast cell hyperplasia in the bone marrow, liver, spleen, lymph nodes, gastrointestinal tract, and skin. We present a patient with malignant mastocytosis of 11 years' duration. This case highlights the cutaneous findings of mastocytosis with systemic involvement, yet the patient maintains a relatively normal lifestyle with only minimal discomfort and only borderline normochromic anemia. Thus his course is not truly that of malignant mastocytosis but of indolent systemic mastocytosis with cutaneous findings of telangiectasia macularis eruptiva perstans (TMEP).

Aged↗
PubMed2006

Cross-reactions among parabens, para-phenylenediamine, and benzocaine: a retrospective analysis of patch testing.

BACKGROUND: Parabens are alkyl ester derivatives of para-hydroxybenzoic acid and are the most commonly used preservatives in the cosmetic industry. Cross-reactions with para-amino compounds, namely, benzocaine and para-phenylenediamine (PPD), have been reported but are thought to be extremely rare. OBJECTIVE: To evaluate the rate of cross-reactivity between parabens, PPD, and benzocaine in a population of patients patch-tested in a hospital-based contact dermatitis clinic. METHODS: A retrospective analysis of 4,368 patients consecutively patch-tested between July 1989 and June 2005. RESULTS: Our study demonstrated that the rate of cross-reactions to parabens in PPD- and benzocaine-positive patients combined is 2%. CONCLUSION: This cross-reaction rate is significant in the tested population but still falls within the previously reported rates of sensitivity to parabens in the general population (0 to 3.5%).

Anesthetics, Local↗
PubMedDate not supplied

Myths and misconceptions: the risk of melanoma in small congenital nevi.

A 2-year-old boy presents with a 4 x 3-cm, darkly pigmented nevus on his back. His mother states that this lesion has been present since birth. Both parents noticed that the nevus has become slightly larger but deny any other changes in its appearance. The boy is otherwise healthy. He has no allergies and does not take any medication. There is no family history of skin disease or cutaneous malignancy. The parents are concerned about the melanoma risk in their child's congenital nevus.

Humans↗