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Biomedical subjects

Ingeborg Schafhalter-Zoppoth

Publications and source records attributed to Ingeborg Schafhalter-Zoppoth.

14 recordsLinked to original sources
PubMed2003

Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon.

Signaling pathways involving protein kinase C isozymes are modulators of cardiovascular development and response to injury. Protein kinase C epsilon activation in cardiac myocytes reduces necrosis caused by coronary artery disease. However, it is unclear whether protein kinase C epsilon function is required for normal cardiac development or inducible protection against oxidative stress. Protein kinase C delta activation is also observed during cardiac preconditioning. However, its role as a promoter or inhibitor of injury is controversial. We examined hearts from protein kinase C epsilon knock-out mice under physiological conditions and during acute ischemia reperfusion. Null-mutant and wild-type mice displayed equivalent base-line morphology and hemodynamic function. Targeted disruption of the protein kinase C epsilon gene blocked cardioprotection caused by ischemic preconditioning and alpha(1)-adrenergic receptor stimulation. Protein kinase C delta activation increased in protein kinase C epsilon knock-out myocytes without altering resistance to injury. These observations support protein kinase C epsilon activation as an essential component of cardioprotective signaling. Our results favor protein kinase C delta activation as a mediator of normal growth. This study advances the understanding of cellular mechanisms responsible for preservation of myocardial integrity as potential targets for prevention and treatment of ischemic heart disease.

Animals↗
PubMed2003

Sciatic nerve block in a child: a sonographic approach.

UNLABELLED: Ultrasound technology can facilitate peripheral nerve blocks in clinical practice. In this case report, ultrasound imaging was used to identify the sciatic nerve and guide local anesthetic injection in the subgluteal region of a child undergoing Achilles tendon lengthening. Sonographic guidance may be especially useful for peripheral nerve blocks in children because the neural imaging is often excellent and reference landmarks are variable. IMPLICATIONS: In this case report, ultrasound was used to identify the sciatic nerve and guide local anesthetic injection in the subgluteal region of a child. Sonographic guidance may be especially useful for peripheral nerve blocks in children because the neural imaging is often excellent and reference landmarks are variable.

Achilles Tendon↗
PubMedDate not supplied

The musculocutaneous nerve: ultrasound appearance for peripheral nerve block.

BACKGROUND AND OBJECTIVES: To gain complete anesthesia of the forearm, block of the musculocutaneous nerve is necessary. Variations in its course and position make localization of the musculocutaneous nerve problematic. The aim of the study is to describe the ultrasound appearance of the musculocutaneous nerve in the axilla and to suggest potential areas to target neural block. METHODS: We scanned the axillary regions of 19 volunteers and assessed the size and shape of 34 musculocutaneous nerves at entry into, exit from, and in the center of the coracobrachialis muscle. Furthermore, we measured the depth of the musculocutaneous nerve under the skin surface and its distance from the axillary artery at those 3 measurement points. RESULTS: As it travels through the coracobrachialis muscle, the musculocutaneous nerve changes in shape from oval to flat-oval to triangular. During this course, the musculocutaneous nerve also separates from the axillary artery and becomes more lateral while changing its depth from the surface. The musculocutaneous nerve increases its transverse area along this nerve path. In 2 subjects, the musculocutaneous nerve could not be visualized unilaterally within the course of the coracobrachialis muscle. CONCLUSIONS: Knowledge of its ultrasound appearance facilitates localization and successful block of the musculocutaneous nerve. Because the distance between the musculocutaneous nerve and brachial plexus varies, different locations of musculocutaneous nerve puncture during ultrasound-guided regional anesthesia can be chosen.

Axillary Artery↗
PubMedDate not supplied

Ultrasound guidance for ulnar nerve block in the forearm.

OBJECTIVE: The objective of this study was to establish the feasibility of ulnar nerve block under direct imaging. CASE REPORTS: Two patients undergoing surgery on the fifth digit or medial hand received ulnar nerve blocks in the mid-forearm (approximately 15 cm proximal to the styloid process of the ulna). Ultrasound imaging was used to identify the ulnar nerve in the forearm and guide local anesthetic infiltration. Both patients had successful blocks, including sensory anesthesia of the dorsomedial hand. CONCLUSIONS: Ultrasound guidance for ulnar nerve block in the forearm is a promising technique that includes block of the dorsal cutaneous branch. Anatomic and sonographic considerations are discussed.

Adult↗
PubMedDate not supplied

Ultrasound visibility of needles used for regional nerve block: an in vitro study.

BACKGROUND AND OBJECTIVES: Ultrasound visibility of regional block needles is a critical component for safety and success of regional anesthetic procedures. The aim of the study was to formally assess factors that influence ultrasound visibility of needles used in regional anesthesia. METHODS: Regional block needles between 17- and 22-G diameter were inserted in a tissue equivalent phantom at angles from 0 degrees to 65 degrees relative to the phantom surface. For visibility enhancement, the needles were primed with air or water in combination with stylets and different size guide wires. Ultrasound measurements of needle tips and shafts were performed using transversal and longitudinal imaging with a linear 15-MHz transducer. Univariate and multivariate statistical analyses were performed on 719 visibility measurements. RESULTS: Hustead tip needles exhibited best ultrasound visibility. Ultrasound visibility of the needle tip was increased by insertion of a medium size guide wire. Water or air priming of the needle, insulation, and the insertion of a stylet did not influence needle visibility. Long axis imaging of the needle for shallow insertion angles (<30 degrees in relation to the phantom surface) and short-axis imaging for steep angles (>60 degrees ) provided the best ultrasound visibility of the needle tips. Needle visibility decreased linearly with steeper insertion angles ( P <.001) and smaller needle diameters ( P <.001). CONCLUSIONS: The results of our in-vitro study suggest a number of factors enhancing ultrasound visibility of regional block needles. The use of needles in the largest possible size inserted with a medium-size guide wire provides the best ultrasound visibility. Analysis of the approach angle favors needle insertion parallel to the transducer. The consideration of these factors may improve safety and success of ultrasound-guided regional blocks.

Equipment Design↗