Biomedical subjects
Publications and source records attributed to Imtiaz Ahmed.
We present a case of leiomyoma oesophagus which was presented in our surgical outpatient department with symptom of dysphagia for the last one year. Patient was investigated and diagnosed as a case of benign oesophageal neoplasm. She was successfully treated by transthoracic enucleation in our surgical unit at PIMS, Islamabad.
Previously we reported the identification of RPR200765A, a potent orally bioavailable pyridine-imidazole inhibitor of p38 mitogen-activated protein (MAP) kinase which suppressed paw swelling and joint pathology in streptococcal cell wall-induced arthritis. Herein, we report the use of solid-phase combinatorial organic synthesis for the parallel processing of a related pyrimidine-imidazole-based library with two points of structural variability. We report also that the application of a computer algorithm, the Monte Carlo Monomer Selection, maximized both the combinatorial synthetic efficiency and the bioavailability of the final compounds. In conjunction with the synthetic protocols, the polymer-supported quench technique was applied to the purification of the final compounds. Through rapid evaluation of the library using a p38 kinase assay and permeability assays, it was possible to identify a number of potent and orally bioavailable p38 MAP kinase inhibitors suitable for further biological investigation.