Biomedical subjects

Igor Mezić

Publications and source records attributed to Igor Mezić.

4 recordsLinked to original sources

PubMed2005

Control of particles in microelectrode devices.

The impact of the convective fluid motion induced by the electric fields on the dielectrophoretic manipulation of particles is investigated theoretically and experimentally. By means of a simplified model a channel with a periodic array of microelectrodes we show that electroconvective flows induce the formation of traps for particles, providing a dynamical mechanism to control microparticles in such devices. We demonstrate experimentally the theoretically predicted dynamical phenomena.

Journal Article↗

PubMed2004

Capture into resonance: a method for efficient control.

To achieve large changes in adiabatic invariants using small control input, a conservative dynamical system must possess an internal resonance. Capture into resonance is an inherently probabilistic process. We propose a control method to make it more structured. We study the motion of charged particles in an electromagnetic field as an example of such a system. When the nominal dynamics brings particles close to a resonance surface, a short control pulse forces the capture of a particle into the resonance with the wave. A captured particle is transported by the wave across the energy levels. The second pulse releases a particle from the resonance when the desired energy level is achieved. We discuss the distribution of energy achieved by the method.

Journal Article↗

PubMed2004

Mixing in the shear superposition micromixer: three-dimensional analysis.

In this paper, we analyse mixing in an active chaotic advection micromixer. The micromixer consists of a main rectangular channel and three cross-stream secondary channels that provide ability for time-dependent actuation of the flow stream in the direction orthogonal to the main stream. Three-dimensional motion in the mixer is studied. Numerical simulations and modelling of the flow are pursued in order to understand the experiments. It is shown that for some values of parameters a simple model can be derived that clearly represents the flow nature. Particle image velocimetry measurements of the flow are compared with numerical simulations and the analytical model. A measure for mixing, the mixing variance coefficient (MVC), is analysed. It is shown that mixing is substantially improved with multiple side channels with oscillatory flows, whose frequencies are increasing downstream. The optimization of MVC results for single side-channel mixing is presented. It is shown that dependence of MVC on frequency is not monotone, and a local minimum is found. Residence time distributions derived from the analytical model are analysed. It is shown that, while the average Lagrangian velocity profile is flattened over the steady flow, Taylor-dispersion effects are still present for the current micromixer configuration.

Complex Mixtures↗

PubMed2003

Uniform resonant chaotic mixing in fluid flows.

Laminar flows can produce particle trajectories that are chaotic, with nearby tracers separating exponentially in time. For time-periodic, two-dimensional flows and steady three-dimensional (3D) flows, enhancements in mixing due to chaotic advection are typically limited by impenetrable transport barriers that form at the boundaries between ordered and chaotic mixing regions. However, for time-dependent 3D flows, it has been proposed theoretically that completely uniform mixing is possible through a resonant mechanism called singularity-induced diffusion; this is thought to be the case even if the time-dependent and 3D perturbations are infinitesimally small. It is important to establish the conditions for which uniform mixing is possible and whether or not those conditions are met in flows that typically occur in nature. Here we report experimental and numerical studies of mixing in a laminar vortex flow that is weakly 3D and weakly time-periodic. The system is an oscillating horizontal vortex chain (produced by a magnetohydrodynamic technique) with a weak vertical secondary flow that is forced spontaneously by Ekman pumping--a mechanism common in vortical flows with rigid boundaries, occurring in many geophysical, industrial and biophysical flows. We observe completely uniform mixing, as predicted by singularity-induced diffusion, but only for oscillation periods close to typical circulation times.

Journal Article↗