[Clinical significance of the chemotherapy dosage in gastric cancer].
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Biomedical subjects
Publications and source records attributed to Ia V Shparik.
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In 53 patients with gastric and intestinal cancer, the content and functional activity of the natural killer cells was studied. The suppression of these indices at the first days after the operation, and restoration of their preoperative levels within 2-2.5 weeks was noted.
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The author investigated the state of functional activity of the system of natural resistance in patients suffering of cancer of the gastrointestinal tract organs. It was established that in the course of development of the disease natural resistance reduced. The obtained data may be used for immunomonitoring in oncological clinical practice.
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Experimental and clinical data concerning the interaction of cytostatics with diuretics, anticoagulants, neurotropic drugs, prostaglandin inhibitors, etc. are reviewed. It is considered necessary to take into account the possible clinical effect when applying different drugs for treatment of the tumour patients. Side by side with intensification of the antitumour activity of the cytostatic or with a decrease of its toxic effect on haemopoiesis and on the function of parenchymatous organs some undesirable effects such as an increase of the toxicity or a decrease of the antitumour effect are possible. Interaction of cytostatics with different groups of drugs demands further study taking into account the "medicinal background" of the modern population.
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