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Biomedical subjects

Ia S Tsimmerman

Publications and source records attributed to Ia S Tsimmerman.

At least 19 recordsLinked to original sources
PubMed2006

[Helicobacter pylori infection: extragastric effects and diseases (a critical analysis)].

The article presents a critical analysis of the attempts of other authors to propagate the significance of Helicobacter pylori (HP) infection in the origin and development of a range of extragastric diseases and syndromes. From the position of evidence-based medicine, the author of the article discusses the possibility of HP participation in the development of such diseases as cholelithiasis, primary sclerosing cholangitis, pancreobiliary cancer, hepatic encephalopathy in hepatic cirrhosis, pancreatic diseases, inflammatory bowel diseases, atherosclerosis, coronary heart disease, allergic diseases etc. The author concludes that the attempts to associate the development of these diseases with HP infection are in general unfounded and not evidence-based. The author also adduces his own data on the role of the mucose microflora (other than HP) in the pathogenesis of duodenal ulcer relapses, and the effects of differentiated antimicrobial therapy, which are not less prominent than those of HP eradication.

Anti-Bacterial Agents↗
PubMed2006

[The ethiology, pathogenesis, and treatment of Helicobacter pylori-associated peptic ulcer: the status of the problem and the prospects].

The author presents an objective, evidence-based analysis of the main conceptions of the infectious theory of peptic ulcer (PU), critically discussing such postulates as "no Helicobacter pylori (HB), no PU", "HP is a pathogen that presents the main cause of PU", "a good HP is a dead HP", "HP eradication leads to complete recovery from PU", etc. The article presents original author's concepts on interrelations between HP infection and the human organism, and the pathogenesis of HP-associated PU. The consequences of the practical realization of the recommendations of Maastrich Consensus on HP eradication are discussed. The data of the author's studies dedicated to the ways of increasing the effectiveness of treatment of HP-associated PU, based on the author's conception of its pathogenesis, are adduced.

Anti-Infective Agents↗
PubMed2006

[Chronic cholecystitis and its clinical masks: diagnosis and differential diagnosis].

The author adduces modern data on the ethiology and pathogenesis of chronic cholecystitis and the stages of the development of biliary pathology (motorotonic disturbances of the gall bladder and the sphincter apparatus of the extrahepatic biliary tract - chronic acalculous cholecystitis - chronic calculous cholecystitis). He considers in detail the methods of diagnostics of chronic cholecystitis paying special attention to clinical (non-instrumental) methods. The author offers an original classification of physical symptoms of chronic cholecystitis, distinguishing three groups of symptoms according to their pathogenesis and clinical significance: segmentary reflectory symptoms ("exacerbation symptoms"); reflectory symptoms, localized in the right half of the body outside the segments of hepatobiliary system innervation ("severity symptoms"); irritative symptoms, observed during all the periods of chronic cholecystitis. The article contains a description of various clinical "masks" of chronic cholecystitis, which make the diagnosis more difficult: cardial, duodenal (gastrointestinal), rheumatic, solaralgic, allergic, pre-menstrual tension, and other masks, as well as a description of their differential diagnostic methods.

Cholecystitis↗
PubMed2006

[The effectiveness of SCENAR therapy in complex treatment of duodenal ulcer, and the mechanisms of its action].

A new technique of low-frequency modulated electric current therapy, SCENAR therapy, was used in treatment of 103 patients with duodenal ulcer (DU). The influence of SCENAR therapy on the main clinical and functional indices of a DU relapse was studied. It was shown that SCENAR therapy, which influences disturbed mechanisms of adaptive regulation and self-regulation, led to positive changes in most of the parameters under study. Addition of SCENAR therapy to the complex conventional pharmacotherapy fastened ulcer healing, increased the effectiveness of Helicobacter pylori eradication, and improved the condition of the gastroduodenal mucosa.

Adolescent↗
PubMed2006

[Post-cholecystectomy syndrome: the modern view of the problem].

The authors summarize and systematize literature data and their own observations concerning post-cholecystectomy syndrome (PCES), the reasons for and the mechanisms of its development, its clinical variants etc. The authors suggest the following PCES forms should be distinguished: functional ("egenuine") forms, which develop due to gall bladder removal and the loss of its functions, and organic ("conditional") PCES forms, which develop as a consequence ofaflawy surgery and/or preoperative complications of chronic calculous cholecystitis, which dominate in the postoperative clinical picture and are mistakenly considered cholecystectomy consequences. An original operational classification of PCES is adduced; possibilities provided by contemporary instrumental and laboratory techniques of differential diagnostics are considered; differential treatment and prophylaxis of PCES are described.

Diagnosis, Differential↗
PubMed2004

[Mental status of patients with ulcer disease].

Questionnaire survey has been performed among 100 patients with duodenal ulcer (DU). Character building of these patients when they were children and adolescents was wring in 80 +/- 4 cases (women) and in 88.6 +/- 3.2 cases (men). Most significant negative factors were undercare, hypercare and living in incomplete family. The Leongard's questionnaire distinguishes various accentuations with prevalence of cycloid, epileptoid, emotive and demonstrative; anxiety scale was low. The Gissen personality questionnaire "Ego" confirmed frequent occurrence among DU patients of emotive, hysteroid, epileptoid features with non-flexible type of reaction. By Luscher's test, anxiety was low or moderate. Overall prevalence of personality disorders totalled 29 +/- 4.5 cases, mostly in women. It was proved experimentally that psychosomatic disorders are realized in target organs. In DU these organs were gastrointestinal (36 +/- 5.7 cases). Similar data about involvement of the gastrointestinal tract (GIT) were obtained in stress reactions. However, "ulcer personality" was not documented. Support of preferable realization of psychogenic factors action in GIT was obtained with Gissen somatic questionnaire. Operating psychogenic factors and their dynamics were characterized; emotional deprivation was leading. Among psychopathological manifestations, asthenodepressive symptoms prevailed in 76 +/- 4.3 cases. High efficiency of gestalt-psychotherapy and coaxil in the treatment of DU in patients with psychopathological disorders of the neurotic level were found.

Adult↗
PubMed2003

[The state of immune system and effects of current therapy and immunomodulators].

To test the conception about a pathogenetic role of correlation between gastric comtamination with Helicobacter pylori (Hp) and immune system disorders in duodenal ulcer (DU), immune status and its response to current pharmacotherapy were studied in 84 patients in an acute recurrence phase. The patients were divided into 4 representative groups to receive monotherapy with omeprasol (group 1), combination denol + amoxicillin + tinidasol (group 2), quadrotherapy with drugs of group 1 and 2 (group 3), the above quadrotherapy plus immunomodulating drugs (imunofan + tactivin + oligovit) (group 4). In recurrent DU all the components of the immune system are affected especially cellular immunity. The response to the treatment was highest in group 1 and 4 (90% healing for 3 weeks), the worst in group 2 (68%). The complex of antibacterial drugs produces a moderate immunosuppressive action. The addition of immunomodulating drugs to the quadrotherapy promotes correction of secondary immunodeficiency and secondary Hp resistance to antibacterial drugs. This leads to a rise in eradication effect from 33-55 to 84% and a decrease in the number of early recurrences (during the first 6-12 months) from 42.1-33.6 to 12.5%.

Adjuvants, Immunologic↗
PubMed2003

[Physiotherapeutic treatment of gastroduodenal ulcer].

The review presents 69 references of current literature on the problem of gastroduodenal ulcer physiotherapy which has a good potential of impact on gastroduodenal motility, lipid peroxidation, microcirculation, physiological and reparative regeneration of epithelial and glandular cells. The choice of a physiotherapeutic method depends on the disease stage and to a less extent on location of the ulcer defect.

Duodenal Ulcer↗