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Biomedical subjects

I van der Sluis

Publications and source records attributed to I van der Sluis.

13 recordsLinked to original sources
PubMed2000

Body composition abnormalities in children with Prader-Willi syndrome and long-term effects of growth hormone therapy.

Obesity and hypothalamic GH deficiency contribute in different ways to the disturbances of body composition in Prader-Willi syndrome (PWS); while both increase the fat compartment, the reduction of lean tissue mass has been attributed mainly to GH deficiency. Therefore, body composition measured by dual-energy X-ray absorptiometry was prospectively studied in 12 overweight children with PWS and weight for height (WfH) SDS >0 before and during 3.5 years of treatment with hGH (0.037 mg/kg/day) on average. In the long term, there is a net reduction of body fat from 3.1 to 1.2 SD, with a minimum at the end of the second year of treatment. WfH SDS correctly reflects body fat mass and its changes. The initial deficit of lean mass (-1.6 SD) is counteracted by GH only during the first year of therapy (increase to -1.25 SD). But in the long term, GH therapy does not further compensate for this deficit, when lean mass is corrected for its growth-related increase. In conclusion, exogenous GH changes the phenotype of children with PWS: fat mass becomes normal, but, at least in the setting studied, GH is not sufficient to normalize lean tissue mass.

Absorptiometry, Photon↗
PubMed1994

Agglutination, adherence, and root colonization by fluorescent pseudomonads.

Two fractions of agglutination activity towards fluorescent pseudomonads were detected in root washes of potato, tomato, wheat, and bean. High-molecular-mass (>10 Da) components in crude root washes agglutinated only particular saprophytic, fluorescent Pseudomonas isolates. Ion-exchange treatment of the crude root washes resulted in preparations of lower-molecular-mass (10 to 10 Da) fractions which agglutinated almost all Pseudomonas isolates examined. Also, components able to suppress agglutination reactions of pseudomonads with the lower-molecular-mass root components were detected in crude root washes of all crops studied. Pseudomonas isolates were differentially agglutinated by both types of root components. The involvement of these two types of root components in short-term adherence and in colonization was studied in potato, tomato, and grass, using Pseudomonas isolates from these crops. Short-term adherence of isolates to roots was independent of their agglutination with either type of root components. With agglutination-negative mutants, the high-molecular-mass components seemed to be involved in adherence of Pseudomonas putida Corvallis to roots of all crops studied. Short-term adherence to roots of four Pseudomonas isolates could be influenced by addition of both crude and ion-exchange-treated root washes, depending on their agglutination phenotype with these root wash preparations. Potato root colonization by 10 different isolates from this crop, over a period of 7 days, was not correlated with their agglutination phenotype. Agg mutants of P. putida Corvallis were not impaired in root colonization. It is concluded that the root agglutinins studied can be involved in short-term adherence of pseudomonads to roots but do not play a decisive role in their root colonization.

Journal Article↗
PubMed1988

Effects of cadmium on consumption, assimilation and biochemical parameters of Daphnia magna: possible implications for reproduction.

1. The effects of cadmium on consumption, assimilation rates and biochemical parameters of Daphnia magna were determined. 2. The consumption and assimilation rates of 14 days 1.0 ppb Cd treated animals tended to decrease slightly, the decline of these rates at 5.0 ppb Cd (14 days), however, was highly significant (P less than 0.001). 3. The assimilation efficiencies of daphnids exposed to cadmium did not significantly differ from control. 4. No notable changes in the biochemical composition of daphnids could be noticed after 7, 14 and 21 days of cadmium exposure. 5. It seems as if not one metabolic process in particular was depressed due to cadmium, but metabolic activities seemed to be inhibited on the whole. 6. Results are discussed in relation with data of a previous study on the reproduction of D. magna under cadmium stress.

Animals↗