Biomedical subjects

I Zini

Publications and source records attributed to I Zini.

76 records · Page 5Linked to original sources

PubMedDate not supplied

Neuroendocrine control of basal insulin secretion in man: a study with bromocriptine, clonidine and naloxone.

The effects of bromocriptine (CB-154, 2.5 mg po), clonidine (0.05 mg im) and naloxone (0.4 mg im), as well as the interaction between naloxone and CB-154 or clonidine on basal insulin secretion were studied in 6 normal men. Clonidine, naloxone and CB-154 plus naloxone lowered insulin plasma levels; CB-154 alone caused only a slight reduction, whereas clonidine plus naloxone did not affect insulin secretion. These results prove the existence of a complex neuroendocrine control of basal insulin secretion through dopaminergic, adrenergic and opiate mechanisms; they also suggest that the opiate inhibitory control of insulin release may be dissociated from the dopaminergic one, but may interact with the adrenergic one.

Adult↗

PubMedDate not supplied

Neuropeptide Y produces anxiolytic effects in spontaneously hypertensive rats.

The sedative and anxiolytic effects of intracerebroventricular administration of neuropeptide Y (NPY) were studied in spontaneously hypertensive rats (SHR) and in normotensive Wistar-Kyoto (WKy) rats using the two-compartment exploratory test, and in the open-field test after habituation. In the two-compartment tests, NPY produced anxiolytic effects by increasing the exploratory activity in SHR at a dose (0.25 nmol) lower than the minimal effective dose in WKy rats (1.25 nmol). In SHR, anxiolytic effects were observed for the whole NPY dose range (0.25-5.0 nmol), whereas in normotensive WKy rats the highest dose (5.0 nmol) failed to increase exploratory activity. The open-field test showed reduced locomotor activity and rearings in WKy rats when injected with 5.0 nmol NPY. These effects were not observed in SHR. The absence of sedative effects and the higher sensitivity to the anxiolytic effects of NPY in SHR are suggestive of a genetically determined difference in central NPY systems involved in behavioral adaptation that may be relevant for the development of hypertension.

Animals↗

PubMedDate not supplied

Prosthetic rehabilitation following major nasal resection.

Treatment of extensive carcinoma of the external nose has as an objective the eradication of disease and rehabilitation of the patient. We review our experience with 15 patients treated with total and subtotal rhinectomy. Prosthetic rehabilitation offers prompt recovery of both cosmesis and function without morbidity. We conclude that prosthetic reconstruction of major nasal defects deserves consideration when rehabilitation following rhinectomy is required.

Carcinoma, Squamous Cell↗

PubMedDate not supplied

Nerve cell clusters in dorsal striatum and nucleus accumbens of the male rat demonstrated by glucocorticoid receptor immunoreactivity.

Glucocorticoid receptor-immunoreactive nerve cells have been analysed in the dorsal striatum and nucleus accumbens of the rat by means of a monoclonal antibody against rat liver glucocorticoid receptor. Glucocorticoid receptor immunoreactivity was present in the nuclei of the vast majority of the striatal nerve cells. The analysis of sections stained with glucocorticoid receptor antibody and cresyl violet showed that around 90% of the entire striatal neuronal population contained glucocorticoid receptor immunoreactivity. By means of the double immunoperoxidase technique evidence was provided that somatostatin- and choline acetyltransferase-immunoreactive nerve cells in the striatum do not contain glucocorticoid receptor immunoreactivity. The density of glucocorticoid receptor-immunoreactive nerve cells in the grey matter and the presence of clusters of glucocorticoid receptor-immunoreactive nerve cells have been investigated in three fields located in the medial and central dorsal striatum and nucleus accumbens at the coronal level A 8620 microns according to the König and Klippel atlas using computer-assisted image analysis. Every aggregate containing three or more glucocorticoid receptor-immunoreactive nerve cells, which had an intercenter distance less than the mean diameter (10-11 microns) of the striatal cells, was considered an island. A higher density of both glucocorticoid receptor-immunoreactive nerve cell nuclei and islands was found in the nucleus accumbens with respect to dorsal striatal areas. The most frequent island formed consisted of three to ten nerve cells both in dorsal striatum and nucleus accumbens. Furthermore, some nucleus accumbens islands contained up to 100 nerve cells, whereas in the dorsal striatum the maximum number of glucocorticoid receptor-immunoreactive nerve cells per island ranged from 50 to 60. The present procedure proved to be a sensitive method to reveal clusters of chemically identified structures and provided evidence for a basic cytoarchitectonic organization of the dorsal striatum and nucleus accumbens of the rat. This paper also demonstrated that the vast majority, but not all, striatal nerve cells contained glucocorticoid receptor immunoreactivity, and thus may be under the control of circulating glucocorticoids. In fact, only small transmitter-identified neuronal populations, such as somatostatin- and choline acetyltransferase-immunoreactive nerve cells, were devoid of glucocorticoid receptor immunoreactivity.

Animals↗