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Biomedical subjects

I Yoshikawa

Publications and source records attributed to I Yoshikawa.

8 recordsLinked to original sources
PubMed1991

[Evaluation of SPECT with N-isopropyl [I-123]-p-iodoamphetamine (IMP) or technetium-99m [99mTc]-d,l-hexamethylpropyleneamine oxime (d, 1-HM-PAO) in cerebral concussion].

123I-IMP and Tc-PAO SPECT were performed in 20 cases of cerebral concussion ranging in age from 4 to 20 years old, including six cases of the juvenile head trauma syndrome (JHTS). The SPECT findings were divided into two main types: six cases in the normal group with no blood flow abnormalities, and 14 cases in abnormal group showing reduced blood flow, mainly in cerebellum and occipital lobe except in one case. In 10 cases with reduced blood flow which could be analyzed, calculation of the blood flow ratio in the temporal and occipital lobes and the cerebellum with the frontal lobe taken as 100 showed values of 93.5% for the temporal lobe, 82.7% for the occipital lobe and 76.8% for the cerebellum. A statistically significant reduction in blood flow occurred in the occipital lobe and cerebellum. In blood examination, abnormally high values of white blood cell counts were observed transiently in 94% of cerebral concussion cases. Abnormalities in brain stem and hypothalamus appeared to cause these abnormal WBC values. From these findings, it was suggested that the blood flow regions of the basilar and posterior cerebral arteries, i.e., the brain stem and hypothalamus are closely connected with the lesions responsible for cerebral concussion. It also appeared that the JHTS occurs in cerebral concussion cases where recovery of the abnormal blood flow in these regions in poor.

Adolescent↗
PubMed1991

[The distribution of solutions in the epidural space].

In 21 patients the distribution within the epidural space of epidurally injected 99mTc-DTPA was assessed. The gamma emissions from the epidural space were measured externally with the patients in supine position by use of a gamma camera. The recordings over the patient's back were stored in digital computer for 60 min. The results were as follows; 1) The spread of the radionuclide was mainly to cephalad direction, and seldom crossed the L5 level to sacral region. 2) The solution injected in the epidural space would distribute to less resistant compartments and the spread depends on the power of injection, negative pressure in the high epidural space and capillary pressure. 3) The elimination half-life of the injected radionuclide was between 1 to 17 min depending on the region in the epidural space. 4) The solution injected in the epidural space may penetrate dura mater at the ink cuff area and local anesthetic agents may affect the spinal nerve roots in the subarachnoid space rather than at the extra-dural space. 5) With continuous infusion technique the diffusion and penetration of the local agent through the dura mater are facilitated and more profound anesthetic effects would be expected. In clinical practice the utilization of the continuous infusion method should be considered along with the bolus injection.

Adult↗
PubMed1990

[Delayed Sumithion intoxication].

A case of delayed Sumithion (fenitrothion) intoxication is reported. A 52-year-old man ingested 10 ml of Sumithion in order to commit suicide with alcohol and triazoram. Several hours later, he was admitted to our hospital because of clouding consciousness. On admission, he was somnolent, but had no other symptoms, especially suggested organophosphorus intoxication. After 40 hours, fasciculation and salivation, which are early symptoms of organophosphorus intoxication, gradually appeared. The concentration of Sumithion in the blood was measured during the course and its metabolism was represented phalmacokineticaly by a 2-compartment model. The retarded metabolism of the Sumithion was suggested by this model. It is considered that the retarded metabolism of Sumithion caused the delayed intoxication.

Biotransformation↗
PubMed1989

[Characteristics of the effect of 16,16-dimethyl prostaglandin E2 on the alkaline secretion of the proximal duodenal mucosa in rats--a comparison with the effect of secretin].

Effect of intravenous infusion of 16,16-dimethyl prostaglandin E2 (16,16-dmPGE2) on the alkaline secretion of the proximal duodenal mucosa was investigated using a lumen perfusion system of the duodenal loop in rats. The following results were obtained: 1) 0.001 to 1 microgram/kg/hr of 16,16-dmPGE2 increased the alkaline secretion significantly and dose-dependently. 2) Indomethacin (5 mg/kg) inhibited the alkaline secretion and 16,16-dmPGE2 (0.1 microgram/kg/hr) completely repaired this inhibition. 3) In cysteamine-treated rats, 16,16-dmPGE2 (1 microgram/kg/hr) completely repaired the inhibition of the alkaline secretion induced by cysteamine. 4) Prostaglandin was a potent stimulator of alkaline secretion of the proximal duodenal mucosa not only in cysteamine-treated rats but also in normal rats. This is in contrast to our previous report which showed that secretin repaired the alkaline secretion in cysteamine-treated rats without affecting it in normal rats. We have concluded that prostaglandin and secretin may be involved differently in the mechanism of alkaline secretion of the proximal duodenal mucosa. Further investigation is required to elucidate the mechanism.

16,16-Dimethylprostaglandin E2↗