[Immigration and AIDS].
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Biomedical subjects
Publications and source records attributed to I Wessel.
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Social phobia is often accompanied by somatic symptoms such as trembling, blushing, and sweating. In cases where these symptoms are predominant and, rather than the social situation, represent the feared stimulus, their unpredictable occurrence may reduce the effectiveness of an otherwise successful treatment, such as exposure in vivo. In this study, a paradoxical treatment approach, combined with rational emotive therapy, is employed with three social phobic patients with fears of blushing, trembling, and sweating, respectively. Results indicate that a paradoxical treatment may be an effective strategy in reducing somatic symptoms in social phobia.
1. The specific activity of UDPglucose 4-epimerase (EC 5.1.3.2) increases by about 50% during the first 24 h of starvation-induced differentiation (spherulation) of Physarum polycephalum. 2. At all stages during differentiation, the enzyme activity is very sensitive to actinomycin-C and cycloheximide, inhibitors of transcription and translation, with a half life against cycloheximide of about 20 min (if added 12 h after the induction of differentiation). 3. The isoenzyme pattern, as revealed by isoelectric focusing in sucrose gradients, does not change during spherulation. One main band with a pI of 6.7, with a shoulder (pI 7.6) and a minor band (pI 6.0) was observed in extracts both from growing and differentiating cultures. 4. Density labelling experiments using deuterated amino acids with subsequent analysis by equilibrium density gradient sedimentation in 15-35% (w/w) metrizamide gradients revealed a rather slow rate of enzyme synthesis, which is in contrast to the observed high sensitivity against actinomycin-C and cycloheximide.
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