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Biomedical subjects

I Voinescu

Publications and source records attributed to I Voinescu.

32 records · Page 2Linked to original sources
PubMedDate not supplied

[The effect of some beta-blocking drugs on plasma renin activity, platelet adhesiveness and dilute blood clot lysis time in patients with essential arterial hypertension].

Propranolol (160--240 mg/24 h) and Oxprenolol (80--240 mg/24 h) were given for different periods of time to 13 and, respectively, 7 patients with essential arterial hypertension stage II. Both these beta-blocking drugs induced a significant fall in plasma renin activity : after ten days of treatment, platelet adhesiveness decreased in the patients with a basal level over 50% and increased in those with basal level below 30% (p < 0.01). When this treatment was given for 30 consecutive days, platelet adhesiveness decreased even in the latter patients. The drugs were also found to accelerate dilute blood clot lysis time in patients who presented a delayed lysis time before therapy. Thus, it is inferred that both propranolol and oxprenolol eliminate, at least partly, several factors involved in the pathogenesis of atherosclerosis, a frequent complication of essential arterial hypertension.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

"Spontaneous" recovery in aphasics after single ischaemic stroke.

In a homogeneous group of 75 aphasics after single ischaemic stroke, randomly selected, performance tests were carried out two weeks and one, three and six months post-onset. None of them were systematically treated. Both for the global performance and for repetition, naming, auditory comprehension, reading comprehension, writing under dictation as well as for the communicative value of a standard interview, "spontaneous" recovery was more marked during the first three months and obviously reduced between three and six months post-onset. In 28 of these aphasics, the clinical form changed from a severe to a milder form, the fluent or nonfluent character remaining unchanged. Clinical form influenced recovery by the severity of aphasia or by certain symptoms. Initial severity is quite important in recovery, very severe cases being unfavored, severe and mild cases reacting better, while moderate cases recovered the best. Associated oral apraxia had a negative influence while age had a minor effect and sex a doubtful one.

Adult↗