Search PubMed⌕ Search

Biomedical subjects

I Villa Elizaga

Publications and source records attributed to I Villa Elizaga.

14 recordsLinked to original sources
PubMed1993

[Relationship between primary lactose malabsorption and consumption of dairy products].

This study was designed to determine the influence of lactose malabsorption on the consumption of dairy products. We studied 157 children and 43 adults. The Breath-hydrogen test was used to define their level of lactose digestion. The prevalence of lactose maldigesters was 12%. We found a large relationship between the consumption of milk and milk products and age. Malabsorbers consumed more fermented dairy products (ripened cheese and yogurt) than did absorbers (p < 0.05). Subjects with normal lactose absorption consumed more milk, butter, cream cheese and global lactose than the maldigesters (p < 0.05). Lactose intolerance, familiar consumption and geographic origins had little influence on an individual's consumption habits.

Adolescent↗
PubMed1993

[Study from Navarra. Variations in the average arterial blood pressure level according to age, gender and body height].

As part of an epidemiological study on cardiovascular risk factors among children and adolescents in Navarra, arterial blood pressure (BP) readings were taken in 5,829 children, including both sexes and aged between 4 and 17 years. The subjects were randomly selected from the public and private school population in our community. BP-age and BP-height percentiles were obtained for each sex and the physiological variations in BP according to these parameters was also analyzed. Systolic BP increased with age in both sexes throughout childhood. During adolescence, there is almost no variation in BP among girls, but in boys older than 13 years, there is a sudden increase. For this reason, boys have higher values than girls. Diastolic BP shows a linear increase in both sexes. BP increases with height in both sexes. In spite of the sudden rise in systolic BP among the boys taller than 145 cm, the increase in systolic BP in relationship to height is smaller and more homogeneous than the increase seen with age. As the BP variations with height are smaller and more homogeneous than those related to age, it is preferable to evaluate this parameter by BP-height rather than by BP-age.

Adolescent↗
PubMed1993

[Study from Navarra. Hyperlipidemia II. Variations according to age and sex in the average cholesterol level, LDL-cholesterol and triglycerides in an infant-child population].

As part of an epidemiological study on cardiovascular risk factors among children and adolescents in Navarra, lipids and lipoproteins were analysed in 5,829 children. The study group was selected at random from the school population in our community and included students of both sexes between 4 and 17 years of age. In this article we describe the variations from 4 to 10 years of age in both sexes and decrease from that age on. Among males older than 14, they continue decreasing, while they become stable in females. For this reason, values during childhood are higher than during adolescence in both sexes, and within this period, males show lower levels than girls. Variations in LDL serum levels according to age and sex are similar to those recorded with cholesterol. The triglyceride serum levels increase in line with age among boys. With girls, something similar happens until they are 13. Starting from this age, there is an inversion showing lower levels than the male adolescents. In both sexes, levels during adolescence are higher than during childhood.

Adolescent↗
PubMed1993

[Chronologic study of signs of myocardiopathy in progressive muscular dystrophy].

In order to analyze the evolution of cardiomyopathy in progressive muscular dystrophies, thirty-three patients (17 with Duchenne type, 11 with Becker type and 5 with the autosomal recessive type dystrophy) were studied retrospectively. Cardiac and systemic follow-up every 3-6 months was made in 29 patients. The electrocardiogram was the first test that became altered, followed by the echocardiogram and thoracic radiograph and finally heart failure manifestations. There was a direct correlation between age and the appearance of abnormal cardiac tests. Electrocardiographic alterations, in patients who were less than 12.5 years of age, were significantly more frequent in the group with Duchenne dystrophy that in the no-Duchenne group. In regards to the appearance of the echocardiographic and radiographic abnormalities, there were no significant differences between the two groups. However, we have noticed a trend towards a more frequent and earlier presentation of these abnormalities in the Duchenne's muscular dystrophy than in the no-Duchenne group.

Cardiomyopathies↗
PubMed1993

[The Navarra study (PECNA). Hyperlipidemia III. Variations in the median HDL levels and lipid risk quotient in children and adolescents based on age and gender].

As part of an epidemiological study on cardiovascular risk factors among children and adolescents in Navarra, lipids and lipoproteins were analyzed in 5,829 children of both sexes. The subjects were between 4 and 17 years of age and were selected at random from the school population in our community. In this article we analyze the variations in HDL-cholesterol and cholesterol/HDL and LDL/HDL risk quotients according to age and sex. Beginning at the age of 10, the HDL decreases in both sexes, although this decrease is more evident among males and they obtain levels lower than those during early childhood. Among females older than 14 there is a slight increase. Apparently the decrease in HDL among male adolescents is due to an increase in the production of testosterone during this stage of life. Both risk quotients decrease until the children are 10 years of age, after which they increase among males and stabilize or slightly decrease among females. For this reason, scores are higher for males during the last years of adolescence. The cardiovascular lipid risk increases with age and during adolescence in higher among males and depends more on the variations in HDL than on variations in cholesterol or LDL. We believe that the best definition for cardiovascular lipid risk during the infancy or adolescents is one which is based on the risk quotients.

Adolescent↗
PubMed1993

[The Navarra study (PECNA). Hyperlipidemia IV. Prevalence of hyperlipidemia in the infant- and juvenile population of Navarra. Variations based on age, gender and health care accessibility].

As part of an epidemiological study on cardiovascular risk factors among children and adolescents in Navarra, lipids and lipoproteins were analyzed in 5,829 children of both sexes. These children were between 4 and 17 years of age and were randomly selected from the school population of our community. In this article, we analyze the prevalence of lipid risk, according to its different definitions, among children and adolescents in Navarra, and its variations related to age, sex and sanitary area. The prevalence of hypercholesterolemia (C > 200 mg/dl) among children and adolescents, aged 4 to 17 years, is very high: 21.07% +/- 0.54%. In spite of having high serum levels of HDL, the lipid risk measured by the risk quotient LDL/HDL > 2.2 is still very high: 15-70% +/- 0.49%. If we define the lipid risk during childhood and adolescence by the quotient LDL/HDL > 2.2, male adolescents turn out to be the group with the highest risk. This phenomenon coincides with the results of the epidemiological studies made among adults. Nevertheless, they do not coincide with these results if the lipid risk is defined by C > 200 mg/dl. In our opinion, during infancy and adolescence, the lipid risk is better defined by the quotient LDL/HDL > 2.2.

Adolescent↗
PubMed1993

[A study from Navarra. Hyperlipidemia V. What is the best definition of hyperlipemia in childhood and adolescence?].

As part of an epidemiological study on cardiovascular risk factors among children and adolescents in Navarra, lipids and lipoproteins were analyzed in 5,829 children of both sexes, between 4-17 years of age, and selected at random from the school population in our community. In this article, we analyze the different definitions for lipid risk during childhood, whether based on percentile values, according to age and sex of the child, of cholesterol, LDL/cholesterol, or risk quotients (C/HDL, LDL/HDL), or even on the absolute values of all of these parameters. An appropriate definition for hyperlipemia during childhood, once we know the average variations in the levels of lipids and lipoproteins according to age and sex, as well as the variations of the lipid risk prevalence according to its definition, would be: 1. Previous screening according to cholesterol serum levels: Values higher than the 70th percentile for each group according to age and sex: or higher than 185 mg/dl for children age 4 to 12 and 170 mg/dl for children age 13 to 17. 2. To calculate the LDL/HDL quotient among those selected children included in the definition of hyperlipemia when the quotient is higher than the 85th percentile for the patients age and sex, or it is higher than 2.2.

Adolescent↗
PubMed1993

[The Navarra study. Prevalence of arterial hypertension, hyperlipidemia and obesity in the infant-child population of Navarra. Association of risk factors].

As part of an epidemiological study on cardiovascular risk factors among children and adolescents in Navarra, 5,829 children were studied. These children, of both sexes, were between 4 and 17 years of age and were selected at random from the public and private school population in Navarra. The prevalence of hypertension (HT) was 7.17 +/- 0.34%, hyperlipemia (LDL/HDL > 2.2) 15.70 +/- 0.49% and obesity (Quetelet I) 3.96 +/- 0.26%. Of the children and adolescents in Navarra 23.68% show some of these three associated risk factors. Obesity was significantly associated with HT and hyperlipemia, measured by LDL/HDL > 2.2 (but not when defined by cholesterol > 200 mg/dl). This association was greater when the pathology was defined by the Quetelet Index, rather than by the skinfold thickness. Hypertension was not associated with hypercholesterolemia (defined as LDL/HDL > 2.2). The association with hyperlipemia (measured by LDL/HDL) disappeared when the obesity effect was eliminated. It is deduced from these factors that if we don't take preventative health measures, the present children and adolescents from Navarra will suffer a high cardiovascular morbi-mortality when they become adults.

Adolescent↗
PubMed1991

Changes in the fetal tibial growth plate secondary to maternal zinc deficiency in the rat: a histological and histochemical study.

Zinc deficiency (ZD) is teratogenic in rats, and fetal skeletal defects are prominent. To elucidate further the effects of maternal ZD in the fetal skeleton, we performed a morphological and histochemical study of tibial growth plate (GP) in ZD rat fetuses. The histochemical study included the identification of calcium, of hydrolytic enzymes associated with the process of calcification, and of oxidative enzymes related to energy production and to the synthesis of proteoglycans. Pregnant Sprague-Dawley rats were fed (1) a control diet (76.4 micrograms Zn/g diet) ad libitum (group C), (2) a zinc-deficient diet (0 micrograms/g) ad libitum (group ZD), or (3) the control diet pair-fed to the ZD rats (group PF). On day 21 of gestation, laparotomies were performed, the fetuses were removed, and fetal tibiae obtained. Specimens were stained with hematoxylin-eosin (H&E) and Masson Trichrome and were processed for identification of alkaline phosphatase, adenosine triphosphatase, succinic dehydrogenase, NADH dehydrogenase, and calcium. The morphologic patterns found in ZD fetal tibiae indicated defects in various cell types implicated in bone metabolism. Staining for hydrolytic enzymes revealed alterations in the size and distribution of matrix vesicles and a weaker staining for ATPase in ZD fetuses. Staining for oxidative enzymes was overall more intense in ZD fetal tibiae. ZD fetuses also presented irregular and defective calcification. These findings indicate that severe maternal ZD in the rat results in structural and functional alterations in the GP of fetal bone, leading to a defective endochondral ossification.

Animals↗
PubMed1989

[Intraoperative radiotherapy in the multidisciplinary treatment of malignant tumors in children. Preliminary results].

From September 1984 to March 1989, 57 children received intraoperative radiotherapy as part of a multidisciplinary tumor treatment. Their age ranged from 2 to 18 years. Tumor types: osteosarcoma, 21; Ewing's sarcoma, 19; soft tissue sarcomas, 6; neuroblastoma, 5; Wilm's tumor, 3; Hodgkin, 1; glioma, 1, and malignant pheochromocytoma, 1. In 44 patients the disease was localized while 13 had distant metastases. Intraoperative radiotherapy was used in 48 previously untreated patients as part of a radical treatment program and in 9 cases as an effort to rescue local failures (5 in previously irradiated areas). The intraoperative radiation field included the surgically exposed tumor or tumor bed, and the single doses ranged from 10 to 20 Gy, with 6-20 MeV electrons. With a median follow up time of 25 months (4 to 51 + months) 44 out of 57 patients are alive without local recurrence and 13 have died from tumor (6 with local progression). Intraoperative radiotherapy seems to be a feasible treatment which might promote local control in pediatric tumors.

Adolescent↗
PubMed1986

Plasmatic zinc concentrations during pregnancy in zinc-deficient rats in relation to neonatal outcome.

Zinc has long been known to be an essential element for the growth and development of living things. In fact, zinc is present or participates in a wide variety of metabolic processes including the metabolism of carbohydrates, lipids, proteins and polynucleotides. The purpose of our study was to determine some aspects of the involvement of zinc in intrauterine growth and development of the rat. Thirty female Wistar rats were assigned at random to 1 of 3 dietary treatments. Group A received a normal diet, group B received a zinc-deficient diet and group C received a zinc-deficient diet plus a supplement of zinc in the drinking water. Daily food consumption, weights and plasmatic zinc levels were measured on days 1, 10 and 20. Fetal weights on day 20 were also recorded. The results showed a significant difference in daily food consumption and weight gains of the dams between the group receiving the normal diet (group A) and the other two groups. Fetal weights showed a different pattern, there was a significant difference between the unsupplemented zinc-deficient group B and the other two groups which led us to think that the daily food consumption of groups B and C, even though enough to produce lower weight in the dams, was not sufficiently low to produce fetal malnutrition and that it was the adequate consumption of zinc which allowed the fetuses of group C to have similar weights to those in group A, emphasizing the requirement of this metal for normal growth.

Animals↗
PubMed1979

[Perinatology].

Explore the source record for details and available documents.

Perinatology↗