[The 1st Congress of Toxicologists of Russia].
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Biomedical subjects
Publications and source records attributed to I V Vorontsov.
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The article deals with the process of medical reconnaissance organisation in various extreme situations, including local wars and armed conflicts. The authors suggest that there is a definite need in special units and mobile sanitary-epidemiological groups, trained and equipped for the task. They also recommend that these units should be formed up in the deployable medical set-ups.
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The work deals with the study of the possibility of using the passive hemagglutination inhibition test (antibody neutralization) for the determination of the antigenic activity of botulinum toxoids, types A, B and E. Erythrocytic diagnostic preparations were shown to allow the determination of up to 0.1 g of antigen. At the same time in vitro determinations were found to satisfactorily correlate with the results of in vivo determinations of the antigenic activity of these toxoids in the antitoxin-fixation test.
On the example of production of botulin toxoids of A, B and E types the authors demon strated the expediency of using the agar gel diffuse precipitation test for preliminary assessment of the toxoid activity, instead of a more expensive and complicated antitoxin-binding test.
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