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Biomedical subjects

I V Dvorakovskaia

Publications and source records attributed to I V Dvorakovskaia.

At least 19 recordsLinked to original sources
PubMed2006

[Endobronchial biopsy in the diagnosis of pulmonary sarcoidosis].

Bronchofiberscopy (BFS) with endobronchial biopsy (EBB) was performed in 66 patients with pulmonary sarcoidosis (PS). Transbronchial biopsy (TBB) was made in 49 patients from this group to compare the diagnostic value of EBB and TBB. The normal endoscopic picture was observed in 19.6% of patients. Bronchial mucosal hypervascularization and thickening were found in 25.7% of cases; the signs of enlarged bronchopulmonary lymph nodes were detected in 13.6%; catarrhal endobronchitis in 10.6%, and tuberosity changes in 4.5%. Epithelioid granulomas in the bronchial mucosa were identified in 37.8% of cases (30.75 and 39.6% in the intact and abnormal mucosa, respectively). The diagnostic value of TBB was 65.3%. EBB could reveal epithelioid-cell granulomas in 4 of the 17 patients with negative TBB. The findings suggest that BFS with EBB should be included as a necessary diagnostic method for the examination of patients with PS.

Adult↗
PubMed2005

[Effect of preoperative chemotherapy, mediastinal lymph node dissection and stump cover on bronchial regeneration following experimental pneumonectomy].

The dynamics of morphological changes occurring in the bronchial stump depending on the extent of mediastinal lymph dissection, preoperative chemotherapy and the stump cover method are discussed. Stump healing after right-side pneumonectomy was assessed in 32 non-inbred dogs. Typical procedure was tested in group 1 while complete systematic mediastinal lymph dissection (CSMLD)--in groups 2-4. In groups 3-4, pneumonectomy was performed after two courses of chemotherapy (cisplatin 80 mg/m2 per day + etoposide 120 mg/m2, days 1,3,5). In groups 1-3, the stump was covered with a parietal strap; in group 4, a m. latissimus dorsi strap was fixed on a vascular "pedicle". Experiment was suspended on days 3, 7, 14, 21 and 30. One animal in group 2 died of ischemic necrosis of the esophagus terminating in mediastinitis. None of the animals developed bronchial fistula. Angiography detected reduced blood flow in the right-side third of the trachea and medial surface of the left main bronchus in the CSMLD groups. Microscopically, all the groups revealed a similar pattern of stump healing. CSMLD did not influence bronchial stump regeneration significantly. Nor was it hampered in any way by preoperative chemotherapy. The latter was followed by expansion of necrotic and edematous area thus slightly affecting regeneration. Primary bronchoplasty failed to speed up regeneration, yet it might diminish the risk of bronchial fistula.

Animals↗
PubMed2004

[Vascular invasion by tumor in the absence of regional lymph node metastases in patients with locally advanced non-small cell lung cancer].

The study included 45 patients radically operated for locally advanced (T3, T4) non-small cell lung cancer (NSCLC), free from metastasis to the regional lymph nodes. The histological subtypes were: squamous cell cancer (40; 89%), adenocarcinoma (4; 6%) and large-cell lung cancer (1; 2%). Pathomorphological stage: IIb (p T3N0M0)--35 (78%); IIIb (p T4N0M0)--10 (22%). Blood vessel invasion: tumor T3--8 (23%); T4--2 (20%). Lymph vessel invasion: T3--9 (9%) and T4--2 (2%) (p(0.05). In total, tumor invasion was reported in 16 patients: T3--12 (34%) and T4--4 (40%) (p(0.05). There was no significant difference in survival among IIb or IIIb stage NSCLC patients. None of the cases of blood vessel invasion survived 5 years after surgery. Five-year survival in patients without vascular invasion was 55% (p(001). Tumor invasion of blood and lymph vessels is associated with high probability of tumor dissemination and poor prognosis.

Adenocarcinoma↗
PubMed2001

[Prognostic factors influencing results of the surgical treatment of pancreatic cancer].

In patients with carcinoma of the pancreas 128 gastropancreatoduodenal resections (GPDR), 15 distal resections of the pancreas and 3 pancreatectomies were performed. After GPDR 5-year survival was 12%, the survival median was 24.3 months. Only one patient is living 6 years after left-sided resection and pancreatectomy. Long-term results of the operative treatment for carcinoma of the pancreas depended on the amount of regional metastases, degree of differentiation of the tumor, its size and invasion into the vessels. The long-term results were considerably worse if the tumor was localized in the uncinate process, body and tail of the pancreas. The 5-year survival was noted mainly in patients with the 0 and I stages of the disease. It shows the early diagnostics to be necessary.

Adenocarcinoma↗
PubMed2001

[Some aspects of pathogenesis, clinical manifestations and diagnosis of occupational chronic occupational bronchitis].

The article represents data characterizing course of chronic bronchitis in 78 machinery workers subjected to toxic irritative and sensibilizing aerosols. Findings are early bronchial obstruction and pulmonary emphysema, frequent disorders of microcirculation and lesser circle perfusion, propensity to interstitial pulmonary fibrosis and lung hypertension. The results could serve as a base for pathogenetic therapy and necessitate to include COLD into Occupational Diseases Register.

Adult↗
PubMed1996

[A case of histiocytosis X with extensive changes].

A procedure of epidemiological "case-control" study is presented. The structure and composition of a questionnaire are discussed. The predictive value of 82 +/- 7.3% is considered the basic criterion. The predictive value should be assessed at the stage of planning a study. The paper deals with certain basic characteristics of modern statistical analysis for evaluation of yearly consumption of different foodstuffs and some biochemical components of food.

Adult↗
PubMed1990

[Pulmonary histiocytosis X].

Morphologic studies of the lungs of 61 patients aged 15-62 years with pulmonary histiocytosis X revealed a different morphologic picture in relation to the duration of the disease. The most prevalent were primary and chronic forms characterized by the presence of histiocytic granulomas of varying size with blue-green inclusions, eosinophilia and corpuscles X in the macrophage cytoplasm. As the process progressed, fibrobullous changes occurred in the lungs. An open biopsy of the lungs and testing of the lavage macrophages for corpuscles X appears to be more informative and safe for the morphologic diagnosis of histiocytosis X.

Adolescent↗
PubMed1986

[Morphofunctional status of the lungs in extrinsic allergic alveolitis].

Morphological changes in the lungs of 57 patients suffering from exogenous allergic alveolitis (EAA) are described, the majority of patients had a contact with birds. Interstitial edema, microcirculation disturbances and abundant lymphoid infiltration were observed at an acute initial stage of the disease in 5 patients. Sarcoid-like granulomas in the lung interstitium and bronchiolar wall were found at a subacute stage of the disease in 10 patients along with edema, microcirculatory disturbances and lymphoid infiltration. Predomination of fibrosis with a deformation of all lung structures were observed in 42 patients with a chronic course of the disease.

Adult↗