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Biomedical subjects

I Unsworth

Publications and source records attributed to I Unsworth.

5 recordsLinked to original sources
PubMed1994

Spontaneous Clostridium septicum myonecrosis in congenital neutropaenia.

Spontaneous Clostridium septicum myonecrosis is an uncommon disorder that has been described in association with malignancy, immunosuppression and neutropaenia. Typical clostridial myonecrosis develops without a visible portal of entry and mortality is high. The pathogenesis is not completely understood but the clostridia may gain access to the circulation via areas of ileo-caecal ulceration secondary to enterocolitis, antibiotics or neoplasms. A 5 year old boy with congenital neutropaenia presented with spontaneous Clostridium septicum myonecrosis in the thigh. Limb salvage was achieved using antibiotics, hyberbaric oxygenation and selective debridement. The portal of entry may have been the gastrointestinal tract as colonic ulceration may occur in neutropaenia, and pre-morbid clindamycin administration may have encouraged overgrowth of colonic clostridia.

Anti-Bacterial Agents↗
PubMed1987

Interaction of N-acetylcysteine and bleomycin on hyperbaric oxygen-induced lung damage in mice.

Lung damage in mice exposed to hyperbaric oxygen was assessed by measurement of wet and dry lung weights. The clinically useful thiol compound, N-acetylcysteine (NAC), which is known to maintain tissue levels of reduced glutathione, was found to protect lungs of mice compressed to 445 and 515 kPa oxygen for 30 min. NAC was administered intraperitoneally and the optimal conditions found to be 400 mg/kg 15 min-1 hr before compression. The antineoplastic agent bleomycin, which frequently causes life-threatening lung damage, was administered intratracheally (5 mg/kg), and potentiated lung damage caused by hyperbaric oxygen (445 kPa). NAC effectively protected the lungs of mice exposed to the combined deleterious effect of bleomycin and hyperbaric oxygen.

Acetylcysteine↗
PubMed1985

A double-blind trial of hyperbaric oxygen in the treatment of multiple sclerosis.

A randomized double-blind trial of hyperbaric oxygen (2 atmospheres absolute for 20 sessions of 90 minutes, over a period of one month) demonstrated no advantage over a placebo gas mixture in the treatment of multiple sclerosis. Of 41 patients completing the trial, 21 had been treated with oxygen, eight of whom reported improvement (two confirmed objectively). Of 20 patients in the placebo group, seven claimed improvement (four confirmed objectively). Even when patients with mild disease were considered separately, or when functional systems were assessed individually, no benefit could be shown to result from hyperbaric oxygen therapy.

Adult↗
PubMed1982

Intrauterine bends?

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Abnormalities, Multiple↗