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Biomedical subjects

I Turesson

Publications and source records attributed to I Turesson.

120 records · Page 7Linked to original sources
PubMed1975

Gaucher's disease and benign monoclonal gammapathy. A case report with immunofluorescence study of bone marrow and spleen.

A case of chronic non-neuronopathic Gaucher's disease is presented. The diagnosis was based on the finging of typical Gaucher cells in the bone marrow spleen. The patient also had a benign monoclonal gammapathy. Immunofluorescence studies of bone marrow and spleen were performed using monospecif antisera against immunoglobulin heavy and light chains. The results indicate a monoclonal plasma cell proliferation in the bone marrow, whereas the distribution of plasma cells in the spleen was polyclonal. The combination of chronic Gaucher's disease and monoclonal gammapathy was also found in the patient's brother.

Bone Marrow Cells↗
PubMedDate not supplied

Nucleolar size in benign and malignant plasma cell proliferation;.

Nucleolar and nuclear size of bone marrow plasma cells has been studied in 26 cases of myeloma, 19 of benign essential monoclonal gammapathy (BEMG) and 9 without an M-component. Bone marrow smears were Feulgen-stained to visualize nucleoli and nuclei. Nucleolar area, nuclear area and the ratio nucleolar area/nuclear area were calculated. The myeloma group differed from the other two groups in having plasma cells with larger nucleoli, larger nuclei and an increased ratio nucleolar area/nuclear area. No difference was found between the BEMG group and the cases without an M-component. In some cases--in which the absence of osteolytic lesions at X-ray examination, a low plasma cell percentage in bone marrow smears or a low M-component concentration initially made the diagnosis of myeloma uncertain--the observation of enlarged nucleoli could help to establish the diagnosis. Three cases were observed in which the onset of myeloma was preceded by a long period of essentially unchanged M-component concentration. In these cases a sudden increase of M-component concentration was accompanied by an increase of mean nucleolar size of bone marrow plasma cells.

Bence Jones Protein↗
PubMedDate not supplied

Is occult atrial disorder a frequent cause of non-hemorrhagic stroke? Long-term ECG in 86 patients.

To assess the importance of occult atrial disorder with possible embolization as a cause of non-hemorrhagic stroke, 68 patients with neurologic symptoms lasting 24 hours or more and 18 patients with transient ischemic attacks were examined by long-term electrocardiographic recording (LTER). Lacking matched controls we used a reference population of 103 elderly subjects selected at random from the general population for a previous LTER study. Permanent or episodic atrial arrhythmias of types known to cause cerebral embolization were detected by LTER in 32 (47%) of the 68 patients with a clinical diagnosis of cerebral embolization or thrombosis and in 6 (33%) of the 18 patients with transient ischemic attacks. Of the 38 patients with atrial arrhythmia during LTER 17 had such arrhythmias in their standard ECGs. This frequency of atrial arrhythmias during LTER differs from that of the reference population (p less than 0.025). Thirteen of 16 patients with multiple cerebral lesions had signs of atrial arrhythmia during LTER. Patients having occult atrial disorder with episodic atrial arrhythmia may be an important and common risk group for non-hemorrhagic stroke in addition to the previously recognized group of patients with atrial arrhythmia detectable in the standard ECG. LTER may be important in the evaluation of patients with unexplained stroke.

Aged↗
PubMedDate not supplied

Integration of titanium implants in irradiated bone. Histologic and clinical study.

Nine patients who had undergone combined surgical and radiologic treatment for malignant tumors had skin-penetrating titanium implants inserted in the bone tissue in the treated region at various time intervals after irradiation. The absorbed dose to the implant region varied between 25 and 86 Gy normalized to five fractions of 2.0 Gy/wk, according to the cumulative radiation effect formula. The time interval between irradiation and fixture insertion varied from 9 months to 37 years. Of the 35 fixtures installed, only five were lost because of lack of osseointegration. The follow-up time from implant insertion ranged from 15 to 44 months.

Ear Neoplasms↗
PubMedDate not supplied

Dynamics of irradiation injury to bone tissue. A vital microscopic investigation.

The dynamic changes after a single dose of 15, 25 or 40 Gy 60Co were followed in a titanium vital microscopic bone chamber which permitted observation of the same tissue compartment for over 2 years. The chamber consists of a hollow screw containing 2 glass rods 100 micron apart. The device was inserted into the cortex of the proximal tibial metaphysis of a rabbit. During a healing period of 4 to 6 weeks the space between the glass rods became filled with bone and vessels and in some cases fat. Once a steady state in bone remodelling had been achieved, the animals were irradiated. Vital microscopy was then performed at regular intervals. Mature bone was relatively radioresistant since remodelling continued at a normal rate. In contrast, immature woven bone remained unlamellarized and in some animals tended to increase in amount. The vascular architecture was largely unaltered, even after 40 Gy. Thrombosis or hemorrhage clearly attributable to irradiation was not noted. Initially, the number of fat cells was reduced but repopulation was later seen in several cases.

Adipose Tissue↗
PubMedDate not supplied

Provoked repetitive healing of mature bone tissue following irradiation. A quantitative investigation.

A titanium implant, the bone harvest chamber (BHC), was used to investigate the regenerative capacity of mature bone after irradiation. One BHC was inserted in each proximal tibial metaphysis of a rabbit. One of these implant sites was irradiated (60Co single dose) to either 15 or 25 Gy while the other served as control. Newly formed bone grew through a canal that penetrated the implant. This newly formed bone was harvested from the implant every three weeks following irradiation and then quantified by microradiography and computer-assisted densitometry. In this way a ratio between bone formed on the irradiated side in comparison with the control could be established. An immediate depression in bone formation compared with the non-irradiated controls, was seen at both dose levels. A recovery in bone regenerative capacity was seen at 15 weeks after 15 Gy while the decrease in bone formation remained constant after 25 Gy during the 30 week follow-up period.

Animals↗
PubMedDate not supplied

Bone healing following irradiation during tourniquet ischaemia.

The bone harvest chamber (BHC) methodology, a titanium implant for quantitative evaluations of bone healing, was used in order to investigate the radioprotective function of anoxia, in healing bone tissue. After incorporation of one BHC in each proximal tibial metaphysis of a rabbit it was possible to collect newly formed bone specimens in 3-week-periods without animal sacrifice. The amount of bone was determined by microradiography and densitometry. Ten animals divided into 2 groups were used. One group receiving a single dose of 25 Gy during tourniquet ischaemia was compared with another receiving the same dose during normal blood perfusion. A significantly improved bone healing response was seen in the ischaemic group, with a tendency to further improvement with increasing time after irradiation.

Animals↗
PubMedDate not supplied

A histomorphometric study of bone reactions to titanium implants in irradiated bone and the effect of hyperbaric oxygen treatment.

The present study was undertaken to histomorphometrically analyze early peri-implant bone tissue reactions that occur after radiotherapy and to determine whether hyperbaric oxygen therapy (HBO) affects bone tissue at the microscopic level by altering bone morphology. Twelve rabbits received a single dose (15 Gy) of cobalt60 radiation to one hind leg and the other hind leg served as a control. Titanium screws were placed into the femur and tibia directly after irradiation. Six animals received HBO during the first 4 postoperative weeks. After 8 weeks of follow-up, bone specimens containing the screws were prepared for histomorphometry. Bone-metal contact and the amount of bone in the thread areas and in the mirror areas were measured in a blinded manner. Periosteal bone formation and bone remodeling decreased after irradiation; also after HBO treatment. Hyperbaric oxygen therapy improved bone formation in nonirradiated bone and to some extent also in the irradiated bone. Bone maturation was improved in the HBO animals after irradiation. It was concluded that irradiation reduces the capacity for osseointegration of titanium implants. Hyperbaric oxygen treatment may improve bone formation and especially has positive effects on bone maturation after irradiation.

Animals↗
PubMedDate not supplied

Skin reaction as a biological parameter for prospective studies of different dose schedules with the CRE formula.

The validity of the CRE formula for prospective calculation of biologically equivalent radiation doses with different fractionation schedules has been investigated. Patients with breast cancer were irradiated postoperatively on bilateral parasternal fields. The biological radiation effect was studied by reflectance spectrophotometry of skin erythema and pigmentation. The results from daily irradiation in comparison with twice-a-week, once-a-week, 3-times-a-day and "split-course" irradiation indicate that the formula is a very good predictor of the acute skin erythema and pigmentation.

Breast Neoplasms↗