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Biomedical subjects

I Tsuji

Publications and source records attributed to I Tsuji.

At least 127 records · Page 7Linked to original sources
PubMed1985

Motor time of the rectus femoris under loading of different weights.

Motor time (MT) of the rectus femoris was measured for seven normal subjects during rapid extension of the knee joint at 60 degrees flexion in the sitting position with and without external loads on the leg. MT prolonged linearly with external load from 0 to 4 kg. Tangent of this linearity, the rate of tension development (RTD), was significantly different from one another of the subjects and was not related to MT without external load. RTD is a relevant index to assess an efficiency of rapid force generation of a muscle.

Adult↗
PubMed1985

[Clinical statistics on testicular tumors in the Japanese during the 1970's].

A statistical analysis was made by computer on 511 cases of testicular tumor experienced at 14 facilities in Japan between 1970 and 1979. The age distribution of the patients had two peaks, one under 3 years (15%) and the other between 25 and 34 years (32%). Forty percent of the patients were office workers and 76% were college graduates. Fifty percent of the patients had 0 to 1 sibs. The blood type distribution was similar to that for the whole Japanese population. Six percent of the patients had a past history of trauma, and no relation with cell type was detected. Sixty nine percent of the patients were married and 31% were not married. Sixty seven percent of the patients over 30 had seminoma, and 78% of the patients under 29 years old had non-seminoma. Seminoma was rare in patients under 9 years old. Histologically, 75% were simple type, and 25% were mixed type. Forty three percent of the cases were seminoma and 57% were non-seminoma. Of the stage I cases, 78% and 57%, and of the stage III cases 7 and 28%, respectively, were seminoma and non-seminoma, many of the non-seminoma being at high stage. The 5-year survival rate for the 75 patients under 9 years old was 96%, and that for the 341 patients over 15 years was 70%, the survival rate for the patients under 9 years being significantly higher. The 5-year survival rate for stage I, II and III seminoma was 100, 65 and 0%, respectively, while that for non-seminoma was 93, 56 and 8%, respectively. The survival rate for stage I was higher for seminoma cases than for non-seminoma cases. No difference was detected between survival rate for stage II or III between seminoma and non-seminoma. The survival rate for seminoma did not differ with the time when the surgery was performed, but for the patients with non-seminomatous tumors, the survival rate was higher for the patients operated within one month than those operated later. The survival rate was not related to the weight of the extracted testicle. The 5-year survival rate for the patients with normal body temperature was 78% whereas that for the patients who had fevers was 32%. The 5-year survival rate for the patients not accompanied by abdominal tumors was about 80%, whereas that for the patients with palpated abdominal tumors was 42%.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗
PubMed1984

Wilms tumor and nephrotic syndrome in male pseudohermaphroditism.

A case is reported of a child with male pseudohermaphroditism in whom Wilms tumor developed at age twenty-two months. The tumor was treated accordingly, but the child subsequently died of nephrotic syndrome with renal failure at age thirty-two months. After reviewing the similar concurrence of these disorders described as a syndrome, it was suggested that they may have basic embryologic abnormalities in common and that all of them originate during embryogenesis. The importance of bearing this syndrome in mind in the management of a child with abnormal gonadal differentiation is stressed.

Disorders of Sex Development↗
PubMed1984

Two components of motor time: the tension lag and the tension-developing phase.

Motor time (MT) of the rectus femoris muscle for knee extension under loading on the leg with different weights and latency of isometric tension from the onset of electromyographic activities of the muscle were examined in 7 normal men. MT was linearly related to weights-loaded, indicating that the rate of rapid development of tension was almost linear even in its early phase. MT without a load obtained by calculation using the regression equation and the estimated weight of the leg and foot coincided with latency of isometric tension. It is assumed that MT is composed of two consecutive phases, a tension-lag phase and a rapid tension-developing phase.

Adult↗
PubMed1983

Single ectopic ureter.

We report on 17 female and 4 male patients with single ectopic ureters, 9 of whom also had vaginal ectopic ureters. The clinicopathological features and surgical management are presented, with particular emphasis on the associated renal dysplasia and the complete excision of the ectopic ureteral stump. Although single ureteral ectopia with drainage to the vagina is rare in the English literature the condition is common in Japan.

Adolescent↗
PubMed1982

Prostatic reflux: a simple radiographic sign in recognizing dysfunctioned voiding from external sphincter disorders.

Clinical and urodynamic studies of urethroprostatic reflux were performed in 15 of 40 paraplegics subjected to voiding cystourethrography in the last 5 years. Failure of the external urethral sphincter to relax was confirmed in all patients by either sphincter electromyography or documentation of sympathetic dyssynergia, and high pressure in the prostatic urethra was confirmed by measurement of voiding pressure. A shrewd search for this simple radiographic sign was suggested in the followup of paraplegics because it often served as an early indicator of exposure of the urinary system to the brunt of voiding under high pressure, which presently is believed to be more detrimental to the patients than residual urine. We discuss briefly an anatomical basis for its occurrence preferentially in the peripheral lobe as well as in the central lobe of the prostate in some advanced cases.

Adult↗
PubMed1982

Histopathology of the nonrefluxing megaloureter: a clue to its pathogenesis.

We examined 23 nonrefluxing megaloureters histopathologically. In 18 ureters (group 1) the major anomalies were seen only in the ureterovesical junction, where the condition was characterized by more than well developed muscularity of the ureteral sheaths beside hitherto documented structural anomalies in the intravesical narrowed segment of the ureter. However, the ultrastructure of individual muscle cells was normal in the ureterovesical junction and the dilated portion. In the other 5 ureters (group 2) maldeveloped muscle cells scattered in large amounts of connective tissue were seen in the dilated portion, while in the nondilated narrow segment muscle structure was almost normal by light and electron microscopy. It was conjectured that the pathogenesis of megaloureter in group 2 resides not so much in the ureterovesical junction but more in the dilated ureteral wall, where the lack of actin filaments was documented. In group 1 ureteral sheaths were incriminated to have an additional role in the genesis of ureteral obstruction at the ureterovesical junction.

Actins↗
PubMed1982

Experience with electromyography of the external urethral sphincter in spinal cord injury patients.

Simultaneous recordings of electromyography of the external urethral sphincter and bladder pressure during voiding were done for 71 male patients with spinal cord injury. Discordant activities between the anal and the external urethral sphincters were noted in 39 per cent of the patients. The degree of bladder dysfunction was related more to the degree of dyssynergia of the urethral than the anal sphincter. This detrusor-sphincter dyssynergia was found in 67 per cent of our patients regardless of the differences in cystometric patterns and the level of spinal injury. The importance of electromyography of the external urethral sphincter in the diagnosis of neurogenic bladder dysfunction was stressed. The management of detrusor-sphincter dyssynergia is discussed briefly.

Anal Canal↗
PubMed1982

Relevance of sympathetic dyssynergia in the region of external urethral sphincter: possible mechanism of voiding dysfunction in the absence of (somatic) sphincter dyssynergia.

The genesis of the cystourethrographic appearance of external sphincter spasm in 11 paraplegics with complete lower motor neuron bladders was examined. By the demonstration of its close association with a postural increase in the urethral pressure and catecholamine release, and its responsiveness to alpha-adrenolytic drugs an external sphincter spasm was suggested to be a result of sympathetic dyssynergia in the region of the external sphincter. The smooth muscular component in this region is believed to be a responsible unit of this disorder, since its surgical ablation by means of radical transurethral resection of the prostate uniformly resulted in the relief of sympathetic dyssynergia. The clinical implication of this disorder in the management of vesical dysfunction of the lower motor neuron type is discussed.

Humans↗
PubMed1981

Study of ureteral reflux in neurogenic dysfunction of the bladder: the concept of a neurogenic ureter and the role of the periureteral sheath in the genesis of reflux and supersensitive response to autonomic drugs.

Ureteral pressure and its response to autonomic stimulations were investigated in paraplegics with ureteral reflux and compared to the response in patients with primary reflux, paraplegics without reflux, normal individuals and a patient who had undergone lumbar sympathectomy. Only the paraplegics with ureteral reflux responded supersensitively to the administration of an alpha-adrenergic drug. The demonstration of the specificity of this response to the lower end of the ureter suggested that although it is caused by the changes in the bladder it is dependent on the connection between the bladder and the distal ureter through the periureteral sheath. The ureteral ends in paraplegics with reflux that respond supersensitively to autonomic stimulations were proposed as possibly true cases of a neurogenic ureter in that it is believed to be a consequence of concomitant injury to the ipsilateral parasympathetic motor neuron to the periureteral sheath at the sacral spinal cord level. In the discussion on the mechanism of denervation supersensitivity reference is made to the modern concept of dual neuroanatomy of the ureteral sheath.

Adrenergic alpha-Agonists↗
PubMed1981

Morphological study of the ureterocele: a possible clue to its embryogenesis as evidenced by a locally arrested myogenesis.

The wall of a ureterocele and the proximal ureter involved were investigated with light and electron microscopy. Emphasis in our study was on the muscular structure. In most cases, that is in patients with single or duplex, or simple or ectopic ureteroceles, muscle bundles were hardly developed in the dome of the ureterocele but were well developed in the proximal ureter, with and without dilatation. In the dome of the ureterocele muscle cells were much smaller than those in the proximal ureter. Thick and thin myofilaments were demonstrated in muscle cells in the proximal ureter but thick myofilaments were absent in the dome of the ureterocele. These findings may suggest that a ureterocele is a segmental embryonal arrest of the most distal portion of the ureter.

Humans↗
PubMed1981

Radical transurethral resection of the prostate for neurogenic dysfunction of the bladder in male paraplegics.

We herein report our experience with radical transurethral resection of the prostate in 50 paraplegics refractory to conventional conservative therapy, including the use of alpha-adrenolytic drugs and clean intermittent self-catheterization. The operation was successful in 46 patients (92 per cent) and unsuccessful in 4 tetraplegics with complete high cervical lesions. We discuss the rationales of this procedure for neurogenic dysfunction of the bladder and present urodynamic changes in the successful and unsuccessful cases. This extensive and, yet, microsurgically anatomical resection of the urethral sphincter is recommended for all refractory paraplegics except for complete tetraplegics with high cervical lesions.

Adult↗
PubMed1981

Studies of D-penicillamine (3): immunomodulating effects of D-penicillamine.

D-penicillamine (D-PA) has beneficial therapeutic effects for patients with rheumatoid arthritis but no convincing explanation has been offered for the mode of action. Experiments reported here were designed to gain an insight into the related mechanisms. Wistar rats were inoculated with various doses of Mycobacterium tuberculosis to induce adjuvant arthritis, and on the 21st day, the lesions of paws and ears were graded according to the extent of the erythema and swelling. Rats given D-PA simultaneously with the inoculation of M. tuberculosis developed a more severe arthritis than that seen in the control group, when they were inoculated with low doses of M. tuberculosis. To investigate the effect of D-PA on hemolytic plaque forming cells (PFC) in the spleen, BDF1 mice were immunized with various doses of sheep red blood cells (SRBC) and D-PA was injected in various doses and at various times. D-PA produced either enhancement or depression of the number of PFC, depending on the dose of antigenic stimulus of SRBC. Furthermore, D-PA slightly enhanced the concanavalin A-induced blastogenesis of the spleen cells in vitro, at a concentration of 1-50 microM, but at concentrations of 500 microM, inhibition was evident. These results indicate that D-PA may act as an immunomodulating agent.

Adjuvants, Immunologic↗
PubMed1980

A variant form of arylsulfatase A in human urine derived directly from the renal pelvis: kinetic and immunological characterization.

Arylsulfatase A (aryl-sulfate sulfohydrolase, EC 3.1.6.1) was examined in voided and in nephrostomic urine. A variant form of the enzyme was found in nephrostomic urine, in addition to the minor form, which is the sole component of arylsulfatase A in voided urine. The nephrostomic enzyme differed from the voided urine enzyme with respect to the kinetic parameters, the isoelectric point, heat stability and immunological reactivity. The isoelectric points of the voided urine and nephrostomic enzymes were 4.7 and 5.3, respectively. The nephrostomic enzyme was more heat-labile at 62.5 degrees C than the voided urine enzyme. Although the Km values of the two enzymes with nitrocatechol sulfate as substrate were almost the same, the V value of the nephrostomic enzyme was approx. one-hundredth that of the voided urine enzyme. The molecular weight (almost 130 000) did not differ between the voided urine and nephrostomic enzymes. It was demonstrated by various methods, using IgG antibody against the purified voided urine enzyme, that the nephrostomic enzyme was antigenically distinct from the voided urine enzyme.

Cerebroside-Sulfatase↗
PubMed1980

Arylsulfatase A activity of urine in patients with various genitourinary tract disorders.

Arylsulfatase A activity was measured in urine from patients with various genitourinary tract disorders such as bladder tumor and inflammation. No significant difference in enzyme activity was found between normal and affected urine on the basis of either the volume or protein content of urine, a finding which differed from previous results. However, it was demonstrated that urine from affected patients was more labile to heat treatment in comparison with the control. Upon pretreatment of urine arylsulfatase A at 62.5 degrees C for 10 min, an average of 57% of the original activity was lost in samples from patients with bladder tumor, 58% in those with testicular tumor and 62% in cystitis and urethritis, respectively, while the enzyme activity in the control urine lost only 27% with similar heat treatment. These results were statistically significant with p < 0.001. The arylsulfatase A from patients with advanced bladder tumors demonstrated the presence of a variant form (pI 5.3) which was not detected in normal urine. This variant of arylsulfatase A was also demonstrated in nephrostomy urine from patients with congenital obstruction of the pelvi-ureteric junction.

Adult↗