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Biomedical subjects

I Thompson

Publications and source records attributed to I Thompson.

69 records · Page 4Linked to original sources
PubMed1987

Splenic B cell lymphoma with circulating villous lymphocytes: differential diagnosis of B cell leukaemias with large spleens.

The clinical, haematological, morphological and histological features of a series of 22 patients presenting with splenic lymphoma with circulating villous lymphocytes were assessed and compared with those of patients with other forms of chronic B cell leukaemia in an attempt to differentiate this condition from hairy cell leukaemia, prolymphocytic leukaemia, and chronic lymphocytic leukaemia, with which this condition has many features in common. The disease was twice as common in men than in women, with a mean (SD) age at diagnosis of 72 (9) years, and the most consistent presenting feature was massive enlargement of the spleen, which showed white and red pulp disease with a plasmacytic component. Small monoclonal bands were found in 60% of cases.

B-Lymphocytes↗
PubMed1987

[Comparative study of neurolinguistic variables in Alzheimer patients, traumatic aphasias and Korsakoff psychoses and normal control probands].

There are few studies of the breakdown of language in specific dementias and there is some dispute that language pathology in brain failure is comparable to that of focal lesions. It is recognized that while aphasic language is a disturbance of receptive and propositional speech, disturbances of "InnerLanguage" disrupt the planning and regulatory basis of behavior. This paper presents a comparison of three pathological groups to match normal controls and suggest that in its initial stages reduced cognitive performances in Alzheimers type Dementia and Korsakow Psychosis on non verbal measures maybe a further of the regulatory role of inner speech comparison with traumatic Aphasia which more clearly exists on a deficit of verbal comprehension and expression.

Alcohol Amnestic Disorder↗
PubMed1985

Expression of surface antigens recognized by the monoclonal antibody lan 3-2 during embryonic development in the leech.

The monoclonal antibody lan 3-2 was used as a marker for the developmental expression of surface antigens which are specific for the two pairs of nociceptive neurons and a subset of axons in the adult CNS of the leech. In Haemopis embryos labeling of both nerve fibers and cell bodies with the antibody appears as expected for a metameric animal in a rostrocaudal temporal gradient from about day 5-6. Surprisingly, all central cell bodies are stained by the antibody in early development. However, later in embryogenesis around day 17 the staining intensity of most cells decreases except for the nociceptive cells, which remain antibody-positive, and the adult staining pattern gradually emerges. In addition to describing the central staining pattern, we show that specific peripheral neurons associated with the segmental sensilla also are antibody-positive during development. The distribution and developmental expression of the lan 3-2-positive antigens are compared between two phylogenetically different species of leeches and the diversity of the staining pattern of the monoclonal antibody is discussed.

Animals↗
PubMed1983

Surface molecules identify groups of growing axons.

Studies on vertebrate and invertebrate species have established that, during development, axons have the ability to choose particular paths over others. The chemical basis of this pathfinding is not clear but biochemical differences between neurons have long been postulated to account for the specificity of neuronal connections. Such subtle molecular differences between different cells in a single tissue are difficult to study with standard biochemical techniques but hybridoma technology has offered a potential solution to this type of problem. This technique has made possible the production of monoclonal antibodies for identifying and characterizing a family of glycoproteins which are expressed on the surface of specific axon bundles during the development of the leech nervous system. The results show that groups of growing axons do indeed carry chemically distinct surface molecules.

Animals↗
PubMed1982

Reversal of persistent anovulation in polycystic ovarian disease by administration of chronic low-dose follicle-stimulating hormone.

Low doses of follicle-stimulating hormone (FSH) were administered once daily to two consecutive patients with polycystic ovarian disease (PCOD) for therapy of infertility. Serial blood samples were obtained for gonadotropins and ovarian steroid determinations during the period of FSH administration. Exogenous FSH resulted in an initial and concomitant decrease in serum androstenedione (A), estrone (E1), and luteinizing hormone (LH), with an increase in estradiol (E2) and FSH. Subsequent changes in the above-mentioned hormonal levels were typical of a normal ovulatory cycle, with the exception of FSH, which continued to rise in the second half of the follicular phase. This was attributed to the exogenous administration of FSH. Both patients became pregnant in their first induced ovulatory cycle by administration of chronic low-dose FSH. These preliminary data demonstrate (1) a correction of the biochemical imbalance characteristic of PCOD, (2) successful ovulation induction, and (3) restoration of fertility in PCOD treated with chronic low-dose FSH.

Adult↗
PubMed1980

Retinal ganglion cell projections to the superior colliculus of the hamster demonstrated by the horseradish peroxidase technique.

After a localized injection of horseradish peroxidase into the superior colliculus of the golden hamster, retinal cells of all sizes, except the very smallest, were labeled. Since the smallest cells were probably glia or interneurons, these results indicate that in the hamster all retinal ganglion cell types project directly to the contralateral superior colliculus. This finding is in agreement with recent physiological studies dealing with the conduction velocities of retinocollicular axons in the hamster.

Animals↗
PubMed1977

Ultrasound as a new method of male contraception.

Twenty male cats were treated once or twice with 1 watt/sq cm of ultrasound for 10 minutes. Each of 24 male dogs received one to three treatments with 1 watt/sq cm for 10 minutes. Another six dogs were treated with 2 watts/sq cm for 15 minutes. Four Cebus apella monkeys were treated with the same dosage as that used for the cats and dogs. A dosage of 1 watt/sq cm for 10 minutes was also applied to four human patients without the use of anesthetics, and no pain or side effects were noted. In all treated animals as well as in human patients the results indicate that ultrasound significantly suppresses spermatogenesis according to the dosage and frequency of treatment, without any effect on Leydig cells or blood testosterone levels.

Animals↗
PubMed1975

Oral immunisation and its significance in the prophylactic control of enteritis in the preruminant calf.

Oral immunisation using a feed-incorporated vaccine comprising heat inactivated Escherichia coli and Salmonellae antigens was examined in feeding trials with calves. The studies were conducted with batches of calves purchased at intervals throughout one year and reared in an environment created by continuous occupancy. Improved health was registered in terms of a significant reduction in the incidence and duration of diarrhoea (P less than 0.01) and in the need for treatment with medicament or antibiotics (P less than 0.01). Orally immunised calves showed a significantly better weight gain (1.44 kg, P less than 0.05) than the controls during the period 0 to 5 weeks. This gain was mainly obtained during the first three weeks when the antigen fed calves showed significantly improved faeces scores and a significantly better appetite for concentrates (P less than 0.05).

Administration, Oral↗
PubMedDate not supplied

Woldenberg Village: an illustration of supportive design for older adults.

Woldenberg Village, an aging-in-place residential facility, is the result of 2 years of research and development. The design solution integrates physical, social, psychological, medical, and operational requirements to provide an opportunity for a gracious, dignified life-style as an individual ages. Each component of the village is designed to provide, in an unobtrusive way, differing amounts of support to meet the different needs of each individual. Design features include a barrier-free environment; a choice of paths and routes from one location to another; single-story construction; and clustered, user-friendly apartments. The primary goal of these features is to promote independence and safety for the elderly. Additional goals include accommodating the individual's changing needs; allowing the individual to remain in the apartment of his or her choice as long as possible through physical design and the promotion of physical assistance; and reducing medical and social problems through physical design and promotion of mutual assistance.

Aged↗