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Biomedical subjects

I Tagaya

Publications and source records attributed to I Tagaya.

At least 55 records · Page 3Linked to original sources
PubMed1973

Induction of skin resistance to vaccinia virus in rabbits by vaccinia-soluble early antigens.

The immunological role of vaccinia-soluble early antigen was examined in rabbits. The antigens were prepared from HeLa cells infected with a conditional lethal mutant of vaccinia virus, which induces in these cells early antigens including those responsible for surface immunofluorescence of infected cells, but not viral DNA and late protein syntheses. Immunization of rabbits with the antigens in Freund's complete adjuvant induced complement-fixing antibody but neither detectable circulating neutralizing antibody nor any detectable level of inhibitory substance or interferon in the skin of the animals. When immunized animals were inoculated intradermally with vaccinia virus, multiplication of virus in the skin was greatly inhibited, being accompanied by an earlier appearance as well as an accelerated wane of the local reactions. The resistance could not be transferred passively by the serum of immunized animals to normal rabbits. Immunization of rabbits with the antigens without the adjuvant not only failed to inhibit but, contrariwise, enhanced the multiplication of intradermally inoculated vaccinia virus, inducing heavy skin lesions and exalted virus multiplication.

Animals↗
PubMed1973

Characterization of poliovirus isolates in Japan after the mass vaccination with live oral poliomyelitis vaccine (Sabin).

From 1962 to 1968, 127 poliovirus isolates (92 from clinical specimens and 35 from healthy subjects) were subjected to intratypic serodifferentiation by the modified Wecker and McBride techniques. The two techniques gave concordant results for 103 strains, 91 of which were classified as vaccine-like, 9 as nonvaccine-like, and 3 as intermediate; 20 were classified as vaccine-like by one technique and as intermediate by the other, and 4 as nonvaccine-like by one technique and as intermediate by the other. The origin of the nonvaccine-like strains is unknown, but it is unlikely that they had been circulating in the community long. An rct/40-marker test of the isolates revealed a higher positivity rate than that found in field trials of Sabin vaccine. The results indicate that wild poliovirus has been almost completely eradicated from Japan.

Humans↗
PubMed1973

Poliomyelitis in Japan during the period 1962-68 after the introduction of mass vaccination with Sabin vaccine.

After the mass vaccination of children of susceptible age groups in Japan in 1961, the incidence of poliomyelitis decreased markedly. From 1962 to 1968 a total of 659 paralytic cases were officially notified. Detailed investigations of 626 cases reported to the Poliomyelitis Surveillance Committee revealed that only 185 (29.6%) were cases of paralysis clinically typical of poliomyelitis. Tests on 120 of these 185 cases showed that 75 (62.5%) were positive for poliovirus: 45 of these positive cases were temporally associated with the administration of live poliovirus vaccine and 36 had some residual disability. Wild types of poliovirus were rarely isolated. Only 36 vaccine-related cases of poliomyelitis were observed among the total of more than 11 million newborn infants vaccinated with Sabin vaccine in the period 1962-68.

Adolescent↗
PubMed1972

Outbreaks of monkeypox and serological surveys in nonhuman primates.

In connexion with the recent detection of cases of monkeypox in man in West and Central Africa, the frequency of monkeypox outbreaks in monkeys since 1958, when the disease was first recognized in captive animals, has been investigated. Special incidence surveys were made for this purpose. During the last 3 years, a serological survey has been conducted to find natural foci of monkeypox virus, and a total of 2 242 sera from monkeys of different species from various parts of Africa and Asia have been examined for poxvirus antibodies. The survey failed to detect any significant indication of poxvirus infections. The observations suggest that although a few human cases of monkeypox have been identified, monkeypox in the natural environment is not widespread and is perhaps localized in small areas.

Africa↗
PubMed1971

Sero-epidemiological survey on Yaba and 1211 virus infections among several species of monkeys.

The distribution of neutralizing antibody to Yaba virus and 1211 agent in the sera of three Asian and one African monkey species was examined.Cynomolgus (Macaca irus), bonnet (M. radiata) and rhesus (M. mulatta) monkeys possessed antibody to Yaba virus at incidences of 19.9, 8.4 and 0%, respectively. In African green monkeys (Cercopithecus aethiops) the incidence was as high as 76.4%.As for 1211 agent, no Asian monkeys had neutralizing antibody and 5.5% of African green monkey sera neutralized the virus.

Animals↗