Biomedical subjects
Publications and source records attributed to I T Weterman.
A study of the HLA-A, -B, -C, and -DR antigens in patients with Crohn's disease and controls did not reveal a significant strong association with a particular HLA antigens. A segregation analysis of parental HLA haplotypes in nine families with at least two children suffering from Crohn's disease did not show a significant deviation from the expected Mendelian segregation.
A group of 310 unrelated patients suffering from Crohn's disease has been screened for quantitative and electrophoretic variations of alpha 1-antitrypsin (alpha 1AT). A comparison was made betweeen patients and healthy controls. The distribution of electrophoretic alpha 1AT variants in the patients showed no significant deviation from the controls. The alpha 1AT quantities are significantly higher in the Crohn's disease population than in the controls.
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In a series of 226 patients with Crohn's disease admitted to the University Hospital at Leiden between 1934 and 1972, 21 of the 60 patients with almost total colonic involvement were treated by an ileo-rectal anastomosis between 1957 and 1973. Sixteen patients underwent a proctocolectomy between 1948 and 1972. Five of them have previously had an ileo-rectal anastomosis and are therefore included in both groups. The patients have been followed up for a mean period of 8.3 years. There was no surgical mortality in the group of ileo-rectal anastomosis, whereas in the group of proctocolectomy there have been one early and one late postoperative death. The recurrence rate after ileo-rectal anastomosis was 75 per cent, but 40 per cent of these cases responded well to conservative treatment and have not required further surgery. The recurrence rate after proctocolectomy was 31 per cent. The results concerning mortality, morbidity, and recurrence are compared with the series in the literature.