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Biomedical subjects

I T Knysh

Publications and source records attributed to I T Knysh.

At least 19 recordsLinked to original sources

[Functional characteristics of the endocrine glands in skin melanoma patients].

TI-2NOMO skin melanoma patients revealed pronounced functional disturbances of the pineal gland and pituitary-adrenal system. The decline in functional activity of the former was manifested by a decrease in urine excretion of melatonin. Enhanced levels of blood ACTH, alpha-MSH and cortisole pointed to the activation of pituitary-adrenal system which was particularly high in males. The degree of endocrine disorders was found to be in correlation with tumor stage. As far as pathogenesis of the lesion is concerned, preparations which bring function of endocrine glands to normal should be adjuvant to available treatment modalities for melanoma.

Adrenal Cortex↗

[Treatment results in chordomas of the saccrococcygeal area].

The influence of various factors on the survival of 40 patients with sacral chordoma is considered. Irrespective of type of therapy, the 5-year survival after treatment of malignant chordoma was 31.5 +/- 14.6%, while in cases of benign chordoma it was 73.9 +/- 10.0%. The 10 year survival rates were 31.5 +/- 14.6 and 34.2 +/- 10.8%, respectively. The 5-year survival rates increased 3-fold after ablastic removal of tumor and by 37.9% after combination therapy (surgery + radiation). The age and sex differences had no significant prognostic value. Radical ablastic removal of sacral chordoma is of great prognostic value since it ensures favorable prognosis, irrespective of morphological type of tumor.

Adolescent↗