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Biomedical subjects

I Szeri

Publications and source records attributed to I Szeri.

At least 55 records · Page 3Linked to original sources
PubMed1976

Decreased cellular immune response of germ-free mice.

Cellular immune response to intracerebral lymphocytic choriomeningitis infection was studied in mice belonging to an identical strain but different in breeding conditions. In consequence of the cellular immune reaction on the leptomeninx, lymphocytic choriomeningitis developed and caused death in 100% of conventionally bred mice, whereas 80% of germ-free and 15% of mouse-pathogen-free mice failed to display lymphocytic infiltration of the leptomeninx and survived the infection as chronic virus carriers. This finding pointed to a deficient cellular immune response of germ-free and mouse-pathogen-free mice. The under-development of the lymphoid system due to the antigen-poor breeding conditions might be responsible for the deficiency.

Animals↗
PubMed1976

Studies on the lymphoid system of mice with lethal acute toxoplasmosis.

Acute toxoplasmosis was induced in CFLP mice by infecting them intraperitoneally with the 25 x 10(3) multiplicity of the virulent RH strain of Toxoplasma gondii. The lymphoid system of mice succumbing to acute toxoplasmosis showed characteristic changes. Significant spleen hypertrophy (spleen index: 1.76), severe thymus atrophy (thymus index: 0.27) and a striking decrease of the lymphocyte count in blood (86%) was found as compared with the uninfected controls.

Acute Disease↗
PubMed1975

Bone changes in young mice with impaired lymphoid system.

Disturbances of osseal growth were observed in young mice with their lymphoid system affected by antihymocyte serum or mitolactol (dibromodulcitol) treatment. These bone changes were similar to those observed in germ-free and neonatally thymectomized mice as well as in mice suffering from a graft vs. host reaction. Their severity was in direct correlation with the disturbance of the thymus dependent lymphoid system. Not only immunological adaptation but also normal bone growth appears to require an intact thymus and thymus dependent lymphoid system.

Animals↗
PubMed1975

Course of lymphocytic choriomeningitis virus infection in young and aged mice.

The course and histological picture of intracerebral LCM virus infection was found to differ in mice with their thymus displaying an age-dependent involution and in young adult animals. Signs of lymphocytic choriomeningitis were absent in 75 per cent of the aged animals. The change of the characteristic clinical and histological picture referred to the decreased cellular immune response of aged animals, ascribed to the age-dependent involution of the thymus.

Age Factors↗
PubMed1975

Combined phytohaemagglutinin and dianhydrodulcitol treatment of lymphocytic choriomeningitis virus infection in mice.

The course of intracerebral lymphocytic choriomeningitis (LCM) virus infection was studied in mice treated simultaneously with dianhydrodulcitol (DAD) and phytohaemagglutinin (PHA). Earlier experiments revealed that DAD decreased and PHA enhanced the cellular immune response of mice to LCM virus infection. On applying the treatments simultaneously they inhibited each other and neither the decreasing effect of DAD nor the enhancing effect of PHA on the cellular immune response could be observed.

Animals↗
PubMed1975

Significance of lymphoid atrophy in the pathogenesis of wasting syndrome.

Mice with their lymphoid system made atrophic by neonatal thymectomy, showed increased sensitivity to DAD a lymphotropic cytostatic agent. Wasting syndrome developed earlier and in a higher per cent of neonatally thymectomized mice, when the animals were treated also with the subethal dose of DAD.

Animals↗
PubMed1975

Effect of lymphotropic cytostatic agent in newborn and suckling mice.

The sensitivity of newborn and suckling mice to a lymphotropic cytostatic agent (DAD) was found to be increased as compared to adult mice. Results indicated that a single dose of DAD being ineffective in adult mice, caused irreversible impairment in the lymphoid system of newborn and suckling mice with underdeveloped lymphoid system. This led to the development of lethal wasting resembling the wasting syndrome. On the basis of its consequences the DAD treatment, applied in newborn age, may be considered as "cytostatic thymectomy".

Aging↗
PubMed1975

Study on the interaction of lymphotropic cytostatic agent treatment and graft-versus-host (GVH) reaction in mice.

F1 hybrid mice (C57BL X C3H) suffering from graft-versus-host disease, were treated with dianhydrodulcit (DAD) a lymphotrop cytostatic agent. 15 mg/kg of the compound was injected intraperitoneally, 8 days following the administration of the parental spleen cell suspension. The interaction between the two interventions is discussed on the basis of the rate and time course of deaths observed is the individual groups, as well as on the state of the lymphoid organs of the succumbed and sacrificed animals.

Animals↗