Biomedical subjects

I Székely

Publications and source records attributed to I Székely.

12 recordsLinked to original sources

PubMed1999

The laparoscopic technique for bilateral inguinal hernias.

From March 1994 to March 1999 359 laparoscopic hernioplasties have been performed on 295 patients. In 349 cases (97.2%) TAPP (transabdominal preperitoneal), in 10 cases (2.8%) TEP (total extraperitoneal) method was used for the treatment. In 64 cases (21.7%) bilateral hernias were operated using TAPP-method only. There were 15 hidden hernias and 14 recurrences on the contralateral side in this group. The hernial ring was covered with two smaller meshes or one bigger. There were no intraoperative complications. In 21 cases (32.8%) subcutaneous emphysema and in 3 cases (4.6%) sero-haematoma was developed. The emphysemas were solved spontaneously in 2-3 hours after the surgery. One haematoma was needed punction. The patients were discharged from the hospital on the second or third postoperative day. The authors found that the bilateral laparoscopic hernioplasty much more favourable for the patients.

Adolescent↗

PubMed1997

[Endoscopic ligation of bleeding esophageal varices].

Endoscopic variceal ligation (EVL) is a new method for treating oesophageal varices, which was developed to reduce the high complication rate seen with endoscopic sclerotherapy. This technique consists of mechanical occlusion and thrombosis applying small elastic bands around the variceal channels in the distal oesophagus. We report 39 patients treated with EVL during the period from April 1995 to December 1996. The average age of patients was 50.1 years, 33 men, 6 women. Portal hypertension was caused by alcoholic liver disease in 36 patients. Seven patients died within 1 month. Varices were eradicated in 28 patients. Variceal eradication required an average of 3, 4 sessions. Active bleeding was controlled by EVL in 11 patients out of 12. Recurrent bleeding occurred in 14 out of 39 patients (35%). One oesophageal perforation occurred in connection with overtube placement. There were no other major complications. In conclusion EVL is an effective treatment for bleeding oesophageal varices.

Endoscopy↗

PubMed1995

[Proctitis caused by Chlamydia trachomatis].

The authors report a case of a 32-year-old patient who has been treated for idiopathic proctitis for 10 years. The inflammation did not react to Salazopyrin and corticosteroid therapy. Significant stenosis has developed. The probability of Chlamydia infection has emerged because of the atypical morphological appearance and therapy resistance of the process. The Chlamydia infection was verified by serological examinations and direct immunofluorescent detection of the pathogen taken from biopsy specimen. The proctitis has been cured by Doxycyclin and roxithromycin therapy. The authors call attention to the different diagnostic significance of the disease considering that strictures requiring surgical operation can develop in cases being unrecognised and treated inadequately. The case is the first report of the disease in Hungary.

Adult↗

PubMed1984

Structure-activity relationship (SAR) among prostacyclin (PGI2) analogues.

The main aims of the research for new PGI2 analogues are to increase (1) the duration of action and/or (2) biological selectivity. To meet requirement (1), the structure of PGI2 had to be stabilized chemically and biologically. To achieve chemical stabilization an electron-withdrawing group (e.g. oxo-, phenyl) was inserted adjacent to the enol-ether unit into the PGI2 molecule. Such compounds as 7-oxo-PGI2, 4-oxo-PGI2, m-interphenylene-2,3,4-trinor-PGI2 are stable to hydrolysis although they possess a somewhat diminished biological activity as measured by the antiaggregatory activity and in vivo hypotensive action. There was no significant change in the selectivity between the two kinds of activities. "Biological stabilization" was attempted by elaborating the series of m-interphenylene-PGI2-s with modification of the PG-skeleton. Compounds such as m-interphenylene-2,3,4-trinor-13,14-didehidro-20-methy l-PGI2 is considered to be "fully stabilized". There was a gain in selectivity, however the increase in the duration of action was not significant. However, even PGI2 has certain activities of the "hit and run" type revealed mainly in the cytoprotective effect at different organs. Such an example, the delayed antiischaemic effects of PGI2 and 7-oxo-PGI2 in dogs are discussed.

Animals↗

PubMed1984

Interrelationships between the chemical structure of prostanoids and prostacyclins and their cytoprotective effects on the ethanol-induced gastric mucosal damage in rats (a comparative experimental study).

Structurally modified prostaglandins have been synthesized, PGF2 alpha skeleton being substituted at the 13 and 17 position. The prostacyclin analogues were modified at the 3,13 or 17 positions of the prostacyclin skeleton. The effect of these compounds was studied on the development of gastric mucosal damage produced by the intragastric administration of 96% ethanol. The different compounds were given intraperitoneally 30 min before the administration of ethanol. The number and severity of gastric mucosal lesions (ulcers) were recorded without and with the use of different compounds. The prostanoids and prostacyclin analogues were given in doses of 1, 5, 25 or 126 micrograms/kg. Among the tested compounds several fairly active molecules could be found. The significance and practical usefulness of these modifications of prostaglandins and prostacyclins are discussed with special respect to the stereochemistry of molecules.

Animals↗

PubMed1982