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Biomedical subjects

I Suzuki

Publications and source records attributed to I Suzuki.

At least 307 records · Page 17Linked to original sources
PubMed1985

In vivo activity of cefbuperazone (T-1982) against various experimental infections in mice.

The protective activity of cefbuperazone (T-1982) was compared with those of latamoxef, cefotaxime, and cefmetazole against intraperitoneal and urinary tract infections in mice. In both tests, cefbuperazone manifested a higher activity than the other cephems against infections with Escherichia coli and Klebsiella pneumoniae. Cefbuperazone also showed a comparatively high degree of prophylactic effect; this activity was observed even when given 4 hours before bacterial challenge. The good in vivo activity of cefbuperazone could not be explained by the differences between the antibiotics on the basis of the serum levels and vitro activity. Mice, treated with cefbuperazone, showed a statistically significant prolongation of survival time against intraperitoneal challenge with Candida albicans, but not when treated with the other cephems. This finding suggests that the host defense mechanisms stimulated by cefbuperazone may contribute to the good in vivo activity of this antibiotic.

Animals↗
PubMed1985

[Transfer of latamoxef into human burn blister fluid and its pharmacokinetic analysis].

Latamoxef (LMOX) (50 mg/kg) was administrated intravenously to burned patients over 1 hour period. Burn blister fluid and serum were taken during 8 hours after injection, and concentrations of LMOX in burn blister fluid and serum were determined by bioassay using E. coli as a test organism. The serum concentrations of LMOX were 170.8 +/- 30.6 micrograms/ml at 30 minutes, 227.0 +/- 19.8 micrograms/ml at 1 hour, 90.3 +/- 21.4 micrograms/ml at 2 hours, 52.9 +/- 14.6 micrograms/ml at 3 hours, 38.7 +/- 13.3 micrograms/ml at 4 hours, 25.1 +/- 8.1 micrograms/ml at 5 hours, 20.5 +/- 8.1 micrograms/ml at 6 hours, 13.0 +/- 5.5 micrograms/ml (mean +/- S.D., n = 5) at 8 hours after the injection. The LMOX concentrations in burn blister fluid were 36.9 +/- 32.8 micrograms/ml at 30 minutes, 77.5 +/- 42.2 micrograms/ml at 1 hour, 85.4 +/- 19.6 micrograms/ml at 2 hours, 76.4 +/- 18.5 micrograms/ml at 3 hours, 63.5 +/- 17.8 micrograms/ml at 4 hours, 54.9 +/- 17.1 micrograms/ml at 5 hours, 34.8 +/- 10.3 micrograms/ml at 6 hours, 25.2 +/- 4.8 micrograms/ml (mean +/- S.D., n = 7) at 8 hours after the injection. The data obtained were analysed pharmacokinetically. The serum levels were analysed by two-compartment model, and the LMOX levels in burn blister fluid were analysed by the model, in which blister was considered as a small part of the peripheral compartment. In results, Tmax and Cmax of LMOX levels in burn blister fluid were calculated as 1.81 hours and 90.6 micrograms/ml, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1984

Directional sensitivity of neurons in the lumbar spinal cord to neck rotation.

A combination of roll and pitch stimuli was applied to the head of decerebrate, labyrinthectomized cats to determine the direction of maximal sensitivity ('vector') of lumbar neurons to neck rotation. Some neurons were best modulated by pitch, others by roll or by intermediate stimulus planes. Among modulated neurons were propriospinal neurons activated antidromically from the lumbosacral enlargement.

Animals↗
PubMed1984

Lectins modulate prostaglandin E2 production by rat peritoneal macrophages.

The effect of Aloctin A (Alo A), a lectin having anti-inflammatory activities, on prostaglandin (PG) E2 production by activated rat peritoneal macrophages was compared with that of concanavalin A (Con A), wheat germ agglutinin (WGA), plsum sativum agglutinin (PSA) and soybean agglutinin (SBA). Alo A, WGA, Con A and PSA at 10 micrograms per ml inhibited PG E2 production. But SBA, even at a dose of 1 microgram per ml, stimulated PG E2 production. The inhibition by Alo A treatment of the release of radioactivity from (3H)arachidonic acid-labeled macrophages and the stimulation of this release by SBA treatment were observed. The uptake of (51Cr)-labeled sheep red blood cells by the macrophage was inhibited by Alo A, Con A, and PSA, all at 10 micrograms per ml and SBA at 1 microgram per ml, however, WGA at 10 micrograms per ml stimulated the uptake of the sheep red blood cells. The mechanism of the anti-inflammatory properties of Alo A was discussed.

Animals↗
PubMed1984

Intracranial recording of short latency somatosensory evoked potentials in man: identification of origin of each component.

In normal subjects the short latency SEPs generally consisted of 3 positive waves (P9, P11, P14) and a succeeding negative wave (N20). To determine the origins of these waves we have made intracranial records from 17 patients, which suggest the following results. P9 originates in stimulated median nerve peripheral to the dorsal roots such as brachial plexus, P11 in the dorsal column of the cervical cord, P14 in the cuneate nucleus and medial lemniscal pathway, and N20 in the cerebral cortex. On the basis of intracranial and intraspinal records, the onset of P11 indicates the arrival of the afferent volley at the cord entry and the peak latency of P11 its arrival time at the C1-2 level dorsal column. The onset latency of P14 indicates the onset of postsynaptic events in cuneate nucleus neurons and the peak latency of P14 arrival at the midbrain. From the ventral surface of the brain-stem 3 positive waves (P'9, P'11, P'14) like the initial positive components of the scalp short latency SEPs (P9, P11, P14) were recorded. The amplitude of P'14 was large compared to that of P14. The peak latencies of P'14 recorded at the medulla and the pons were shorter than that of P14 by 0.7-0.8 msec and 0.2-0.5 msec, respectively. The peak latency of P'14 at the midbrain was almost the same as that of P14. By measuring the distance between the recording electrodes in the brain-stem and the peak latency difference of P'14, the fastest lemniscal conduction velocity was estimated as 56 m/sec.

Adult↗
PubMed1984

Hemopexin levels in mice.

Using a simple measurement system of hemopexin, single radial immunodiffusion-plate, the following results were obtained; firstly the normal level of hemopexin concentration in mouse was 0.55-1.25 mg ml-1. Secondly, antitumor agents were classified into two types on the basis of changes of hemopexin levels after administration of the agents. Finally, a positive statistical correlation between solid type tumor weight and hemopexin concentration in the mouse was observed.

Animals↗
PubMed1984

Augmentation of natural cell-mediated cytotoxic reactivity of mouse lymphoid cells by aloctin A.

The levels of natural cell-mediated cytotoxicity could be augmented by administration of Aloctin A (Alo A), a lectin having anti-tumor activity. i.v. administration of Alo A induced augmentation of cytotoxicity by spleen cells and by peritoneal exudate cells (PEC). On the other hand, i.p. administration of Alo A induced augmentation of cytotoxicity by PEC but not by spleen cells. The effector cells seemed to be natural killer cells.

Animals↗