Search PubMed⌕ Search

Biomedical subjects

I Stoian

Publications and source records attributed to I Stoian.

27 records · Page 2Linked to original sources
PubMedDate not supplied

Studies regarding the efficiency of Supro isolated soy protein in Olympic athletes.

66 Romanian olympic endurance athletes (30 kayak-canöe, 36 rowing; 45 males and 21 females) participated in our trial, for the purpose to make evident possible biological effects of Supro isolated soy protein supply (1.5 g/kg/day, 8 weeks). At random the athletes were divided into two groups: A group (n = 38) and B group (n = 28). Daily programme (4-6 hours daily, endurance and strength), food and medication were similar for all athletes. The athletes of the A group received daily 1.5 g/kg SuproR soy protein, for 8 weeks while the athletes of the B group did not received soy protein supply. Two months soy protein supply induced increases of body mass (about 3 kg, especially by lean body mass), strength indexes, serum proteins, haemoglobin and total calcium and significant decreases of urinary mucoproteins and fatigue after training sessions, especially when comparing to the athletes of the B group. No damages of liver, kidney and metabolism tests were noticed in all athletes; no side effects were noticed and the product was well tolerated by athletes. When applying the cross-over method for other 2 months we obtained the same results. Based on these data the authors support the idea of a beneficial effect of this soy protein supply on the biological preparation of endurance top athletes.

Adult↗
PubMedDate not supplied

[Production and characterization of some mouse embryo cellular substrates in vitro].

Cell cultures with a different multiplication potential in vitro, depending upon the strain source used, were obtained from mouse embryos belonging to the CVA, C57 Black A2G and Swiss strains. Only the Swiss 12 culture underwent spontaneous transformation and was carried through more than 50 passages in vitro. The Swiss-12 substrate proved not to be contaminated either by viruses or micoplasma. It is less sensitive than other elective cell substrates to infection with attenuated polioviruses, cytopathogenic Coxsackie A9 virus and vaccinia virus, but its sensitivity to infection with Herpes simplex type 1 virus is similar to that of human embryo fibroblasts. After a high number of passages the Swiss-12 substrate permits, in comparison to other cell substrates (human heteroploid Hep-2 line, human embryo fibroblasts), a highly efficient qualitative differentiation between the growth media and calf serum.

Animals↗
PubMedDate not supplied

[Arrhythmias in patients with mitral valve prolapse].

The object of the present investigation was the discovery of the arrhythmias in the patients with prolapse of the mitral valve (PMV), the types of arrhythmias, the factors favouring them, the therapy used. In a group of 126 patients suffering from PMV, 25 had mitral insufficiency, and 48% of the cases had arrhythmias too. The ventricular arrhythmias existed in 18 patients, in the most of them as ventricular extrasystoles. Only in 2 cases, ventricular paroxysmal tachycardia was noticed, and only one case of ventricular fibrillation was recorded. The following conclusions were drawn from the study: the increase of arrhythmias is low, their appearance is correlated with mitral insufficiency, ventricular arrhythmias are predominant, the majority are benign, they are more frequent than in the patients with neurovegetative dystonia (if considering the prolapse associated with systolic murmur), necessity of periodic control for discovering the cases with high risk of ventricular arrhythmias with malignant potential.

Adolescent↗
PubMedDate not supplied

Assessment of hypertension levels control and management (hypertension "AUDIT" project). Study in a population of workers.

The hypertension AUDIT project (WHO) was used for the study of large populations of workers in two Romanian industrial centers, Slatina and Sibiu, constituted into two main groups. The objects of the study were: the detection of new cases of arterial hypertension (AH) and of their proportion as compared with older cases, the assessment of the quality of diagnosis control and treatment methodology as well as the estimation of the patient's attitude regarding the conditions of treatment and of the physician's knowledge and attitude regarding AH. Group I (Slatina) included 22,839 workers and the program was applied in 15,740 randomly chosen subjects. Group II (Sibiu) included 14,874 workers of whom 2,838 were randomly chosen for study. From a total of 606 (6.20%) subjects aged 35 to 64 years with AH in both groups, 494 (81.51%) were older cases and 112 (18.48%) were newly detected. The prevalence of AH was found to increase with age and to be higher in women aged 55 to 64 years. The treatment in older cases from both groups was considered effective in 232 cases (46.96%) (of which 26 (11.2%) with overtreatment) and insufficient in 262 (53%). The reasons alleged by the patients for the late detection of AH were the absence of symptoms and a casual interest for their state of health. The risk factors were systematically checked. Smoking was found in 30.36% of the subjects in group I and in 31% of those in group II. The use of diagnostic laboratory procedures was corresponding to the present recommendations. The nonpharmaceutic therapy was frequently recommended, especially reduction of salt consumption. Besides that, pharmaceutic treatment was indicated in most of the patients (63% in group I and 90% in group II). Diuretics (41.26% in group I and 75% in group II), and beta blocking drugs (35.3% in group I and 70% in group II) were the most frequently administered and in a lesser proportion vasodilators with central or peripheral action, calcium blockers, Rauwolfia and angiotensin conversion enzyme inhibitors. The consumer inquiry showed satisfactory compliance of patients, most of them took their tablets regularly, were satisfied with the medical assistance and preferred to consult the same physician. The data of the physician inquiry regarding diagnosis treatment of AH and professional training also proved satisfactory. The use of the AUDIT project has allowed a complex estimation of AH in the groups studied and will prove useful for a more efficient control of AH in the whole population.

Adolescent↗
PubMedDate not supplied

Apoptosis, I: General considerations.

This review tried to offer a basis for properly integrating genetic, biochemical, and cellular indicators of apoptosis in order to facilitate a better understanding of the control and mechanisms of apoptosis.

Animals↗