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Biomedical subjects

I Steiner

Publications and source records attributed to I Steiner.

At least 127 records · Page 7Linked to original sources
PubMed1989

Intraventricular interferon treatment for subacute sclerosing panencephalitis.

Three children with subacute sclerosing panencephalitis (SSPE) were treated with alpha-interferon. Medication was administered via an Ommaya reservoir into the cerebral ventricular system over a period of 13 to 24 months in increasing amounts up to 1.0 x 10(6) IU twice weekly. Mild clinical improvement in two children and a stable course in the third were associated with improvement of electroencephalographic recordings in all patients and a decrease in antimeasles antibodies in the cerebrospinal fluid of two. The small number of patients does not enable us to determine whether this course was the natural history of SSPE in our patients or whether it was induced by treatment, yet it seems that intraventricular interferon treatment can modify the course of SSPE.

Child↗
PubMed1989

[Arrhythmogenic dysplasia of the right ventricle].

The authors describe a case of sudden death of a 22-year-old man where on necropsy arrhythmogenic dysplasia of the right ventricle was found. The authors describe the clinical and morphological picture of this recent nosological unit. They discuss its relationship with Uhl's anomaly. Attention is drawn to concurrent affection of the left ventricle.

Adult↗
PubMed1989

[Comparison of the degree of chronic gastritis in the resected gastric body with histologic findings in postoperative gastric biopsy].

In resected portions of the stomach we find chronic atrophic gastritis of the corpus only in 10% of the patients with duodenal ulcers, and chronic inflammatory changes are, contrary to patients with a gastric ulcer, less marked. The difference is statistically significant. Consistent with some other authors, we find that great progression of chronic inflammatory changes occurs in patients operated on account of duodenal ulcers in the course of the first three years after operation. From six cases of regression of chronic inflammatory changes after operation, in two cases undetected atrophic gastritis was involved which was present in a severe form in the body of the resected portion beyond the vicinity of the gastric ulcer. According to the author's findings regression of atrophic gastritis is possible. The high score of chronic inflammatory changes in the antrum of gastric resectates (3.54) and in the close vicinity of gastric ulcers (4.0) confirms the frequency of severe antral gastritis in peptic ulceration and the intensity of the focal inflammation in the vicinity of gastric ulcers.

Adult↗
PubMed1989

[Cardiomyopathy of the right ventricle].

Right ventricular cardiomyopathy (arrhythmogenic right ventricular dysplasia) is a recently described entity characterized morphologically either by an absence of the right ventricular myocardium (Uhl's anomaly; parchment heart), or by replacement of the myocardium by adipose tissue (lipomatous cardiomyopathy). Three cases of the disease are presented. The simultaneous involvement of the left ventricle is stressed.

Adult↗
PubMed1988

Fulminant subacute sclerosing panencephalitis in association with pregnancy.

Subacute sclerosing panencephalitis developed during pregnancy in a 27-year-old woman and immediately after delivery in an 18-year-old woman. In both, disease took an acute and fulminant course culminating in a vegetative state within several weeks. It is suggested that the relative older age of disease presentation and the unusually rapid neurologic deterioration were partially due to immunologic and hormonal alterations of pregnancy.

Adolescent↗
PubMed1988

Sensory peripheral neuropathy of vitamin B12 deficiency: a primary demyelinating disease?

In five patients with peripheral neuropathy due to vitamin B12 deficiency, electrodiagnostic studies demonstrated severe reduction in sensory nerve conduction velocities compatible with a demyelinating disorder affecting sensory nerve fibres. It is suggested that in some patients lack of vitamin B12 may cause primary sensory demyelinating neuropathy.

Adolescent↗
PubMed1988

Chronic progressive myelopathy: its relation to the spinal progressive form of multiple sclerosis.

The causes and clinical features of chronic progressive myelopathy (CPM) were evaluated in a retrospective study of 107 patients. A special emphasis was put on those in whom no underlying cause for the myelopathy could be determined. Of 76 such, 39 (51%) had oligoclonal immunoglobulins (Ig) in the CSF and were therefore considered as possible MS, while the remainder, without oligoclonal Ig, were designated "myelopathy of unknown origin" (MUO). Our "possible MS" group was similar clinically to reported series of proven spinal MS, and it seems therefore, that the presence of oligoclonal Ig permits the recognition of a group of patients with myelopathy who might be at a greater risk for MS. Patients with MUO differed from possible MS patients in several clinical characteristics, but most significantly in disease course and levels of functional disability which were more benign in the former. Myelopathy in possible MS patients was also of a primary pyramidal and asymmetrical nature. It is therefore suggested that the segregation of patients with CPM of undetermined origin into 2 separate groups based on the presence or absence of oligoclonal Ig might be of prognostic significance.

Adult↗
PubMed1988

Latent herpes simplex virus type 1 transcription in human trigeminal ganglia.

We studied latent herpes simplex virus type 1 gene expression in human trigeminal ganglia. Two transcripts were mapped to a 3.0-kilobase region within the long repeat region and appeared to be located in neuronal nuclei. These viral RNAs were not abundant during lytic replication and may represent an alternative pattern of herpes simplex virus type 1 gene expression involved in the pathogenesis of latent infection.

Adult↗
PubMed1988

Antibiotic therapy for infected Ommaya reservoir systems.

The major complication of prolonged use of a permanently implanted Ommaya reservoir system is bacterial infection, encountered in 3 to 15% of patients. The best therapeutic approach to ventriculitis and meningitis occurring in the presence of this device is still a subject of debate. We reviewed our experience in 66 consecutive patients receiving intraventricular therapy via the Ommaya reservoir for leptomeningeal metastases or for subacute sclerosing panencephalitis. Eight episodes of infection occurred during the period of treatment, and all of them responded to systemic antibiotics with or without intraventricular treatment. Removal of the Ommaya reservoir was avoided, and therapy via the device for the underlying disease was resumed as soon as the infection was controlled. No relapse of infection occurred during a minimal follow-up of 40 days. On the basis of our experience and review of the literature, we challenge the concept that the Ommaya device, as a foreign body, must be removed to treat such infections successfully.

Adolescent↗